Anne-Kristin Stavrum
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View article: Sex-Specific Cord Blood DNA Methylation Signatures for Childhood ADHD Symptoms
Sex-Specific Cord Blood DNA Methylation Signatures for Childhood ADHD Symptoms Open
The underdiagnosis of Attention-Deficit/Hyperactivity Disorder (ADHD) in females, particularly those with the inattentive presentation, highlights a critical gap in clinical care. While DNA methylation may be tissue-specific, accessible pe…
View article: Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches
Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches Open
Background Genetic ancestry is an important factor to account for in DNA methylation studies because genetic variation influences DNA methylation patterns. One approach uses principal components (PCs) calculated from CpG sites that overlap…
View article: Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches
Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches Open
Background Genetic ancestry is an important factor to account for in DNA methylation studies because genetic variation influences DNA methylation patterns. One approach uses principal components (PCs) calculated from CpG sites that overlap…
View article: Differential DNA methylation and gene expression in stem cell-derived cardiomyocytes from patients with and without a history of clozapine-induced myocarditis
Differential DNA methylation and gene expression in stem cell-derived cardiomyocytes from patients with and without a history of clozapine-induced myocarditis Open
Clozapine is an effective antipsychotic medication for the management of treatment-resistant schizophrenia. However, the use of clozapine is limited due to severe and sometimes fatal adverse events, including cardiac inflammation (myocardi…
View article: Methylome-Wide Association Study of Obsessive-Compulsive Disorder
Methylome-Wide Association Study of Obsessive-Compulsive Disorder Open
Background Obsessive-compulsive disorder (OCD) is a debilitating psychiatric condition influenced by both genetic and environmental risk factors. Epigenetic modifications, such as DNA methylation, may offer insights into biologically meani…
View article: Optimizing Genetic Ancestry Adjustment in DNA Methylation Studies: A Comparative Analysis of Approaches
Optimizing Genetic Ancestry Adjustment in DNA Methylation Studies: A Comparative Analysis of Approaches Open
View article: Using LDpred2 to adapt polygenic risk score techniques for methylation score creation
Using LDpred2 to adapt polygenic risk score techniques for methylation score creation Open
View article: Using LDpred2 to Adapt Polygenic Risk Score Techniques for Methylation Score Creation
Using LDpred2 to Adapt Polygenic Risk Score Techniques for Methylation Score Creation Open
Objective: This study sought to determine if the R package LDpred2, designed for polygenic risk score creation for genome-wide association studies using summary statistics, could be adapted for deriving DNA methylation scores from methylom…
View article: Differential DNA Methylation and Gene Expression in Stem Cell-Derived Cardiomyocytes from Patients with and without a History of Clozapine-Induced Myocarditis.
Differential DNA Methylation and Gene Expression in Stem Cell-Derived Cardiomyocytes from Patients with and without a History of Clozapine-Induced Myocarditis. Open
Clozapine is an effective antipsychotic medication for the management of treatment-resistant schizophrenia. However, the use of clozapine is limited due to severe and sometimes fatal adverse events, including cardiac inflammation (myocardi…
View article: Sex effects on DNA methylation affect discovery in epigenome-wide association study of schizophrenia
Sex effects on DNA methylation affect discovery in epigenome-wide association study of schizophrenia Open
Sex differences in the epidemiology and clinical characteristics of schizophrenia are well-known; however, the molecular mechanisms underlying these differences remain unclear. Further, the potential advantages of sex-stratified meta-analy…
View article: Epigenome-Wide Association Studies in Cases and Controls With High and Low Genetic Risk for Schizophrenia
Epigenome-Wide Association Studies in Cases and Controls With High and Low Genetic Risk for Schizophrenia Open
Schizophrenia (SCZ) is a severe psychiatric disorder caused by a complex interplay of genetic and environmental factors. Genome-wide association studies (GWASs) have identified numerous genetic variants associated with SCZ, yet genetic ris…
View article: Divergent epigenetic responses to perinatal asphyxia in severe mental disorders
Divergent epigenetic responses to perinatal asphyxia in severe mental disorders Open
