Anne Gulbech Ording
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View article: Anti‐thrombotic therapy in patients with cancer at the end of life: A cohort study using population‐linked routinely collected data
Anti‐thrombotic therapy in patients with cancer at the end of life: A cohort study using population‐linked routinely collected data Open
Summary Anti‐thrombotic therapy (ATT) in cancer patients approaching the end of life presents significant clinical challenges, balancing thrombotic and bleeding risks. This study analysed ATT prescribing patterns and associated outcomes in…
View article: Determining Drug Exposure Based on Medication Dispensing Data: A Validation Study of Vitamin K Antagonist Treatment Episodes Against <scp>INR</scp> Records
Determining Drug Exposure Based on Medication Dispensing Data: A Validation Study of Vitamin K Antagonist Treatment Episodes Against <span>INR</span> Records Open
Background In pharmaco‐epidemiological studies using vitamin K antagonist (VKA) exposure, constructing treatment episodes based on dispensed prescriptions is challenging, particularly due to the large variability in therapeutic dose. Objec…
View article: Quality of vitamin K antagonist treatment during the last year of life
Quality of vitamin K antagonist treatment during the last year of life Open
Limited data exist on the quality of anticoagulation in patients approaching the end of life. This study evaluated vitamin K antagonist (VKA) anticoagulation control during the last year of life, using nationwide data from Statistics Nethe…
View article: Discontinuation of Anticoagulants and Occurrence of Bleeding and Thromboembolic Events in Vitamin K Antagonist Users with a Life-limiting Disease
Discontinuation of Anticoagulants and Occurrence of Bleeding and Thromboembolic Events in Vitamin K Antagonist Users with a Life-limiting Disease Open
Data on risks and benefits of long-term anticoagulants in patients with a life-limiting disease are limited. This cohort study aims to describe (dis)continuation of anticoagulants and incidences of bleeding and thromboembolic events in vit…
View article: Quality indicators and development targets in the national clinical quality registries in cancer care and screening
Quality indicators and development targets in the national clinical quality registries in cancer care and screening Open
Background The Danish clinical quality registries monitor and improve the quality of care, using quality indicators and defined development targets referred to as ‘standards’. This study aims to investigate the fulfilment of standards in t…
View article: Involving patients and the public in cancer associated thrombosis research: A strategy for success
Involving patients and the public in cancer associated thrombosis research: A strategy for success Open
The role of public involvement (PI) in biomedical research has never been greater, with accumulating evidence demonstrating its ability to improve the quality of research and the likelihood of translating findings into clinical practice. A…
View article: Updating the critical steps of the quality implementation framework: a protocol for an umbrella review of reviews
Updating the critical steps of the quality implementation framework: a protocol for an umbrella review of reviews Open
Introduction Implementation science focuses on improving the dissemination, uptake and adoption of evidence into practice. Over the last decade, implementation science research has proliferated, particularly in healthcare and social scienc…
View article: Use of antithrombotic therapy and the risk of cardiovascular outcomes and bleeding in cancer patients at the end of life: a Danish nationwide cohort study
Use of antithrombotic therapy and the risk of cardiovascular outcomes and bleeding in cancer patients at the end of life: a Danish nationwide cohort study Open
Despite uncertain benefit-risk profile, most terminally ill cancer patients continue ATT until the end of life. These findings provide insights into current ATT utilization and discontinuation dynamics in the challenging context of termina…
View article: The (dis)continuing of antithrombotic drugs and its implications for occurrence of adverse cardiovascular and bleeding events in cancer patients during end of life
The (dis)continuing of antithrombotic drugs and its implications for occurrence of adverse cardiovascular and bleeding events in cancer patients during end of life Open
Background and ObjectivesFor patients receiving end-of-life care, adjusting polypharmacy and deprescription of potentially harmful medicines are important impactors on quality-of-life. Antithrombotic therapies (ATT) are used by 30-50% of p…
