Anne R. Gooding
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View article: RNA-induced PRC2 inhibition depends on the sequence of bound RNA
RNA-induced PRC2 inhibition depends on the sequence of bound RNA Open
Methyltransferase PRC2 (Polycomb Repressive Complex 2) deposits histone H3K27 trimethylation to establish and maintain epigenetic gene silencing. PRC2 is precisely regulated by accessory proteins, histone post-translational modifications, …
View article: RNA-induced PRC2 inhibition depends on the sequence of bound RNA
RNA-induced PRC2 inhibition depends on the sequence of bound RNA Open
SUMMARY Methyltransferase PRC2 (Polycomb Repressive Complex 2) deposits histone H3K27 trimethylation to establish and maintain epigenetic gene silencing. PRC2 is precisely regulated by accessory proteins, histone post-translational modific…
View article: Structural basis for inactivation of PRC2 by G-quadruplex RNA
Structural basis for inactivation of PRC2 by G-quadruplex RNA Open
Polycomb repressive complex 2 (PRC2) silences genes through trimethylation of histone H3K27. PRC2 associates with numerous precursor messenger RNAs (pre-mRNAs) and long noncoding RNAs (lncRNAs) with a binding preference for G-quadruplex RN…
View article: Evaluation of the RNA-dependence of PRC2 binding to chromatin in human pluripotent stem cells
Evaluation of the RNA-dependence of PRC2 binding to chromatin in human pluripotent stem cells Open
Polycomb Repressive Complex 2 (PRC2), an important histone modifier and epigenetic repressor, has been known to interact with RNA for almost two decades. In our previous publication (Long, Hwang et al. 2020), we presented data supporting t…
View article: PRC2 direct transfer from G-quadruplex RNA to dsDNA has implications for RNA-binding chromatin modifiers
PRC2 direct transfer from G-quadruplex RNA to dsDNA has implications for RNA-binding chromatin modifiers Open
The chromatin-modifying enzyme, Polycomb Repressive Complex 2 (PRC2), deposits the H3K27me3 epigenetic mark to negatively regulate expression at numerous target genes, and this activity has been implicated in embryonic development, cell di…
View article: Structural basis for inactivation of PRC2 by G-quadruplex RNA
Structural basis for inactivation of PRC2 by G-quadruplex RNA Open
The histone methyltransferase PRC2 (Polycomb Repressive Complex 2) silences genes via successively attaching three methyl groups to lysine 27 of histone H3. PRC2 associates with numerous pre-mRNA and lncRNA transcripts with a binding prefe…
View article: DNMT1 inhibition by pUG-fold quadruplex RNA
DNMT1 inhibition by pUG-fold quadruplex RNA Open
Aberrant DNA methylation is one of the earliest hallmarks of cancer. DNMT1 is responsible for methylating newly replicated DNA, but the precise regulation of DNMT1 to ensure faithful DNA methylation remains poorly understood. A link betwee…
View article: DNMT1 inhibition by pUG-fold quadruplex RNA
DNMT1 inhibition by pUG-fold quadruplex RNA Open
Aberrant DNA methylation is one of the earliest hallmarks of cancer. DNMT1 is responsible for methylating newly replicated DNA, but the precise regulation of DNMT1 to ensure faithful DNA methylation remains poorly understood. A link betwee…
Bending and looping of long DNA by Polycomb repressive complex 2 revealed by AFM imaging in liquid Open
Polycomb repressive complex 2 (PRC2) is a histone methyltransferase that methylates histone H3 at Lysine 27. PRC2 is critical for epigenetic gene silencing, cellular differentiation and the formation of facultative heterochromatin. It can …
Regulation of histone methylation by automethylation of PRC2 Open
Polycomb-repressive complex 2 (PRC2) is a histone methyltransferase that is critical for regulating transcriptional repression in mammals. Its catalytic subunit, EZH2, is responsible for the trimethylation of H3K27 and also undergoes autom…
Regulation of histone methylation by automethylation of PRC2 Open
Polycomb Repressive Complex 2 (PRC2) is a histone methyltransferase whose function is critical for regulating transcriptional repression in many eukaryotes including humans. Its catalytic moiety EZH2 is responsible for the tri-methylation …
View article: Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2
Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2 Open
Polycomb repressive complex 2 (PRC2) is a key chromatin modifier responsible for methylation of lysine 27 in histone H3. PRC2 has been shown to interact with thousands of RNA species in vivo, but understanding the physiological function of…
View article: Author response: Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2
Author response: Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2 Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Polycomb repressive complex 2 (PRC2) is a key chromatin modi…