Explanipedia

Decitabine conditioning improves NK cell maturation and limits CD8+ T cell terminal differentiation post-alloSCT in acute myeloid leukemia patients Open

Diede van Ens, A. M. Grotens, Nicholas Dubois, Daan Heister, Nicolaas Schaap , et al. · 2025

Overall, addition of DAC to the conditioning regimen was associated with favorable immunomodulatory effects on NK and T cells post-alloSCT in AML patients. These findings suggest that DAC may enhance donor NK and T cell-mediated graft-vers…

Maternal blood glucose level is correlated to offspring brain fatty acid composition in a mouse model for gestational diabetes mellitus Open

Lidewij Schipper, Nicolaas Schaap, Yixian Liu, Hongyu Li, Weiping Han , et al. · 2025

Gestational diabetes mellitus (GDM) may increase the risk of suboptimal neurocognitive development in infants. Maternal supply of omega-3 and -6 long chain polyunsaturated fatty acids (LCPUFAs), including eicosapentaeonic acid, docosahexae…

Impact of shared HLA determinants between patient and losing cord blood unit on relapse after double cord blood transplantation Open

Robert Wynn, Fernanda Volt, Philippe Guardiola, Srividhya Senthil, Graziana Maria Scigliuolo , et al. · 2025

During double umbilical cord blood transplant (DUCBT), the winning unit (WU) rejects the losing unit (LU) because of WU T cells directed against the LU mismatched HLA. This immune response might protect against relapse, especially when the…

Intraperitoneal Infusion of Stem Cell-Derived Natural Killer Cells in Recurrent Epithelial Ovarian Cancer Patients: Results of the Phase 1 INTRO-01 Trial Open

Janneke Hoogstad, Paul K.J.D. de Jonge, Petra L.M. Zusterzeel, Willemijn Hobo, Anniek van der Waart , et al. · 2025

Interleukin-1β induces trained innate immunity in human hematopoietic progenitor cells in vitro Open

Daniela Flores-Gomez, Willemijn Hobo, Diede van Ens, Elise L. Kessler, Boris Novakovic , et al. · 2024

Innate immune cells can develop a long-lasting hyperresponsive phenotype, termed trained immunity, mediated by epigenetic and metabolic reprogramming. In mice, exposure to Bacille Calmette-Guérin (BCG), β-glucan, or Western diet induces tr…

Increased peritoneal TGF-β1 is associated with ascites-induced NK-cell dysfunction and reduced survival in high-grade epithelial ovarian cancer Open

Ralph J. A. Maas, Janneke S. Hoogstad‐van Evert, Iris M. Hagemans, Jolanda Brummelman, Diede van Ens , et al. · 2024

Natural killer (NK) cell therapy represents an attractive immunotherapy approach against recurrent epithelial ovarian cancer (EOC), as EOC is sensitive to NK cell-mediated cytotoxicity. However, NK cell antitumor activity is dampened by su…

Autologous stem cell transplantation in T-cell/histiocyte-rich large B-cell lymphoma: EBMT Lymphoma Working Party study Open

Simon Renders, Maud Ngoya, Hervé Finel, Marie-Thérèse Rubio, William Townsend , et al. · 2024

Although broadly used, consolidative autologous hematopoietic stem cell transplantation (auto-HCT) for relapsed/refractory (R/R) T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) has never been specifically investigated. Here, we have…

Younger unrelated donors may be preferable over HLA match in the PTCy era: a study from the ALWP of the EBMT Open

Jaime Sanz, Myriam Labopin, Goda Choi, Alexander Kulagin, Jacopo Peccatori , et al. · 2024

There is a paucity of information on how to select the most appropriate unrelated donor (UD) in hematopoietic stem cell transplantation (HSCT) using posttransplant cyclophosphamide (PTCy). We retrospectively analyzed the characteristics of…

Endothelial Activation and Stress Index (EASIX) to predict mortality after allogeneic stem cell transplantation: a prospective study Open

Olaf Penack, Thomas Luft, Christophe Peczynski, Axel Benner, Simona Sica , et al. · 2024

Background We previously reported that the “Endothelial Activation and Stress Index” (EASIX; ((creatinine×lactate dehydrogenase)÷thrombocytes)) measured before start of conditioning predicts mortality after allogeneic hematopoietic stem ce…

Engineering of CD34+ progenitor-derived natural killer cells with higher-affinity CD16a for enhanced antibody-dependent cellular cytotoxicity Open

P.M.M. van Hauten, Laura Hooijmaijers, Marcos Vidal-Manrique, Anniek B. van der Waart, Willemijn Hobo , et al. · 2023

Together, these data demonstrate that the applicability of adoptive NK cell immunotherapy may be broadened to less NK-sensitive malignancies by upregulation of CD16a expression in combination with the use of tumor-targeting monoclonal anti…

Early liver complications after allogeneic haematopoietic stem cell transplantation in patients with myelofibrosis: A study on behalf of the Chronic Malignancies Working Party of the <span>EBMT</span> Open

Marie Robin, Luuk Gras, Linda Köster, Nico Gagelmann, Gwendolyn Van Gorkom , et al. · 2023

Contains fulltext : 303475.pdf (Publisher’s version ) (Open Access)

Human CD34+-derived complete plasmacytoid and conventional dendritic cell vaccine effectively induces antigen-specific CD8+ T cell and NK cell responses in vitro and in vivo Open

