Barbara A. Murphy
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View article: Influence of Extended Photoperiod Using Blue Light Masks on Hypertrichosis, Coat Condition and General Health Parameters in Horses with Pituitary Pars Intermedia Dysfunction
Influence of Extended Photoperiod Using Blue Light Masks on Hypertrichosis, Coat Condition and General Health Parameters in Horses with Pituitary Pars Intermedia Dysfunction Open
Fifty-two horses aged >15 years, diagnosed with pituitary pars intermedia dysfunction (PPID), and displaying hypertrichosis were recruited via an online survey of PPID horse owners. From mid-December, group T (n = 29) wore Equilume® light …
View article: Using the galactose‐α‐1,3‐galactose enzyme‐linked immunosorbent assay to predict anaphylaxis in response to cetuximab
Using the galactose‐α‐1,3‐galactose enzyme‐linked immunosorbent assay to predict anaphylaxis in response to cetuximab Open
BACKGROUND: Cetuximab is a monoclonal antibody against epidermal growth factor receptor with activity against head and neck cancer and colorectal cancer. Anaphylaxis in response to cetuximab is a significant clinical problem in the Southea…
View article: Charting the equine miRNA landscape: An integrated pipeline and browser for annotating, quantifying, and visualizing expression
Charting the equine miRNA landscape: An integrated pipeline and browser for annotating, quantifying, and visualizing expression Open
MicroRNAs (miRNAs) are essential regulators of gene expression, yet few comprehensive databases exist for miRNA expression in non-model species, limiting our ability to characterize their roles in gene regulation, development, and disease.…
View article: Cetuximab Hypersensitivity in the Setting of Asymptomatic Alpha‐Gal Sensitization
Cetuximab Hypersensitivity in the Setting of Asymptomatic Alpha‐Gal Sensitization Open
Background Alpha‐gal syndrome is an allergic condition resulting from the bite of the Lonestar tick in the southeastern US that leads to sensitization to mammalian products containing the oligosaccharide galactose‐alpha‐1,3‐galactose (alph…
View article: Influence of Extended Photoperiod Using Blue Light Masks on Hypertrichosis, Coat Condition and General Health Parameters in Horses with Pituitary Pars Intermedia Dysfunction
Influence of Extended Photoperiod Using Blue Light Masks on Hypertrichosis, Coat Condition and General Health Parameters in Horses with Pituitary Pars Intermedia Dysfunction Open
Fifty-two horses aged >15 years, diagnosed with pituitary pars intermedia dysfunction (PPID), and displaying hypertrichosis were recruited via an online survey of PPID horse owners. From mid-December, group T wore Equilume® light masks …
View article: Feasibility and preliminary efficacy of a lymphedema and fibrosis self-management program for head and neck cancer survivors: a pilot randomized controlled trial
Feasibility and preliminary efficacy of a lymphedema and fibrosis self-management program for head and neck cancer survivors: a pilot randomized controlled trial Open
gov/study/NCT03030859.
View article: Influence of lighting on sleep behaviour, circadian rhythm and spontaneous blink rate in stabled riding school horses (Equus caballus)
Influence of lighting on sleep behaviour, circadian rhythm and spontaneous blink rate in stabled riding school horses (Equus caballus) Open
Modern horse husbandry involves significant time spent indoors, often in suboptimal lighting conditions and with frequent night-time disturbances by humans for management purposes. The aim of this study was to investigate the influence of …
View article: Tenascin-C Potentiates Wnt Signaling in Thyroid Cancer
Tenascin-C Potentiates Wnt Signaling in Thyroid Cancer Open
Tenascin-C (TNC) is a secreted extracellular matrix protein that is highly expressed during embryonic development and re-expressed during wound healing, inflammation, and neoplasia. Studies in developmental models suggest that TNC may regu…
View article: Climate change impact on blood haemogram in the horse: a three-year preliminary study
Climate change impact on blood haemogram in the horse: a three-year preliminary study Open
Introduction The global climatic changes pose a substantial threat to the well-being and productivity of both humans and animals. Methods This study examined the impact of climate changes during different seasons over a 3-year monitoring p…
View article: Tenascin-C potentiates Wnt signaling in thyroid cancer
Tenascin-C potentiates Wnt signaling in thyroid cancer Open
Tenascin-C (TNC) is a secreted extracellular matrix protein that is highly expressed during embryonic development and re-expressed during wound healing, inflammation, and neoplasia. Studies in developmental models suggest that TNC may regu…
