Anne Marie Minihane
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View article: Supplementary Table 1 from Polymorphisms in <i>Cyclooxygenase</i>, <i>Lipoxygenase</i>, and <i>TP53</i> Genes Predict Colorectal Polyp Risk Reduction by Aspirin in the seAFOod Polyp Prevention Trial
Supplementary Table 1 from Polymorphisms in <i>Cyclooxygenase</i>, <i>Lipoxygenase</i>, and <i>TP53</i> Genes Predict Colorectal Polyp Risk Reduction by Aspirin in the seAFOod Polyp Prevention Trial Open
Supplementary Table 1 shows the list of SNPs that were analysed by the Fluidigm assay.
View article: Supplementary Figure 2 from Polymorphisms in <i>Cyclooxygenase</i>, <i>Lipoxygenase</i>, and <i>TP53</i> Genes Predict Colorectal Polyp Risk Reduction by Aspirin in the seAFOod Polyp Prevention Trial
Supplementary Figure 2 from Polymorphisms in <i>Cyclooxygenase</i>, <i>Lipoxygenase</i>, and <i>TP53</i> Genes Predict Colorectal Polyp Risk Reduction by Aspirin in the seAFOod Polyp Prevention Trial Open
Supplementary Figure 2 shows the distribution of individual total (combined adenomatous and serrated polyp) colorectal polyp counts according to seAFOod trial treatment allocation by factorial margins and ALOX SNP genotypes.
View article: Continuous Glucose Monitoring in Older People With Diabetes Mellitus and Cognitive Impairment: A Brief Review
Continuous Glucose Monitoring in Older People With Diabetes Mellitus and Cognitive Impairment: A Brief Review Open
Background: Diabetes mellitus and dementia are common chronic diseases affecting older people in the community and in hospitals. Even though both diseases have been independently well-characterized, comorbid diabetes and dementia/cognitive…
View article: The cost of a Mediterranean Diet and walking intervention to reduce risk of dementia and improve quality of life in independent living populations in Australia: The MedWalk randomised controlled trial
The cost of a Mediterranean Diet and walking intervention to reduce risk of dementia and improve quality of life in independent living populations in Australia: The MedWalk randomised controlled trial Open
There is growing evidence that optimising dietary quality and engaging in physical activity (PA) can reduce dementia and cognitive decline risk and improve psychosocial health and quality of life (QoL). Multimodal interventions focusing on…
View article: Remote, lower-intensity, multidomain lifestyle intervention for subjective cognitive decline or mild cognitive impairment (APPLE-Tree): a multicentre, single-masked, randomised controlled trial
Remote, lower-intensity, multidomain lifestyle intervention for subjective cognitive decline or mild cognitive impairment (APPLE-Tree): a multicentre, single-masked, randomised controlled trial Open
Economic and Social Research Council and National Institute for Health and Care Research programme grant.
View article: Awareness, facilitators, barriers, and behaviours surrounding brain health: a large-scale cross-sectional survey of adults across UK and Ireland
Awareness, facilitators, barriers, and behaviours surrounding brain health: a large-scale cross-sectional survey of adults across UK and Ireland Open
Background Almost half of all dementia cases could theoretically be delayed or prevented by addressing risk factors at the population level. However, dementia risk reduction requires awareness of, and action on, modifiable risk factors. Th…
View article: Impact of whey protein-enriched milk fat globule membrane supplementation on fasting circulating lipid and glucose parameters in middle-to-older aged adults at moderate cardiovascular disease risk: preliminary insights from a randomised controlled trial
Impact of whey protein-enriched milk fat globule membrane supplementation on fasting circulating lipid and glucose parameters in middle-to-older aged adults at moderate cardiovascular disease risk: preliminary insights from a randomised controlled trial Open
Functional dairy-derived ingredients, including whey protein (WP) and milk fat globule membrane (MFGM), have the potential to improve markers of cardiovascular disease (CVD) and broader cardiometabolic disease risk (1,2) . WP supplementati…
View article: Hormone replacement therapy and dementia risk among postmenopausal women: evidence from the UK Biobank
Hormone replacement therapy and dementia risk among postmenopausal women: evidence from the UK Biobank Open
Importance The relationship between HRT use and dementia risk is unclear, with studies reporting both increased and decreased risk. Objective To identify modulators of the association between HRT use and dementia risk and identify potentia…
View article: Inequity and food insecurity and effects on obesity and associated co-morbidities: meeting report and research priorities
Inequity and food insecurity and effects on obesity and associated co-morbidities: meeting report and research priorities Open
A Rank Forum was convened to discuss the evidence around food insecurity (FIS), its impact on health, and interventions which could make a difference both at individual and societal level, with a focus on the UK. This paper summarises the …
View article: <i>APOE4</i> genotype shapes the role of dietary fibers in cognitive health through gut microbiota changes
<i>APOE4</i> genotype shapes the role of dietary fibers in cognitive health through gut microbiota changes Open
APOE4, a key risk factor for Alzheimer's disease, influences gut microbiota and microbial metabolites (e.g. amino acids and dietary fiber (DF) derived short-chain fatty acids (SCFAs)). However, its role in modulating microbiota-driv…
View article: Sustainable and available sources of omega-3 fatty acids for health: are the current dietary recommendations, food sources and legislation fit for purpose?