Jesper van Eck van der Sluijs, Diede van Ens, Jolanda Brummelman, Daan Heister, Aastha Sareen , et al. · 2023

Allogeneic hematopoietic cell transplantation in patients with CALR-mutated myelofibrosis: a study of the Chronic Malignancies Working Party of EBMT Open

Juan Carlos Hernández‐Boluda, Diderik-Jan Eikema, Linda Köster, Nicolaus Kröger, Marie Robin , et al. · 2023

Etoposide plus cytarabine versus cyclophosphamide or melphalan in busulfan-based preparative regimens for autologous stem cell transplantation in adults with acute myeloid leukemia in first complete remission: a study from the Acute Leukemia Working Party of the EBMT Open

Jaime Sanz, Myriam Labopin, Thomas Pabst, Jurjen Versluis, Gwendolyn Van Gorkom , et al. · 2023

Carfilzomib, lenalidomide and dexamethasone followed by a second ASCT is an effective strategy in first relapse multiple myeloma: a study on behalf of the Chronic malignancies working party of the EBMT Open

Rémi Tilmont, Ibrahim Yakoub‐Agha, Diderik-Jan Eikema, Nienke Zinger, Mathias Haenel , et al. · 2023

In the setting of a first relapse of multiple myeloma (MM), a second autologous stem cell transplant (ASCT) following carfilzomib-lenalidomide-dexamethasone (KRd) is an option, although there is scarce data concerning this approach. We per…

S249: SELECTIVE JAK2/IRAK1/ACVR1 INHIBITOR PACRITINIB BEFORE REDUCED-INTENSITY CONDITIONING ALLOGENEIC STEM CELL TRANSPLANTATION IN MYELOFIBROSIS: FINAL ANALYSIS OF THE PHASE II HOVON-134 TRIAL Open

Ruben Van Dijck, Bronno van der Holt, Ellen Meijer, Timothy Devos, Mette D. Hazenberg , et al. · 2023

Background: Allogeneic stem cell transplantation (alloSCT) remains the only curative treatment option for patients with myelofibrosis (MF). The selective JAK2/IRAK1/ACVR1 inhibitor pacritinib (PAC) is effective in reducing spleen size and …

Good manufacturing practice production of CD34+ progenitor-derived NK cells for adoptive immunotherapy in acute myeloid leukemia Open

Paul K.J.D. de Jonge, P.M.M. van Hauten, L. D. Janssen, Anna L. de Goede, Melissa M. Berrien-Elliott , et al. · 2023

Allogeneic Stem Cell Transplantation in Patients >40 Years of Age With Acute Lymphoblastic Leukemia: Reduced Intensity Versus Myeloablative Conditioning Open

Anikó Sijs‐Szabó, Avinash G. Dinmohamed, Jurjen Versluis, Bronno van der Holt, Mar Bellido , et al. · 2023

Background. The outcome in older patients with acute lymphoblastic leukemia (ALL) remains unsatisfactory due to high relapse and nonrelapse mortality (NRM) rates. Allogeneic stem cell transplantation (alloHSCT) as postremission therapy has…

Allogeneic hematopoietic cell transplantation in patients with CALR-mutated myelofibrosis: a study of the Chronic Malignancies Working Party of EBMT Open

Juan Carlos Hernández‐Boluda, Diderik-Jan Eikema, Linda Köster, Nicolaus Kroeger, Marie Robin , et al. · 2023

Allogeneic hematopoietic cell transplantation (allo-HCT) is curative for myelofibrosis (MF) but assessing risk-benefit in individual patients is challenging. This complexity is amplified in CALR- mutated MF patients, as they live longer wi…

Correction: An early post-transplant relapse prediction score in multiple myeloma: a large cohort study from the chronic malignancies working party of EBMT Open

Meral Beksaç, Simona Iacobelli, Linda Köster, Jan J. Cornelissen, Laimonas Griškevičius , et al. · 2023

Etoposide plus cytarabine versus cyclophosphamide or melphalan in busulfan-based preparative regimens for autologous stem cell transplantation in adults with acute myeloid leukemia in first complete remission: A study from the Acute Leukemia Working Party of the EBMT Open

Myriam Labopin, Thomas Pabst, Jurjen Versluis, Gwendolyn Van Gorkom, Ellen Meijer , et al. · 2023

Introduction High-dose myeloablative chemotherapy followed by autologous stem cell transplantation (ASCT) is a valid treatment option for patients with acute myeloid leukemia (AML) in first complete remission (CR1). However, information on…

Autologous hematopoietic cell transplantation (autoHCT) for T‐cell/histiocyte‐rich large B‐cell lymphoma (THRLBCL): An EBMT Lymphoma Working Party study Open

S. Renders, H Finel, Maud Ngoya, Ariane Boumendil, Nicolaas Schaap , et al. · 2023

Introduction: THRLBCL is an orphan entity of large B-cell lymphomas (LBCL). It is dominated by stromal and immune components—especially T-cells and histiocytes—with similarities to nodular lymphocyte-predominant Hodgkin lymphoma. This micr…

Supplementary Figure 2 from PD-1/PD-L1 Interactions Contribute to Functional T-Cell Impairment in Patients Who Relapse with Cancer After Allogeneic Stem Cell Transplantation Open