Anne Horne
YOU?
Author Swipe
View article: Antifracture Efficacy of 5- or 10-Yearly Zoledronate in Women Aged 50 to 60 Years: Secondary Analyses of a Randomized Trial
Antifracture Efficacy of 5- or 10-Yearly Zoledronate in Women Aged 50 to 60 Years: Secondary Analyses of a Randomized Trial Open
Context We recently reported that zoledronate (zol) given once at baseline or twice (every 5 years) reduced fracture risk over 10 years. Objective We assessed whether the effects of zol differ over time or across important baseline variabl…
View article: Perceptions About Asymptomatic Hyperuricemia and Views About Urate‐Lowering Therapy in People With Asymptomatic Hyperuricemia
Perceptions About Asymptomatic Hyperuricemia and Views About Urate‐Lowering Therapy in People With Asymptomatic Hyperuricemia Open
Objective Asymptomatic hyperuricemia is a precursor of gout and is also associated with cardiovascular disease and chronic kidney disease. The aim of this study was to understand perceptions about asymptomatic hyperuricemia and views about…
View article: Intraoperative Care and Complications of Symptomatic Adolescent and Young Adult Patients Undergoing Laparoscopy to Diagnose and/or to Treat Endometrioses: A Multi-Institutional Review
Intraoperative Care and Complications of Symptomatic Adolescent and Young Adult Patients Undergoing Laparoscopy to Diagnose and/or to Treat Endometrioses: A Multi-Institutional Review Open
We demonstrate that laparoscopy for diagnosis and/or treatment of endometriosis has low complication and reoperation rates in adolescent and young adult patients. Performing concurrent indicated procedures, particularly LNG-IUS placement, …
View article: The Influence of Patient Factors on the Population Pharmacokinetics of Colchicine: Implications for Safe and Effective Dosing
The Influence of Patient Factors on the Population Pharmacokinetics of Colchicine: Implications for Safe and Effective Dosing Open
View article: POS1231 COLCHICINE CONCENTRATIONS AND RELATIONSHIP WITH COLCHICINE EFFICACY AND ADVERSE EVENTS; POST-HOC ANALYSIS OF A RANDOMISED CLINICAL TRIAL OF COLCHICINE FOR GOUT FLARE PROPHYLAXIS
POS1231 COLCHICINE CONCENTRATIONS AND RELATIONSHIP WITH COLCHICINE EFFICACY AND ADVERSE EVENTS; POST-HOC ANALYSIS OF A RANDOMISED CLINICAL TRIAL OF COLCHICINE FOR GOUT FLARE PROPHYLAXIS Open
View article: Colchicine Concentrations and Relationship With Colchicine Efficacy and Adverse Events: Post Hoc Analysis of a Randomized Clinical Trial of Colchicine for Gout Flare Prophylaxis
Colchicine Concentrations and Relationship With Colchicine Efficacy and Adverse Events: Post Hoc Analysis of a Randomized Clinical Trial of Colchicine for Gout Flare Prophylaxis Open
Objective Our objective was to examine the relationship between colchicine plasma concentrations and clinical and demographic factors and to determine the relationship between colchicine concentrations and colchicine efficacy and colchicin…
View article: Bisphosphonates Trigger Anti-Ageing Effects Across Multiple Cell Types and Protect Against Senescence
Bisphosphonates Trigger Anti-Ageing Effects Across Multiple Cell Types and Protect Against Senescence Open
Bisphosphonates (BPs) have been the major class of medicines used to treat disorders of excessive bone loss for over five decades. Recently it has been recognized that BPs may also have additional significant beneficial extra-skeletal effe…
View article: Development of gout in people with asymptomatic hyperuricemia: study protocol for a 5-year prospective cohort
Development of gout in people with asymptomatic hyperuricemia: study protocol for a 5-year prospective cohort Open
Introduction The central biochemical cause of gout is hyperuricemia (elevated serum urate levels). Ultrasound features of monosodium urate (MSU) crystal deposition are common in people with asymptomatic hyperuricemia. However, it is unclea…
View article: Comparison of a handheld ultrasound device with cart-based ultrasound for the assessment of gout lesions in people with established gout
Comparison of a handheld ultrasound device with cart-based ultrasound for the assessment of gout lesions in people with established gout Open
Handheld ultrasound can detect gout lesions in people with established gout. However, concordance between cart-based and handheld ultrasound in detection of some gout lesions is low, particularly double contour and aggregates.
