Anne Labonté
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View article: Uncovering atrophy progression pattern and mechanisms in individuals at risk of Alzheimer's disease
Uncovering atrophy progression pattern and mechanisms in individuals at risk of Alzheimer's disease Open
Alzheimer's disease is associated with pre-symptomatic changes in brain morphometry and accumulation of abnormal tau and amyloid-beta pathology. Studying the development of brain changes prior to symptoms onset may lead to early diagnostic…
View article: SCARF2 in the CSF of Asymptomatic subjects With a Parental History of AD and in the Cortex of Autopsy‐Confirmed Alzheimer’s Disease Cases
SCARF2 in the CSF of Asymptomatic subjects With a Parental History of AD and in the Cortex of Autopsy‐Confirmed Alzheimer’s Disease Cases Open
Background Scavenger receptors (SR) are a group of receptors involved in the endocytosis of various ligands, such as modified LDL and soluble β‐amyloid, which connects them to Alzheimer’s disease (AD). SCARF2 (SREC‐II) is part of the SR fa…
View article: Synaptic proteins in pre‐symptomatic Alzheimer's disease: genes implicate synaptic biomarkers to the early detection of cognitive decline
Synaptic proteins in pre‐symptomatic Alzheimer's disease: genes implicate synaptic biomarkers to the early detection of cognitive decline Open
Background The heterogeneous etiology of “sporadic” Alzheimer’s disease (sAD) includes genetic influences. To better understand synaptic dysfunction in AD pathogenesis, we used protein quantitative train loci (pQTL) assessments and a polyg…
View article: Longitudinal association between CSF markers of Alzheimer Disease and inflammation in preclinical Alzheimer Disease
Longitudinal association between CSF markers of Alzheimer Disease and inflammation in preclinical Alzheimer Disease Open
Background Inflammation is central to Alzheimer Disease (AD), as astrocyte reactivity accompanies the appearance of Aβ and phosphorylated tau (Bellaver et al., 2023). As expected, therefore, AD patients have elevated levels of CSF inflamma…
View article: The role of clusterin and the variant rs11136000_T throughout the spectrum of Alzheimer’s disease
The role of clusterin and the variant rs11136000_T throughout the spectrum of Alzheimer’s disease Open
Background Clusterin is a major cholesterol transporter in the central nervous system (CNS) and different SNPs in the CLU gene have been associated with Alzheimer’s disease (AD) risk. The rs11136000_T variant in the CLU gene has been shown…
View article: PTPRS is a novel marker for early tau pathology and synaptic integrity in Alzheimer’s disease
PTPRS is a novel marker for early tau pathology and synaptic integrity in Alzheimer’s disease Open
Background Synaptic dysfunction is a central pathologic feature of Alzheimer’s disease (AD), with synaptic loss even preceding neuronal loss in specific brain regions. In healthy individuals, synaptic function and plasticity are orchestrat…
View article: Complement proteins C1q, C3, and Factor H are associated with early tau pathology and synaptic integrity in persons with pre‐symptomatic Alzheimer’s disease
Complement proteins C1q, C3, and Factor H are associated with early tau pathology and synaptic integrity in persons with pre‐symptomatic Alzheimer’s disease Open
Background The immune complement system is key to the elimination of redundant neural connections in the brain through a process called synaptic pruning. In neurodegenerative diseases such as Alzheimer's disease (AD), this system may resul…
View article: Apolipoprotein B gene expression and regulation in relation to Alzheimer’s disease pathophysiology
Apolipoprotein B gene expression and regulation in relation to Alzheimer’s disease pathophysiology Open
Apolipoprotein B (APOB), a receptor-binding protein present in cholesterol-rich lipoproteins, has been implicated in Alzheimer's disease (AD). High levels of APOB-containing low-density lipoproteins (LDL) are linked to the pathogenesis of …
View article: Associations between neuromelanin depletion and cortical rhythmic activity in Parkinson’s disease
Associations between neuromelanin depletion and cortical rhythmic activity in Parkinson’s disease Open
Parkinson’s disease (PD) is marked by the death of neuromelanin-rich dopaminergic and noradrenergic cells in the substantia nigra (SN) and the locus coeruleus (LC), respectively, resulting in motor and cognitive impairments. Although SN do…
View article: Osteopontin: A novel marker of pre‐symptomatic sporadic Alzheimer's disease
Osteopontin: A novel marker of pre‐symptomatic sporadic Alzheimer's disease Open
INTRODUCTION We investigate the role of osteopontin (OPN) in participants with Pre‐symptomatic Alzheimer's disease (AD), mild cognitive impairment (MCI), and in AD brains. METHODS Cerebrospinal fluid (CSF) OPN, AD, and synaptic biomarker l…
