Anne Linhardt
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View article: Degradable, Dendritic Polyols on a Branched Polyphosphazene Backbone
Degradable, Dendritic Polyols on a Branched Polyphosphazene Backbone Open
Herein, we present the design, synthesis, and characterization of fully degradable, hybrid, star-branched dendritic polyols. First multiarmed polyphosphazenes were prepared as a star-branched scaffold which upon functionalization produced …
View article: Cover Feature: A pH‐sensitive Macromolecular Prodrug as TLR7/8 Targeting Immune Response Modifier (Chem. Eur. J. 70/2017)
Cover Feature: A pH‐sensitive Macromolecular Prodrug as TLR7/8 Targeting Immune Response Modifier (Chem. Eur. J. 70/2017) Open
The chemical synthesis and biological activity of new functionalized imidazoquinoline derivatives (ImQ) to generate Toll-like receptor (TLR) 7/8 specific prodrugs are presented. In vivo activity of ImQs to induce inflammation was confirmed…
View article: A pH‐sensitive Macromolecular Prodrug as TLR7/8 Targeting Immune Response Modifier
A pH‐sensitive Macromolecular Prodrug as TLR7/8 Targeting Immune Response Modifier Open
The chemical synthesis and biological activity of novel functionalized imidazoquinoline derivatives (ImQ) to generate Toll‐like receptor (TLR) 7/8 specific prodrugs are presented. In vivo activity of ImQs to induce inflammation was confirm…
View article: Biodegradable Polyphosphazene Based Peptide-Polymer Hybrids
Biodegradable Polyphosphazene Based Peptide-Polymer Hybrids Open
A novel series of peptide based hybrid polymers designed to undergo enzymatic degradation is presented, via macrosubstitution of a polyphosphazene backbone with the tetrapeptide Gly-Phe-Leu-Gly. Further co-substitution of the hybrid polyme…