Anne Moore
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View article: Cross-Border Differences in Public Knowledge, Awareness, Behaviours and Beliefs related to Antibiotics and Antimicrobial Resistance across the island of Ireland
Cross-Border Differences in Public Knowledge, Awareness, Behaviours and Beliefs related to Antibiotics and Antimicrobial Resistance across the island of Ireland Open
Background Antimicrobial resistance (AMR) is predicted to be liable for 10 million annual deaths worldwide by 2050, driven significantly by public cognitions and behaviours. Given the frequent social and economic interactions between peopl…
View article: Systematic mapping review of preclinical and clinical studies of Staphylococcus aureus vaccines
Systematic mapping review of preclinical and clinical studies of Staphylococcus aureus vaccines Open
Staphylococcus aureus is a pathogen that annually causes more than one million deaths globally. However, despite substantial research, no vaccine for human use has yet been licensed. We conducted a systematic mapping review to evaluate the…
View article: A Scoping Review of Factors Affecting COVID-19 Vaccination Uptake and Deployment in Global Healthcare Systems
A Scoping Review of Factors Affecting COVID-19 Vaccination Uptake and Deployment in Global Healthcare Systems Open
Introduction: COVID-19 vaccines were rapidly developed and deployed on a large scale during a global crisis. A range of deployment strategies were used globally to maximize vaccine uptake. In this scoping review, we identify and analyze th…
View article: Elimination of Human Papillomavirus 16-Positive Tumors by a Mucosal rAd5 Therapeutic Vaccination in a Pre-Clinical Murine Study
Elimination of Human Papillomavirus 16-Positive Tumors by a Mucosal rAd5 Therapeutic Vaccination in a Pre-Clinical Murine Study Open
Therapeutic vaccination can harness the body’s cellular immune system to target and destroy cancerous cells. Several treatment options are available to eliminate pre-cancerous and cancerous lesions caused by human papillomaviruses (HPV), b…
View article: A Synthesis of Agricultural Literacy Research Between 2011 and 2022
A Synthesis of Agricultural Literacy Research Between 2011 and 2022 Open
In 2013, Kovar and Ball published a literature review on the agricultural literacy research conducted from 1988 to 2011. As a result of their study, they located 49 articles published in that time frame. Since then, agricultural literacy r…
View article: Elimination of human papillomavirus 16-induced tumors by a mucosal rAd5 therapeutic vaccination in a pre-clinical study
Elimination of human papillomavirus 16-induced tumors by a mucosal rAd5 therapeutic vaccination in a pre-clinical study Open
Therapeutic vaccination can harness the body’s cellular immune system to target and destroy cancerous cells. Several invasive treatments are currently used to eliminate cancerous lesions caused by human papillomaviruses (HPV), however ther…
View article: Lack of influence of social media on vaccine decision-making by university students in Ireland
Lack of influence of social media on vaccine decision-making by university students in Ireland Open
Vaccine hesitancy is a complex, context-specific issue that negatively impacts vaccine uptake. During the COVID-19 pandemic, vaccine mis- and dis-information on social media negatively impacted on COVID-19 vaccine acceptance. University st…
View article: DATASET Skin-Based Vaccination: A Systematic Mapping Review of the Types of Vaccines and Methods Used and Immunity and Protection Elicited in Pigs
DATASET Skin-Based Vaccination: A Systematic Mapping Review of the Types of Vaccines and Methods Used and Immunity and Protection Elicited in Pigs Open
Dataset listing all publications used in systematic mapping review. This file contains the dataset, a dictionary and values worksheets for the following publication: Skin-Based Vaccination: A Systematic Mapping Review of the Types of Vacci…
View article: DATASET Skin-Based Vaccination: A Systematic Mapping Review of the Types of Vaccines and Methods Used and Immunity and Protection Elicited in Pigs
DATASET Skin-Based Vaccination: A Systematic Mapping Review of the Types of Vaccines and Methods Used and Immunity and Protection Elicited in Pigs Open
Dataset listing all publications used in systematic mapping review. This file contains the dataset, a dictionary and values worksheets for the following publication: Skin-Based Vaccination: A Systematic Mapping Review of the Types of Vacci…
View article: The impact of fingolimod on Treg function in brain ischaemia
The impact of fingolimod on Treg function in brain ischaemia Open
Fingolimod has generally shown neuroprotective effects in stroke models. Here, we tested the hypothesis that fingolimod modulates T‐cell cytokine production towards a regulatory phenotype. Second, we investigated how fingolimod altered the…
View article: Supplementary Figure S2 from Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases
Supplementary Figure S2 from Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases Open
This figure shows that the amount of time to achieve first Cp {less than or equal to} 17 mg/dL was significantly reduced for TN compared to non-TN patients.
View article: Supplementary Figure S2 from Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases
Supplementary Figure S2 from Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases Open
This figure shows that the amount of time to achieve first Cp {less than or equal to} 17 mg/dL was significantly reduced for TN compared to non-TN patients.
View article: Supplementary Statistical Methods from Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases
Supplementary Statistical Methods from Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases Open
This section contains details of all mixed models utilized in the statistical analyses. The inferential tests performed in this paper necessitates a multiple comparisons adjustment, and details of the adjustment procedure is included in th…
View article: Supplementary Table 2 from Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases
Supplementary Table 2 from Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases Open
This is the demographics table containing detailed baseline patient characteristics listed for each of the 75 patients. The data is de-identified.