View article: Locus coeruleus integrity is related to an exploitation-based decision-making bias in older adulthood
Locus coeruleus integrity is related to an exploitation-based decision-making bias in older adulthood Open
Optimal decision-making balances exploration for new information against exploitation of known rewards, a process mediated by the locus coeruleus and its norepinephrine projections. We predicted that an exploitation-bias that emerges in ol…
View article: PTPRS is a novel marker for early tau pathology and synaptic integrity in Alzheimer’s disease
PTPRS is a novel marker for early tau pathology and synaptic integrity in Alzheimer’s disease Open
We examined the role of protein tyrosine phosphatase receptor sigma (PTPRS) in the context of Alzheimer’s disease and synaptic integrity. Publicly available datasets (BRAINEAC, ROSMAP, ADC1) and a cohort of asymptomatic but “at risk” indiv…
View article: Neurobehavioral Mechanisms Influencing the Association Between Generativity, the Desire to Promote Well-Being of Younger Generations, and Purpose in Life in Older Adults at Risk for Alzheimer’s Disease
Neurobehavioral Mechanisms Influencing the Association Between Generativity, the Desire to Promote Well-Being of Younger Generations, and Purpose in Life in Older Adults at Risk for Alzheimer’s Disease Open
Objectives Generativity, the desire and action to improve the well-being of younger generations, is associated with purpose in life among older adults. However, the neurobehavioral factors supporting the relationship between generativity a…
View article: Longer sleep duration and neuroinflammation in at-risk elderly with a parental history of Alzheimer’s disease
Longer sleep duration and neuroinflammation in at-risk elderly with a parental history of Alzheimer’s disease Open
Study Objectives Although short sleep could promote neurodegeneration, long sleep may be a marker of ongoing neurodegeneration, potentially as a result of neuroinflammation. The objective was to evaluate sleep patterns with age of expected…
View article: Day‐to‐day sleep variability with Alzheimer's biomarkers in at‐risk elderly
Day‐to‐day sleep variability with Alzheimer's biomarkers in at‐risk elderly Open
INTRODUCTION Measuring day‐to‐day sleep variability might reveal unstable sleep‐wake cycles reflecting neurodegenerative processes. We evaluated the association between Alzheimer's disease (AD) fluid biomarkers with day‐to‐day sleep variab…
View article: Synaptic proteins in pre‐symptomatic Alzheimer’s disease: biomarkers for early detection of Cognitive Decline
Synaptic proteins in pre‐symptomatic Alzheimer’s disease: biomarkers for early detection of Cognitive Decline Open
Background Synaptic proteins in the cerebrospinal fluid (CSF) may reveal changes in the pre‐symptomatic stages of Alzheimer’s disease (AD), thus may be candidate biomarkers for early detection of the disease. Method The PREVENT‐AD cohort i…
View article: Osteopontin exhibits a bidirectional relationship with Alzheimer’s disease pathology in asymptomatic individuals with a parental history of sporadic Alzheimer’s disease
Osteopontin exhibits a bidirectional relationship with Alzheimer’s disease pathology in asymptomatic individuals with a parental history of sporadic Alzheimer’s disease Open
Background Osteopontin (OPN) is a secreted protein that plays pivotal roles in the recruitment and activation of immune cells, cell survival, and tissue repair following injury. OPN has been demonstrated to be increased in the cerebrospina…
View article: Unique CSF lipid signature in asymptomatic subjects with a parental history of Alzheimer’s disease and its association with key apolipoprotein species
Unique CSF lipid signature in asymptomatic subjects with a parental history of Alzheimer’s disease and its association with key apolipoprotein species Open
Background CSF apolipoproteins exhibit lipid‐specific relationships (signatures) with Alzheimer’s disease (AD) pathological markers and APOE ‐ε4 in asymptomatic individuals. Method Mass spectrometry‐based CSF lipid analysis was performed a…
View article: Evaluation of HIVEP3 polymorphic variants and gene expression in Alzheimer’s disease
Evaluation of HIVEP3 polymorphic variants and gene expression in Alzheimer’s disease Open
Background It has been increasingly recognized that neuroinflammation plays an important role in the pathophysiology of Alzheimer’s disease (AD). The HIVEP3 gene encodes a transcription factor that regulates inflammatory response, and vari…
View article: Day‐to‐day Sleep Variability in Val66Met BDNF Carriers: A Potential Biological Pathway Between BDNF Activity and Alzheimer’s Disease Pathology?