View article: Neurobiological mechanisms of ECT and TMS treatment in depression: study protocol of a multimodal magnetic resonance investigation
Neurobiological mechanisms of ECT and TMS treatment in depression: study protocol of a multimodal magnetic resonance investigation Open
Background Noninvasive neurostimulation treatments are increasingly being used to treat major depression, which is a common cause of disability worldwide. While electroconvulsive therapy (ECT) and transcranial magnetic stimulation (TMS) ar…
View article: Sex effects on DNA methylation affect discovery in epigenome-wide association study of schizophrenia
Sex effects on DNA methylation affect discovery in epigenome-wide association study of schizophrenia Open
Sex differences in the epidemiology and clinical characteristics of schizophrenia are well-known; however, the molecular mechanisms underlying these differences remain unclear. Further, the potential advantages of sex-stratified meta-analy…
View article: Neurobiological mechanisms of ECT and TMS treatment in depression. Study protocol of a multimodal magnetic resonance investigation
Neurobiological mechanisms of ECT and TMS treatment in depression. Study protocol of a multimodal magnetic resonance investigation Open
Background : Noninvasive neurostimulation treatments are increasingly being used to treat major depression, which is a common cause of disability worldwide. While electroconvulsive therapy (ECT) and transcranial magnetic stimulation (TMS) …
View article: Differences in white blood cell proportions between schizophrenia cases and controls are influenced by medication and variations in time of day
Differences in white blood cell proportions between schizophrenia cases and controls are influenced by medication and variations in time of day Open
View article: Divergent epigenetic responses to birth asphyxia in severe mental disorders
Divergent epigenetic responses to birth asphyxia in severe mental disorders Open
Epigenetic modifications influenced by environmental exposures are molecular sources of phenotypic heterogeneity found in schizophrenia and bipolar disorder and may contribute to shared etiopathogenetic mechanisms of these two disorders. N…
View article: An epigenetic association analysis of childhood trauma in psychosis reveals possible overlap with methylation changes associated with PTSD
An epigenetic association analysis of childhood trauma in psychosis reveals possible overlap with methylation changes associated with PTSD Open
Patients with a severe mental disorder report significantly higher levels of childhood trauma (CT) than healthy individuals. Studies have suggested that CT may affect brain plasticity through epigenetic mechanisms and contribute to develop…
View article: Cannabis Use Is Associated With Increased Levels of Soluble gp130 in Schizophrenia but Not in Bipolar Disorder
Cannabis Use Is Associated With Increased Levels of Soluble gp130 in Schizophrenia but Not in Bipolar Disorder Open
The complex effects of plant cannabinoids on human physiology is not yet fully understood, but include a wide spectrum of effects on immune modulation. The immune system and its inflammatory effector pathways are recently emerging as possi…
View article: Cannabis use is associated with increased levels of soluble gp130 in schizophrenia but not in bipolar disorder
Cannabis use is associated with increased levels of soluble gp130 in schizophrenia but not in bipolar disorder Open
The complex effects of plant cannabinoids on human physiology is not yet fully understood, but include a wide spectrum of effects on immune modulation. The immune system and its inflammatory effector pathways are recently emerging as possi…
View article: Functional analysis of evolutionary human methylated regions in schizophrenia patients
Functional analysis of evolutionary human methylated regions in schizophrenia patients Open
Background Recent studies have implicated variations in DNA methylation in the aetiology of schizophrenia. Genome-wide scans in both brain and blood report differential methylated regions (DMRs) and positions (DMPs) between patients with s…
View article: Gene Expression Response in Peripheral Blood Cells of Petroleum Workers Exposed to Sub-Ppm Benzene Levels
Gene Expression Response in Peripheral Blood Cells of Petroleum Workers Exposed to Sub-Ppm Benzene Levels Open
Altered gene expression in pathways relevant to leukaemogenesis, as well as reduced levels of circulating lymphocytes, have been reported in workers that were exposed to benzene concentrations below 1 ppm. In this study, we analysed whole …
View article: SBMLmod: a Python-based web application and web service for efficient data integration and model simulation
SBMLmod: a Python-based web application and web service for efficient data integration and model simulation Open