View article: In-hospital thromboprophylaxis variation and the risk of venous thromboembolism after lung cancer surgery: a nationwide cohort study
In-hospital thromboprophylaxis variation and the risk of venous thromboembolism after lung cancer surgery: a nationwide cohort study Open
OBJECTIVES Venous thromboembolic event (VTE) is a severe complication in patients with lung cancer undergoing thoracic surgery. Nevertheless, because of insufficient evidence, there are no clear guidelines, and VTE prophylaxis practices va…
View article: Risk of Venous Thromboembolism in Patients With Stage III and IV Non–Small-Cell Lung Cancer: Nationwide Descriptive Cohort Study
Risk of Venous Thromboembolism in Patients With Stage III and IV Non–Small-Cell Lung Cancer: Nationwide Descriptive Cohort Study Open
VTE risks vary substantially according to cancer treatments and cancer stages. The highest risk was observed in the initial 6 months of therapy initiation. These insights emphasize the need for tailored risk assessment and vigilance in man…
View article: Associations between pregnancy-related factors and birth characteristics with risk of rare uterine cancer subtypes: a Nordic population-based case–control study
Associations between pregnancy-related factors and birth characteristics with risk of rare uterine cancer subtypes: a Nordic population-based case–control study Open
View article: Direct oral anticoagulation versus warfarin in atrial fibrillation: a nationwide cohort study of effectiveness and safety among frail patients
Direct oral anticoagulation versus warfarin in atrial fibrillation: a nationwide cohort study of effectiveness and safety among frail patients Open
Background Frail patients with atrial fibrillation carry a high risk of both stroke and treatment-related bleeding complications, but evidence for the safety and effectiveness of anticoagulation regimens in frail patients remain sparse. Ob…
View article: Oral anticoagulation among frail patients with atrial fibrillation: assessment of net clinical benefit in a nationwide cohort
Oral anticoagulation among frail patients with atrial fibrillation: assessment of net clinical benefit in a nationwide cohort Open
Background Frail patients with atrial fibrillation (AF) are often undertreated with oral anticoagulants (OAC), and evidence for the net clinical benefit of OAC is sparse. Objectives We examined the risk of thromboembolic events and major b…
View article: Cancer risk in the siblings of individuals with major birth defects: a large Nordic population-based case-control study
Cancer risk in the siblings of individuals with major birth defects: a large Nordic population-based case-control study Open
Background Individuals with major birth defects are at increased risk of developing cancer, indicating a common aetiology. However, whether the siblings of individuals with birth defects are also at an increased risk of cancer is unclear. …
View article: Risk of recurrent cancer-associated venous thromboembolism: A Danish nationwide cohort study
Risk of recurrent cancer-associated venous thromboembolism: A Danish nationwide cohort study Open
Six-month recurrence risk after first-time cancer-associated venous thromboembolism was high and varied by cancer type and patient characteristics. Refining risk stratification for recurrence may improve decision-making regarding treatment…
View article: Towards optimal use of antithrombotic therapy of people with cancer at the end of life: A research protocol for the development and implementation of the SERENITY shared decision support tool
Towards optimal use of antithrombotic therapy of people with cancer at the end of life: A research protocol for the development and implementation of the SERENITY shared decision support tool Open
We aim to develop an intervention that guides the appropriate use of antithrombotic therapy, prevents bleeding complications, and saves healthcare costs. Hopefully, usage of the tool leads to enhanced empowerment and improved quality of li…
View article: Long-Term Management of Pulmonary Embolism: A Review of Consequences, Treatment, and Rehabilitation
Long-Term Management of Pulmonary Embolism: A Review of Consequences, Treatment, and Rehabilitation Open
The concept of pulmonary embolism is evolving. Recent and emerging evidence on the treatment of specific patient populations, its secondary prevention, long-term complications, and the unmet need for rehabilitation has the potential to cha…
View article: Sex differences in childhood cancer risk among children with major birth defects: a Nordic population-based nested case-control study
Sex differences in childhood cancer risk among children with major birth defects: a Nordic population-based nested case-control study Open