View article: Evaluation of short-term hair follicle storage conditions for maintenance of RNA integrity
Evaluation of short-term hair follicle storage conditions for maintenance of RNA integrity Open
Hair follicles provide an easily accessible tissue for interrogating gene expression for multiple purposes in mammals. RNAlater® is a liquid storage solution that stabilises and preserves cellular RNA, eliminating the need to immediately p…
View article: Qualitative Classification of Late Systemic Symptoms in Head and Neck Cancer Survivors
Qualitative Classification of Late Systemic Symptoms in Head and Neck Cancer Survivors Open
Improved rates of cancer control have increased the head and neck cancer survivor population. Cancer survivorship clinics are not widely available in the USA, and longitudinal supportive care for patients undergoing multimodal therapy has …
View article: Equine Headshaking Syndrome: Triggers, Seasonality, and Treatment Efficacy in Australia
Equine Headshaking Syndrome: Triggers, Seasonality, and Treatment Efficacy in Australia Open
Equine headshaking syndrome is a poorly understood neuropathic pain condition presenting as uncontrollable shaking, flicking, or striking of the head. Therapeutic options are limited, and treatments are only partially successful. Currently…
View article: One Health: Circadian Medicine Benefits Both Non-human Animals and Humans Alike
One Health: Circadian Medicine Benefits Both Non-human Animals and Humans Alike Open
Circadian biology’s impact on human physical health and its role in disease development and progression is widely recognized. The forefront of circadian rhythm research now focuses on translational applications to clinical medicine, aiming…
View article: Sclerosing odontogenic carcinoma presenting in the maxilla of a 64-year-old female: A case report
Sclerosing odontogenic carcinoma presenting in the maxilla of a 64-year-old female: A case report Open
Sclerosing odontogenic carcinoma (SOC) is a rare intraosseous carcinoma of the jaw which was recently added to the World Health Organization classification of head and neck tumors. We report a case of SOC in the left maxilla of a 64-year-o…
View article: Exploring the Relations among Psychological Flexibility, Music Performance Anxiety, and Perceived Performance Quality with University Music Students
Exploring the Relations among Psychological Flexibility, Music Performance Anxiety, and Perceived Performance Quality with University Music Students Open
Acceptance and commitment therapy (ACT) is a “third wave” behavioral therapy that aims to increase psychological flexibility through mindfulness, acceptance, and behavioral commitment processes. This study explored relations among facets o…
View article: Evaluation of short-term hair follicle storage conditions for maintenance of RNA integrity
Evaluation of short-term hair follicle storage conditions for maintenance of RNA integrity Open
Hair follicles provide an easily accessible tissue for interrogating gene expression in mammals. RNAlater® is a liquid storage solution that stabilises and preserves cellular RNA, eliminating the need to immediately process or freeze tissu…
View article: Neurocognitive Impairment in Non-Central Nervous System Cancer Survivors
Neurocognitive Impairment in Non-Central Nervous System Cancer Survivors Open
Cancer and its treatments entail a profound inflammatory response of the central nervous system (CNS). This intense neurotoxic process can lead to significant neurocognitive impairment even in non-CNS cancers. Few studies have examined thi…
View article: Increased microglia activation in late non‐central nervous system cancer survivors links to chronic systemic symptomatology
Increased microglia activation in late non‐central nervous system cancer survivors links to chronic systemic symptomatology Open
Prolonged inflammatory expression within the central nervous system (CNS) is recognized by the brain as a molecular signal of “sickness”, that has knock‐on effects to the blood–brain barrier, brain‐spinal barrier, blood‐cerebrospinal fluid…
View article: Molecular signature incorporating the immune microenvironment enhances thyroid cancer outcome prediction
Molecular signature incorporating the immune microenvironment enhances thyroid cancer outcome prediction Open
Genomic and transcriptomic analysis has furthered our understanding of many tumors. Yet, thyroid cancer management is largely guided by staging and histology, with few molecular prognostic and treatment biomarkers. Here, we utilize a large…
View article: Optimised Stable Lighting Strengthens Circadian Clock Gene Rhythmicity in Equine Hair Follicles