View article: Baseline Dual‐Energy Computed Tomography Urate Volume Predicts Fulfillment of Gout Remission After Two Years of Urate‐Lowering Therapy
Baseline Dual‐Energy Computed Tomography Urate Volume Predicts Fulfillment of Gout Remission After Two Years of Urate‐Lowering Therapy Open
Objective This study aimed to identify variables that predict gout remission in people with erosive gout receiving urate‐lowering therapy. Methods We analyzed data from a two‐year, double‐masked randomized‐controlled trial of people with e…
View article: The development and evaluation of dose‐prediction tools for allopurinol therapy (Easy‐Allo tools)
The development and evaluation of dose‐prediction tools for allopurinol therapy (Easy‐Allo tools) Open
Aims Dose escalation at the initiation of allopurinol therapy can be protracted and resource intensive. Tools to predict the allopurinol doses required to achieve target serum urate concentrations would facilitate the implementation of mor…
View article: Randomised trial of genetic testing and targeted intervention to prevent the development and progression of Paget’s disease of bone
Randomised trial of genetic testing and targeted intervention to prevent the development and progression of Paget’s disease of bone Open
View article: The statistical challenge of analysing changes in dual energy computed tomography (DECT) urate volumes in people with gout
The statistical challenge of analysing changes in dual energy computed tomography (DECT) urate volumes in people with gout Open
Normalising highly skewed DECT urate volume data is challenging. Adopting commonly used transformation techniques may not significantly improve the ability to determine differences in measures of central tendency when comparing the change …
View article: No Effect of NSAID Use on Efficacy of Zoledronate: A Post Hoc Analysis of a Randomized Trial in Osteopenic Older Women
No Effect of NSAID Use on Efficacy of Zoledronate: A Post Hoc Analysis of a Randomized Trial in Osteopenic Older Women Open
Bisphosphonates are widely used for the prevention and treatment of osteoporosis. Nonsteroidal anti-inflammatory drugs (NSAIDs) are also widely used among the older population group at high risk of fractures. NSAIDs have been shown to impa…
View article: The Patient Experience of Gout Remission: A Qualitative Study
The Patient Experience of Gout Remission: A Qualitative Study Open
Objective Preliminary remission criteria for gout have been developed. However, the patient experience of gout remission has not been described. This qualitative study aimed to understand the patient experience of gout remission and views …
View article: Effect of oral zoledronate administration on bone turnover in older women
Effect of oral zoledronate administration on bone turnover in older women Open
Aim The aim of this work is to assess the safety and efficacy of two oral zoledronate preparations by determining their effects on bone resorption in healthy postmenopausal women. Methods The preparations studied were zoledronic acid in en…
View article: Effects of elevated serum urate on cardiometabolic and kidney function markers in a randomised clinical trial of inosine supplementation
Effects of elevated serum urate on cardiometabolic and kidney function markers in a randomised clinical trial of inosine supplementation Open
In observational studies, serum urate positively associates with cardiometabolic and kidney diseases. We analyzed data from a randomised placebo-controlled trial to determine whether moderate hyperuricemia induced by inosine affects cardio…
View article: Development of a radiographic scoring system for new bone formation in gout
Development of a radiographic scoring system for new bone formation in gout Open
View article: Development of a radiographic scoring system for new bone formation in gout
Development of a radiographic scoring system for new bone formation in gout Open
Background Features of new bone formation (NBF) are common in tophaceous gout. The aim of this project was to develop a plain radiographic scoring system for NBF in gout. Methods Informed by a literature review, scoring systems were tested…
View article: What Represents Treatment Efficacy in Long-term Studies of Gout Flare Prevention? An Interview Study of People With Gout
What Represents Treatment Efficacy in Long-term Studies of Gout Flare Prevention? An Interview Study of People With Gout Open
Objective The patient experience of gout flares is multidimensional, with several contributing factors including pain intensity, duration, and frequency. There is currently no consistent method for reporting gout flare burden in long-term …
View article: Author response for "Bone mineral density and bone turnover ten years after a single 5mg dose or two 5‐yearly lower doses of zoledronate in osteopenic older women: an open‐label extension of a randomized controlled trial"