Background Childhood cancer is more common among children with birth defects, suggesting a common aetiology. Whether this association differs by sex is unclear. Methods We performed a population-based nested case-control study using nation…
View article: The Khorana score and venous and arterial thrombosis in patients with cancer treated with immune checkpoint inhibitors: A Danish cohort study
The Khorana score and venous and arterial thrombosis in patients with cancer treated with immune checkpoint inhibitors: A Danish cohort study Open
View article: Oral anti‐coagulant treatment patterns in atrial fibrillation patients diagnosed with cancer: A Danish nationwide cohort study
Oral anti‐coagulant treatment patterns in atrial fibrillation patients diagnosed with cancer: A Danish nationwide cohort study Open
Data on the use of oral anti‐coagulants (OAC) for stroke prevention in cancer patients with atrial fibrillation (AF) are sparse. Nationwide cohort study of patients with AF (2012–2018) and an indication for OAC who were diagnosed with canc…
View article: Validation of the Khorana score for predicting venous thromboembolism in 40 218 patients with cancer initiating chemotherapy
Validation of the Khorana score for predicting venous thromboembolism in 40 218 patients with cancer initiating chemotherapy Open
The Khorana score is recommended for guiding primary venous thromboembolism (VTE) prophylaxis in cancer patients, but its clinical utility overall and across cancer types remains debatable. Also, some previous validation studies have ignor…
View article: Hematuria in anticoagulated patients with atrial fibrillation and urologic cancer
Hematuria in anticoagulated patients with atrial fibrillation and urologic cancer Open
View article: Bleeding complications in patients with gastrointestinal cancer and atrial fibrillation treated with oral anticoagulants
Bleeding complications in patients with gastrointestinal cancer and atrial fibrillation treated with oral anticoagulants Open
Background Direct oral anticoagulants (DOACs) may increase the risk of gastrointestinal (GI) bleeding in patients with atrial fibrillation (AF) and GI cancer compared with vitamin K antagonists (VKA). Methods We conducted a Danish nationwi…
View article: Increasing Incidence and Declining Mortality After Cancer-Associated Venous Thromboembolism: A Nationwide Cohort Study
Increasing Incidence and Declining Mortality After Cancer-Associated Venous Thromboembolism: A Nationwide Cohort Study Open
View article: Plasma Vitamin B12 Levels, High-Dose Vitamin B12 Treatment, and Risk of Dementia
Plasma Vitamin B12 Levels, High-Dose Vitamin B12 Treatment, and Risk of Dementia Open
Background: It is controversial whether B12 deficiency causes dementia or B12 treatment can prevent dementia. Objective: To assess associations between low plasma (P-)B12 levels, B12 treatment, and risk of Alzheimer’s disease (AD; primary …
View article: Cancer risk in individuals with major birth defects: large Nordic population based case-control study among children, adolescents, and adults
Cancer risk in individuals with major birth defects: large Nordic population based case-control study among children, adolescents, and adults Open
Objective To examine associations between birth defects and cancer from birth into adulthood. Design Population based nested case-control study. Setting Nationwide health registries in Denmark, Finland, Norway, and Sweden. Participants 62 …
View article: Long-term mortality in young and middle-aged adults hospitalised with chronic disease: a Danish cohort study
Long-term mortality in young and middle-aged adults hospitalised with chronic disease: a Danish cohort study Open
Objectives To examine the long-term outcomes for patients hospitalised with chronic diseases at age 30, 40 or 50 years. Design Nationwide, population-based cohort study. Setting All Danish hospitals, 1979–1989, with follow-up through 2014.…
View article: Metastasis directed treatment of brain metastases from colorectal cancer – a Danish population-based cohort study
Metastasis directed treatment of brain metastases from colorectal cancer – a Danish population-based cohort study Open
Background: Brain metastases (BMs) are an uncommon presentation of metastatic colorectal cancer (mCRC) with reported incidence of about 2-4%. Today, there is an increased awareness towards a metastasis directed treatment approach wi…
View article: Cancer and risk of Alzheimer's disease: Small association in a nationwide cohort study
Cancer and risk of Alzheimer's disease: Small association in a nationwide cohort study Open
Introduction Small observational studies with short‐term follow‐up suggest that cancer patients are at reduced risk of Alzheimer's disease (AD) compared to the general population. Methods A nationwide cohort study using Danish population‐b…