Sustainable and available sources of omega-3 fatty acids for health: are the current dietary recommendations, food sources and legislation fit for purpose? Open
The health benefits of the long-chain omega-3 polyunsaturated fatty acids (PUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been known for over 50 years and underpin the UK population recommendation to consume >450 mg…
View article: Omega-3 fatty acids, brain health and the menopause
Omega-3 fatty acids, brain health and the menopause Open
The menopausal transition is associated with vasomotor symptoms, disrupted sleep, transient cognitive deficits and changes in mood and anxiety levels, underpinned by declining and erratic estrogen availability in the brain. Relative to oth…
View article: Effect of age and sex on the urinary elimination of a single dose of mixed flavonoids: results from a single-arm intervention in healthy United Kingdom adults
Effect of age and sex on the urinary elimination of a single dose of mixed flavonoids: results from a single-arm intervention in healthy United Kingdom adults Open
View article: The gut microbiota in menopause: Is there a role for prebiotic and probiotic solutions?
The gut microbiota in menopause: Is there a role for prebiotic and probiotic solutions? Open
The gut microbiota, comprising a diverse array of microorganisms in the gastrointestinal tract, has emerged as a key player in human health. Emerging research indicates that this gut microbial composition is influenced by sex. These sex di…
View article: Delphi survey to gather feedback on a CONSORT extension proposal for nutrition intervention trials
Delphi survey to gather feedback on a CONSORT extension proposal for nutrition intervention trials Open
View article: The association between medication use and lifestyle factors in independently living older people: impact of Mediterranean diet and physical activity
The association between medication use and lifestyle factors in independently living older people: impact of Mediterranean diet and physical activity Open
In this cross-sectional study, higher PA was consistently associated with reduced polypharmacy and fewer medications, while greater MedDiet adherence was linked to reduced use of metabolic medications. Lifestyle practices may influence med…
View article: Effectiveness and feasibility of a theory-informed intervention to improve Mediterranean diet adherence, physical activity and cognition in older adults at risk of dementia: the MedEx-UK randomised controlled trial
Effectiveness and feasibility of a theory-informed intervention to improve Mediterranean diet adherence, physical activity and cognition in older adults at risk of dementia: the MedEx-UK randomised controlled trial Open
Background Despite an urgent need for multi-domain lifestyle interventions to reduce dementia risk, there is a lack of interventions which are informed by theory- and evidence-based behaviour change strategies, and no interventions in this…
View article: From ocean to emotion: a pilot study exploring acute mood effects following consumption of a DHA-rich powder compared with placebo in middle-aged Australian men
From ocean to emotion: a pilot study exploring acute mood effects following consumption of a DHA-rich powder compared with placebo in middle-aged Australian men Open
While there is evidence that long-chain n -3 PUFA supplementation benefits mood, the extent to which a single high dose of n -3 PUFA can induce acute mood effects has not been examined. The present study investigated whether a single dose …
View article: Acute effect of a Mediterranean-style dietary pattern (MDP) on mood, anxiety and cognition in UK adults with mild to moderate anxiety and depression: the MediMood randomised controlled trial protocol
Acute effect of a Mediterranean-style dietary pattern (MDP) on mood, anxiety and cognition in UK adults with mild to moderate anxiety and depression: the MediMood randomised controlled trial protocol Open
Introduction Psychological disorders including depression and anxiety are significant public health concerns. A Mediterranean-style dietary pattern (MDP) has been associated with improved mental well-being in observational studies. Evidenc…
View article: The association between selenium status and global and attention-specific cognition in very old adults in the Newcastle 85+ Study: cross-sectional and longitudinal analyses
The association between selenium status and global and attention-specific cognition in very old adults in the Newcastle 85+ Study: cross-sectional and longitudinal analyses Open
There were no associations between selenium status and cognitive decline. However, serum selenium, but not SELENOP or GPx3 activity, was positively associated nonlinearly with global cognition at baseline. Furthermore, these associations w…
View article: Circulatory dietary and gut-derived metabolites predict preclinical Alzheimer’s disease
Circulatory dietary and gut-derived metabolites predict preclinical Alzheimer’s disease Open
