Anne Lethaby
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View article: Long-term hormone therapy for perimenopausal and postmenopausal women
Long-term hormone therapy for perimenopausal and postmenopausal women Open
Long-term follow-up of women using hormone therapy suggests that the risk profiles vary between combined hormone therapy and oestrogen-only therapy. Oestrogen-only hormone therapy probably makes little to no difference to coronary events, …
View article: Preoperative medical therapy before surgery for uterine fibroids
Preoperative medical therapy before surgery for uterine fibroids Open
Pretreatment with gonadotropin-hormone-releasing analogues may reduce uterine and fibroid volume and probably increases preoperative haemoglobin levels, but probably also increases the number of adverse events. Blood transfusions and opera…
View article: Interventions for heavy menstrual bleeding; overview of Cochrane reviews and network meta-analysis
Interventions for heavy menstrual bleeding; overview of Cochrane reviews and network meta-analysis Open
Evidence suggests LNG-IUS is the best first-line treatment for reducing menstrual blood loss (MBL); antifibrinolytics are probably the second best, and long-cycle progestogens are likely the third best. We cannot make conclusions about the…
View article: Interventions commonly available during pandemics for heavy menstrual bleeding: an overview of Cochrane Reviews
Interventions commonly available during pandemics for heavy menstrual bleeding: an overview of Cochrane Reviews Open
There is moderate-certainty evidence that antifibrinolytics and combined hormonal contraceptives reduce heavy menstrual bleeding compared with placebo. There is low-certainty evidence that NSAIDs reduce heavy menstrual bleeding compared wi…
View article: Interventions commonly available during pandemics for heavy menstrual bleeding: an overview of Cochrane Reviews
Interventions commonly available during pandemics for heavy menstrual bleeding: an overview of Cochrane Reviews Open
This is a protocol for a Cochrane Review (overview). The objectives are as follows: To summarise the evidence from Cochrane Reviews evaluating interventions for heavy menstrual bleeding that are commonly available during pandemics.
View article: Endometrial resection and ablation versus hysterectomy for heavy menstrual bleeding
Endometrial resection and ablation versus hysterectomy for heavy menstrual bleeding Open
Endometrial resection and ablation offers an alternative to hysterectomy as a surgical treatment for heavy menstrual bleeding. Both procedures are effective, and satisfaction rates are high. Although hysterectomy offers permanent and immed…
View article: Combined hormonal contraceptives for heavy menstrual bleeding
Combined hormonal contraceptives for heavy menstrual bleeding Open
Moderate-quality evidence suggests that the combined oral contraceptive pill over six months reduces HMB in women with unacceptable HMB from 12% to 77% (compared to 3% in women taking placebo). When compared with other medical options for …
View article: Antibiotics for treating urogenital <i>Chlamydia trachomatis</i> infection in men and non-pregnant women
Antibiotics for treating urogenital <i>Chlamydia trachomatis</i> infection in men and non-pregnant women Open
In men, regimens with azithromycin are probably less effective than doxycycline for microbiological failure, however, there might be little or no difference for clinical failure. For women, we are uncertain whether azithromycin compared to…
View article: Endometrial resection and ablation techniques for heavy menstrual bleeding
Endometrial resection and ablation techniques for heavy menstrual bleeding Open
Background Heavy menstrual bleeding (HMB) is a significant health problem in premenopausal women; it can reduce their quality of life and can cause social disruption and physical problems such as iron deficiency anaemia. First‐line treatme…
View article: Interventions for the treatment of heavy menstrual bleeding
Interventions for the treatment of heavy menstrual bleeding Open
This is a protocol for a Cochrane Review (Overview). The objectives are as follows: To identify, systematically assess and summarise all evidence from Cochrane Reviews on treatment for heavy menstrual bleeding (HMB), through a network meta…
View article: Antifibrinolytics for heavy menstrual bleeding
Antifibrinolytics for heavy menstrual bleeding Open
Antifibrinolytic treatment (such as TXA) appears effective for treating HMB compared to placebo, NSAIDs, oral luteal progestogens, ethamsylate, or herbal remedies, but may be less effective than LIUS. There were too few data for most compa…
View article: Preoperative medical therapy before surgery for uterine fibroids
Preoperative medical therapy before surgery for uterine fibroids Open
A rationale for the use of preoperative medical therapy before surgery for fibroids is to make surgery easier. There is clear evidence that preoperative GnRHa reduces uterine and fibroid volume, and increases preoperative haemoglobin level…
View article: Oral contraceptive pill, progestogen or oestrogen pretreatment for ovarian stimulation protocols for women undergoing assisted reproductive techniques
Oral contraceptive pill, progestogen or oestrogen pretreatment for ovarian stimulation protocols for women undergoing assisted reproductive techniques Open
Among women undergoing ovarian stimulation in antagonist protocols, COCP pretreatment was associated with a lower rate of live birth or ongoing pregnancy than no pretreatment. There was insufficient evidence to determine whether rates of l…
View article: Long-term hormone therapy for perimenopausal and postmenopausal women
Long-term hormone therapy for perimenopausal and postmenopausal women Open
BACKGROUND: Hormone therapy (HT) is widely provided for control of menopausal symptoms and has been used for the management and prevention of cardiovascular disease, osteoporosis and dementia in older women. This is an updated version of a…
View article: Local oestrogen for vaginal atrophy in postmenopausal women
Local oestrogen for vaginal atrophy in postmenopausal women Open
There was no evidence of a difference in efficacy between the various intravaginal oestrogenic preparations when compared with each other. However, there was low-quality evidence that intra-vaginal oestrogenic preparations improve the symp…
View article: High-dose chemotherapy and autologous bone marrow or stem cell transplantation versus conventional chemotherapy for women with early poor prognosis breast cancer
High-dose chemotherapy and autologous bone marrow or stem cell transplantation versus conventional chemotherapy for women with early poor prognosis breast cancer Open
There is high-quality evidence of increased treatment-related mortality and little or no increase in survival by using high-dose chemotherapy with autograft for women with early poor prognosis breast cancer.
View article: Surgery versus medical therapy for heavy menstrual bleeding
Surgery versus medical therapy for heavy menstrual bleeding Open
Surgery, especially hysterectomy, reduces menstrual bleeding more than medical treatment at one year. There is no conclusive evidence of a difference in satisfaction rates between surgery and LNG-IUS, though adverse effects such as bleedin…