Author response for "Bone mineral density and bone turnover ten years after a single 5mg dose or two 5‐yearly lower doses of zoledronate in osteopenic older women: an open‐label extension of a randomized controlled trial" Open
View article: Elevated Urate Levels Do Not Alter Bone Turnover Markers: Randomized Controlled Trial of Inosine Supplementation in Postmenopausal Women
Elevated Urate Levels Do Not Alter Bone Turnover Markers: Randomized Controlled Trial of Inosine Supplementation in Postmenopausal Women Open
Objective Observational studies have consistently demonstrated that serum urate level positively correlates with bone mineral density (BMD). We undertook this study to determine whether moderate hyperuricemia induced by inosine supplements…
View article: Molecular characterisation of osteoblasts from bone obtained from people of Polynesian and European ancestry undergoing joint replacement surgery
Molecular characterisation of osteoblasts from bone obtained from people of Polynesian and European ancestry undergoing joint replacement surgery Open
View article: Additional file 1 of Development of a radiographic scoring system for new bone formation in gout
Additional file 1 of Development of a radiographic scoring system for new bone formation in gout Open
Additional file 1: Figure S1. PRISMA flow diagram for literature review. Table S1. Frequency of the most commonly used scoring systems that assess any feature of new bone formation (n = 840 papers)a. Data are presented for the most frequen…
View article: Bone Mineral Density and Bone Turnover 10 Years After a Single 5 mg Dose or Two 5-Yearly Lower Doses of Zoledronate in Osteopenic Older Women: An Open-Label Extension of a Randomized Controlled Trial
Bone Mineral Density and Bone Turnover 10 Years After a Single 5 mg Dose or Two 5-Yearly Lower Doses of Zoledronate in Osteopenic Older Women: An Open-Label Extension of a Randomized Controlled Trial Open
Intravenous zoledronate reduces fracture risk (5 mg at 18-month intervals) and prevents bone loss (doses of 1 to 5 mg for 3 to >5 years), but the duration of action of a single 5 mg dose and the effects of lower doses beyond 5 years are…
View article: Effect of a Three-Day Course of Dexamethasone on Acute Phase Response Following Treatment With Zoledronate: A Randomized Controlled Trial
Effect of a Three-Day Course of Dexamethasone on Acute Phase Response Following Treatment With Zoledronate: A Randomized Controlled Trial Open
Zoledronate is a potent intravenous bisphosphonate effective in the management of osteoporosis, Paget's disease and skeletal-related events in malignancy. Its most frequent adverse effect is the acute phase response (APR), an inflammatory …
View article: Effect of body mass index on serum urate and renal uric acid handling responses to an oral inosine load: experimental intervention study in healthy volunteers
Effect of body mass index on serum urate and renal uric acid handling responses to an oral inosine load: experimental intervention study in healthy volunteers Open
Background High body mass index (BMI) is strongly associated with hyperuricaemia. It is unknown whether overweight and obesity influences serum urate primarily through increased urate production or reduced renal clearance of uric acid. The…
View article: Gout Flare Severity From the Patient Perspective: A Qualitative Interview Study
Gout Flare Severity From the Patient Perspective: A Qualitative Interview Study Open
Objective The patient experience of a gout flare is multidimensional. To establish the most appropriate methods of flare measurement, there is a need to understand the complete experience of a flare. This qualitative study aimed to examine…
View article: Predictors of Fracture in Older Women With Osteopenic Hip Bone Mineral Density Treated With Zoledronate
Predictors of Fracture in Older Women With Osteopenic Hip Bone Mineral Density Treated With Zoledronate Open
A recent analysis has found that during treatment with denosumab, women attaining higher bone densities (BMD) are less likely to have incident fractures. We have reexamined this important question using data from our recent trial of zoledr…
View article: The effect of age on the microarchitecture and profile of gene expression in femoral head and neck bone from patients with osteoarthritis
The effect of age on the microarchitecture and profile of gene expression in femoral head and neck bone from patients with osteoarthritis Open
Ageing of the skeleton is characterised by decreased bone mineral density, reduced strength, and increased risk of fracture. Although it is known that these changes are determined by the activities of bone cells through the processes of bo…