Optimised Stable Lighting Strengthens Circadian Clock Gene Rhythmicity in Equine Hair Follicles Open
Hair follicles (HF) represent a useful tissue for monitoring the circadian clock in mammals. Irregular light exposure causes circadian disruption and represents a welfare concern for stabled horses. We aimed to evaluate the impact of two s…
View article: Data from Phase II Efficacy and Pharmacogenomic Study of Selumetinib (AZD6244; ARRY-142886) in Iodine-131 Refractory Papillary Thyroid Carcinoma with or without Follicular Elements
Data from Phase II Efficacy and Pharmacogenomic Study of Selumetinib (AZD6244; ARRY-142886) in Iodine-131 Refractory Papillary Thyroid Carcinoma with or without Follicular Elements Open
Purpose: A multicenter, open-label, phase II trial was conducted to evaluate the efficacy, safety, and tolerability of selumetinib in iodine-refractory papillary thyroid cancer (IRPTC).Experimental Design: Patients with advanced IRPTC with…
View article: CCR Translation for This Article from Phase II Efficacy and Pharmacogenomic Study of Selumetinib (AZD6244; ARRY-142886) in Iodine-131 Refractory Papillary Thyroid Carcinoma with or without Follicular Elements
CCR Translation for This Article from Phase II Efficacy and Pharmacogenomic Study of Selumetinib (AZD6244; ARRY-142886) in Iodine-131 Refractory Papillary Thyroid Carcinoma with or without Follicular Elements Open
CCR Translation for This Article from Phase II Efficacy and Pharmacogenomic Study of Selumetinib (AZD6244; ARRY-142886) in Iodine-131 Refractory Papillary Thyroid Carcinoma with or without Follicular Elements
View article: Supplementary Tables 1-4 from Detection of Tumor Epidermal Growth Factor Receptor Pathway Dependence by Serum Mass Spectrometry in Cancer Patients
Supplementary Tables 1-4 from Detection of Tumor Epidermal Growth Factor Receptor Pathway Dependence by Serum Mass Spectrometry in Cancer Patients Open
Supplementary Tables 1-4 from Detection of Tumor Epidermal Growth Factor Receptor Pathway Dependence by Serum Mass Spectrometry in Cancer Patients
View article: Data from Phase II Efficacy and Pharmacogenomic Study of Selumetinib (AZD6244; ARRY-142886) in Iodine-131 Refractory Papillary Thyroid Carcinoma with or without Follicular Elements
Data from Phase II Efficacy and Pharmacogenomic Study of Selumetinib (AZD6244; ARRY-142886) in Iodine-131 Refractory Papillary Thyroid Carcinoma with or without Follicular Elements Open
Purpose: A multicenter, open-label, phase II trial was conducted to evaluate the efficacy, safety, and tolerability of selumetinib in iodine-refractory papillary thyroid cancer (IRPTC).Experimental Design: Patients with advanced IRPTC with…
View article: Supplementary Tables 1-4 from Detection of Tumor Epidermal Growth Factor Receptor Pathway Dependence by Serum Mass Spectrometry in Cancer Patients
Supplementary Tables 1-4 from Detection of Tumor Epidermal Growth Factor Receptor Pathway Dependence by Serum Mass Spectrometry in Cancer Patients Open
Supplementary Tables 1-4 from Detection of Tumor Epidermal Growth Factor Receptor Pathway Dependence by Serum Mass Spectrometry in Cancer Patients
View article: CCR Translation for This Article from Phase II Efficacy and Pharmacogenomic Study of Selumetinib (AZD6244; ARRY-142886) in Iodine-131 Refractory Papillary Thyroid Carcinoma with or without Follicular Elements
CCR Translation for This Article from Phase II Efficacy and Pharmacogenomic Study of Selumetinib (AZD6244; ARRY-142886) in Iodine-131 Refractory Papillary Thyroid Carcinoma with or without Follicular Elements Open
CCR Translation for This Article from Phase II Efficacy and Pharmacogenomic Study of Selumetinib (AZD6244; ARRY-142886) in Iodine-131 Refractory Papillary Thyroid Carcinoma with or without Follicular Elements
View article: Data from Detection of Tumor Epidermal Growth Factor Receptor Pathway Dependence by Serum Mass Spectrometry in Cancer Patients
Data from Detection of Tumor Epidermal Growth Factor Receptor Pathway Dependence by Serum Mass Spectrometry in Cancer Patients Open
Background: We hypothesized that a serum proteomic profile predictive of survival benefit in non–small cell lung cancer patients treated with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) reflects tumor EGFR depend…
View article: Data from Detection of Tumor Epidermal Growth Factor Receptor Pathway Dependence by Serum Mass Spectrometry in Cancer Patients
Data from Detection of Tumor Epidermal Growth Factor Receptor Pathway Dependence by Serum Mass Spectrometry in Cancer Patients Open
Background: We hypothesized that a serum proteomic profile predictive of survival benefit in non–small cell lung cancer patients treated with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) reflects tumor EGFR depend…