Day‐to‐day Sleep Variability in Val66Met BDNF Carriers: A Potential Biological Pathway Between BDNF Activity and Alzheimer’s Disease Pathology? Open
Background We previously showed that day‐to‐day sleep variability was associated with biomarkers of Alzheimer’s disease (AD) pathology. Given that brain‐derived neurotrophic factor (BDNF) activity has been involved in both AD and cognitive…
View article: Insulin-like growth factor binding protein-2 in at-risk adults and autopsy-confirmed Alzheimer brains
Insulin-like growth factor binding protein-2 in at-risk adults and autopsy-confirmed Alzheimer brains Open
Insulin, insulin-like growth factors (IGF) and their receptors are highly expressed in the adult hippocampus. Thus, disturbances in the insulin-IGF signalling pathway may account for the selective vulnerability of the hippocampus to nascen…
View article: Day‐to‐day sleep and circadian variability in association with Alzheimer’s Disease biomarkers
Day‐to‐day sleep and circadian variability in association with Alzheimer’s Disease biomarkers Open
Background Increasing evidence shows that Alzheimer’s Disease (AD) pathology, i.e., the Aß peptide, tau tangles and the APOEε4 allele, have all been associated with disrupted sleep and change in circadian rhythms. However, objective sleep …
View article: Actigraphy sleep patterns in presymptomatic Alzheimer’s Disease: the potential role of neuroinflammation
Actigraphy sleep patterns in presymptomatic Alzheimer’s Disease: the potential role of neuroinflammation Open
Background Both short and long sleep duration have been associated with increased risk of developing Alzheimer’s Disease (AD). While short sleep has been hypothesized to be a risk factor promoting neurodegenerative processes. Long sleep ha…
View article: Assessment of white matter hyperintensity severity using multimodal magnetic resonance imaging
Assessment of white matter hyperintensity severity using multimodal magnetic resonance imaging Open
White matter hyperintensities are radiological abnormalities reflecting cerebrovascular dysfunction detectable using MRI. White matter hyperintensities are often present in individuals at the later stages of the lifespan and in prodromal s…
View article: Characterization of the contactin 5 protein and its risk‐associated polymorphic variant throughout the Alzheimer's disease spectrum
Characterization of the contactin 5 protein and its risk‐associated polymorphic variant throughout the Alzheimer's disease spectrum Open
Introduction We investigate the CNTN5 rs1461684 G variant and the contactin 5 protein in sporadic Alzheimer's disease (sAD). Methods Contactin 5, sAD biomarkers, and synaptic markers were measured in the cerebrospinal fluid (CSF). Amyloid …
View article: The role of IGFBP2 in pre‐symptomatic Alzheimer's disease: a multimodal longitudinal study of cognitively unaffected individuals with a family history of sporadic Alzheimer’s disease
The role of IGFBP2 in pre‐symptomatic Alzheimer's disease: a multimodal longitudinal study of cognitively unaffected individuals with a family history of sporadic Alzheimer’s disease Open
Background Insulin‐like growth factors (IGF) play pivotal roles in neurogenesis, neuronal survival, synaptogenesis and compensatory repair mechanisms following injury. Insulin‐like growth factor binding proteins (IGFBP) bind to IGFs, and r…
View article: Spatial Extent of Amyloid-β Levels and Associations With Tau-PET and Cognition
Spatial Extent of Amyloid-β Levels and Associations With Tau-PET and Cognition Open
Importance Preventive trials of anti-amyloid agents might preferably recruit persons showing earliest biologically relevant β-amyloid (Aβ) binding on positron emission tomography (PET). Objective To investigate the timing at which Aβ-PET b…