View article: Supplementary Figure S3 from Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases
Supplementary Figure S3 from Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases Open
The top panel shows the reaction chemistry of established lysyl oxidase (LOX) activity assay. The bottom panel shows the Amplex Red/HRP-based LOX activity assay that detects LOX activity in vitro.
View article: Supplementary Table 1 from Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases
Supplementary Table 1 from Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases Open
This is the demographics table containing brief summary of baseline patient characteristics of patients enrolled on trial.
View article: Data from Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases
Data from Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases Open
Purpose: Bone marrow–derived progenitor cells, including VEGFR2+ endothelial progenitor cells (EPCs) and copper-dependent pathways, model the tumor microenvironment. We hypothesized that copper depletion using tetrathiomolybdate would redu…
View article: Supplementary Statistical Methods from Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases
Supplementary Statistical Methods from Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases Open
This section contains details of all mixed models utilized in the statistical analyses. The inferential tests performed in this paper necessitates a multiple comparisons adjustment, and details of the adjustment procedure is included in th…
View article: Supplementary Table 2 from Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases
Supplementary Table 2 from Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases Open
This is the demographics table containing detailed baseline patient characteristics listed for each of the 75 patients. The data is de-identified.
View article: Supplementary Figure S1 from Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases
Supplementary Figure S1 from Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases Open
This is the schema of the clinical study design. This is a Phase 2 trial of TM in breast cancer at high risk of recurrence. Eligible patients received TM for 2 years to achieve a target CP level of < 17 mg/dL. Primary endpoint was effect o…
View article: Supplementary Figure S3 from Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases
Supplementary Figure S3 from Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases Open
The top panel shows the reaction chemistry of established lysyl oxidase (LOX) activity assay. The bottom panel shows the Amplex Red/HRP-based LOX activity assay that detects LOX activity in vitro.
View article: Data from Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases
Data from Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases Open
Purpose: Bone marrow–derived progenitor cells, including VEGFR2+ endothelial progenitor cells (EPCs) and copper-dependent pathways, model the tumor microenvironment. We hypothesized that copper depletion using tetrathiomolybdate would redu…
View article: Supplementary Table 1 from Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases
Supplementary Table 1 from Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases Open
This is the demographics table containing brief summary of baseline patient characteristics of patients enrolled on trial.
View article: Supplementary Figure S1 from Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases
Supplementary Figure S1 from Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases Open
This is the schema of the clinical study design. This is a Phase 2 trial of TM in breast cancer at high risk of recurrence. Eligible patients received TM for 2 years to achieve a target CP level of < 17 mg/dL. Primary endpoint was effect o…
View article: Skin-Based Vaccination: A Systematic Mapping Review of the Types of Vaccines and Methods Used and Immunity and Protection Elicited in Pigs
Skin-Based Vaccination: A Systematic Mapping Review of the Types of Vaccines and Methods Used and Immunity and Protection Elicited in Pigs Open
The advantages of skin-based vaccination include induction of strong immunity, dose-sparing, and ease of administration. Several technologies for skin-based immunisation in humans are being developed to maximise these key advantages. This …
View article: Identifying intervention strategies to improve HPV vaccine decision-making using behaviour change theory
Identifying intervention strategies to improve HPV vaccine decision-making using behaviour change theory Open
Although the HPV vaccine is highly safe and effective, its uptake is sub-optimal in many countries, including Ireland. There is therefore a need to identify appropriate interventions that will increase HPV vaccine acceptance by parents. In…
View article: Recombinant pregnancy-specific glycoprotein-1-Fc reduces functional deficit in a mouse model of permanent brain ischaemia
Recombinant pregnancy-specific glycoprotein-1-Fc reduces functional deficit in a mouse model of permanent brain ischaemia Open
The administration of rPSG1-Fc improved functional recovery in post-ischaemic mice without impacting infarct size. Improved outcome was associated with a modulation of the cytokine-secreting phenotype of CD4+ and CD8+ T cells towards a mor…
View article: Preclinical Evaluation of Fingolimod in Rodent Models of Stroke With Age or Atherosclerosis as Comorbidities
Preclinical Evaluation of Fingolimod in Rodent Models of Stroke With Age or Atherosclerosis as Comorbidities Open
Preclinical data indicate that fingolimod improves outcome post-ischaemia. This study used a rigorous study design in normal male C57BL/6JOlaHsd mice and in mice with common stroke comorbidities to further evaluate the translational potent…
View article: A Video-Based Behavioral Intervention Associated with Improved HPV Knowledge and Intention to Vaccinate
A Video-Based Behavioral Intervention Associated with Improved HPV Knowledge and Intention to Vaccinate Open
The aim of this study was to design, develop, and evaluate the feasibility of a theory- and evidence-based intervention to improve human papillomavirus (HPV) and HPV vaccine knowledge and intention to vaccinate, among parent–daughter dyads…
View article: Trends in drug- and vaccine-based dissolvable microneedle materials and methods of fabrication
Trends in drug- and vaccine-based dissolvable microneedle materials and methods of fabrication Open
Microneedlepatches, also called microarray patches(MAP),are an emergingtechnology for deliveryand samplingof drugs, vaccines and other materials. This review focuses on the materials and methods used to fabricate dissolvable microneedles(D…