A key component of disease prevention is the identification of at-risk individuals. Microbial dysbiosis and microbe-derived metabolites (MDM) can influence the central nervous system, but their role in disease progression and as prognostic…
View article: Effects of the COVID-19 associated United Kingdom lockdown on physical activity in older adults at high risk of cardiovascular disease: a mixed methods perspective from the MedEx-UK multicenter trial
Effects of the COVID-19 associated United Kingdom lockdown on physical activity in older adults at high risk of cardiovascular disease: a mixed methods perspective from the MedEx-UK multicenter trial Open
Introduction Physical inactivity and sedentary behaviour are linked to increased risk of cardiovascular disease, infections and dementia, as well as placing a significant economic burden on healthcare systems. The implementation of COVID-1…
View article: Towards consistency in dietary pattern scoring: standardising scoring workflows for healthy dietary patterns using 24-h recall and two variations of a food frequency questionnaire – CORRIGENDUM
Towards consistency in dietary pattern scoring: standardising scoring workflows for healthy dietary patterns using 24-h recall and two variations of a food frequency questionnaire – CORRIGENDUM Open
View article: Adherence to the Eatwell Guide and cardiometabolic, cognitive and neuroimaging parameters: an analysis from the PREVENT dementia study
Adherence to the Eatwell Guide and cardiometabolic, cognitive and neuroimaging parameters: an analysis from the PREVENT dementia study Open
Background The Eatwell guide reflects the UK government's recommendations for a healthy and balanced diet. Previous research has identified associations between healthy eating patterns and both cardiovascular and brain health, although the…
View article: Chronic and postprandial effect of blueberries on cognitive function, alertness, and mood in participants with metabolic syndrome – results from a six-month, double-blind, randomized controlled trial
Chronic and postprandial effect of blueberries on cognitive function, alertness, and mood in participants with metabolic syndrome – results from a six-month, double-blind, randomized controlled trial Open
Although self-rated calmness improved postprandially, and significant cognition-metabolite associations were identified, our data did not support strong cognitive, mood, alertness, or sleep quality improvements in MetS participants after b…
View article: Investigating the synergistic effects of hormone replacement therapy, <scp>apolipoprotein E</scp> and age on brain health in the <scp>UK</scp> Biobank
Investigating the synergistic effects of hormone replacement therapy, <span>apolipoprotein E</span> and age on brain health in the <span>UK</span> Biobank Open
Global prevalence of Alzheimer's Disease has a strong sex bias, with women representing approximately two‐thirds of the patients. Yet, the role of sex‐specific risk factors during midlife, including hormone replacement therapy (HRT) and th…
View article: APOE genotype, eicosapentaenoic acid (EPA) supplementation and n-3 highly unsaturated fatty acid (HUFA) levels in patients with multiple colorectal polyps: A secondary analysis of the seAFOod polyp prevention trial
APOE genotype, eicosapentaenoic acid (EPA) supplementation and n-3 highly unsaturated fatty acid (HUFA) levels in patients with multiple colorectal polyps: A secondary analysis of the seAFOod polyp prevention trial Open
APOE genotype is associated with differential n-3 HUFA and 18-HEPE levels in individuals with multiple colorectal polyps.
View article: Adherence to the Eatwell Guide and population and planetary health: A Rank Prize Forum report
Adherence to the Eatwell Guide and population and planetary health: A Rank Prize Forum report Open
This report summarises a Forum conducted in June 2023 to explore the current state of the knowledge around the Eatwell Guide, which is the UK government's healthy eating tool, in relation to population and planetary health. The 1.5‐day For…
View article: Towards consistency in dietary pattern scoring: standardising scoring workflows for healthy dietary patterns using 24-h recall and two variations of a food frequency questionnair
Towards consistency in dietary pattern scoring: standardising scoring workflows for healthy dietary patterns using 24-h recall and two variations of a food frequency questionnair Open
Healthy dietary patterns such as the Mediterranean diet (MeDi), Dietary Approaches to Stop Hypertension (DASH) and the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) have been evaluated for their potential association w…
View article: Subtle Blood Brain Barrier Leakage Quantification Using Dce-Mri in Subjective and Mild Cognitive Impairment: A Pilot Sub-Study of the Cognitive Ageing, Nutrition & Neurogenesis (Cann) Trial
Subtle Blood Brain Barrier Leakage Quantification Using Dce-Mri in Subjective and Mild Cognitive Impairment: A Pilot Sub-Study of the Cognitive Ageing, Nutrition & Neurogenesis (Cann) Trial Open