Christophe Chambon
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View article: Biochemical characterization of the Escherichia coli surfaceome: a focus on type I fimbriae and flagella
Biochemical characterization of the Escherichia coli surfaceome: a focus on type I fimbriae and flagella Open
The Escherichia coli surfaceome consists mainly of the large surface organelles expressed by the organism to navigate and interact with the surrounding environment. The current study focuses on type I fimbriae and flagella. These large pol…
View article: Fermented food consumption modulates the oral microbiota
Fermented food consumption modulates the oral microbiota Open
Fermented food consumption is recommended for health and environmental purposes. While it is known to impact gut microbiota, further investigation is needed to establish connections with the oral microbiota. For this purpose, we investigat…
View article: Peptidomics analysis of in vitro digested wheat breads: Effect of genotype and environment on protein digestibility and release of celiac disease and wheat allergy related epitopes
Peptidomics analysis of in vitro digested wheat breads: Effect of genotype and environment on protein digestibility and release of celiac disease and wheat allergy related epitopes Open
Wheat proteins can trigger immunogenic reactions due to their resistance to digestion and immunostimulatory epitopes. Here, we investigated the peptidomic map of partially digested bread samples and the fingerprint of epitope diversity fro…
View article: Biochemical characterization of the<i>Escherichia coli</i>surfaceome: A focus on type I fimbriae and flagella
Biochemical characterization of the<i>Escherichia coli</i>surfaceome: A focus on type I fimbriae and flagella Open
The Escherichia coli surfaceome consists mainly of the large surface organelles expressed by the organism to navigate and interact with the surrounding environment. The current study focuses on type I fimbriae and flagella. These large pol…
View article: Meat-based functional foods - Variability of the glycation reaction in gelatin
Meat-based functional foods - Variability of the glycation reaction in gelatin Open
International audience
View article: A multi-centre peptidomics investigation of food digesta: current state of the art in mass spectrometry analysis and data visualisation
A multi-centre peptidomics investigation of food digesta: current state of the art in mass spectrometry analysis and data visualisation Open
Mass spectrometry has become the technique of choice for the assessment of a high variety of molecules in complex food matrices. It is best suited for monitoring the evolution of digestive processes in vivo and in vitro. However, consideri…
View article: Characterization of the Skeletal Muscle Proteome in Undernourished Old Rats
Characterization of the Skeletal Muscle Proteome in Undernourished Old Rats Open
Aging is associated with a progressive loss of skeletal muscle mass and function termed sarcopenia. Various metabolic alterations that occur with aging also increase the risk of undernutrition, which can worsen age-related sarcopenia. Howe…
View article: A Single Bout of Ultra-Endurance Exercise Reveals Early Signs of Muscle Aging in Master Athletes
A Single Bout of Ultra-Endurance Exercise Reveals Early Signs of Muscle Aging in Master Athletes Open
Middle-aged and master endurance athletes exhibit similar physical performance and long-term muscle adaptation to aerobic exercise. Nevertheless, we hypothesized that the short-term plasticity of the skeletal muscle might be distinctly alt…
View article: Impact of Tannin Supplementation on Proteolysis during Post-Ruminal Digestion in Wethers Using a Dynamic <i>In Vitro</i> System: A Plant (<i>Medicago sativa</i>) Digestomic Approach
Impact of Tannin Supplementation on Proteolysis during Post-Ruminal Digestion in Wethers Using a Dynamic <i>In Vitro</i> System: A Plant (<i>Medicago sativa</i>) Digestomic Approach Open
The aim of this study was to characterize the effects of tannins on plant protein during sheep digestion using a digestomic approach combining in vivo (rumen) conditions and an in vitro digestive system (abomasum and small intestine). Rumi…
View article: Understanding the Effects of a Tannin Extract on Forage Protein Understanding the Effects of a Tannin Extract on Forage Protein
Understanding the Effects of a Tannin Extract on Forage Protein Understanding the Effects of a Tannin Extract on Forage Protein Open
International audience
View article: Detection of Frozen–Thawed Duck Fatty Liver by MALDI-TOF Mass Spectrometry: A Chemometrics Study
Detection of Frozen–Thawed Duck Fatty Liver by MALDI-TOF Mass Spectrometry: A Chemometrics Study Open
The marketing of poultry livers is only authorized as fresh, frozen, or deep-frozen. The higher consumer demand for these products for a short period of time may lead to the marketing of frozen–thawed poultry livers: this constitutes fraud…
View article: Investigation by Synchrotron Radiation Circular Dichroism of the Secondary Structure Evolution of Pepsin under Oxidative Environment
Investigation by Synchrotron Radiation Circular Dichroism of the Secondary Structure Evolution of Pepsin under Oxidative Environment Open
Food processing affects the structure and chemical state of proteins. In particular, protein oxidation occurs and may impair protein properties. These chemical reactions initiated during processing can develop during digestion. Indeed, the…
View article: Muscle Proteomic and Transcriptomic Profiling of Healthy Aging and Metabolic Syndrome in Men
Muscle Proteomic and Transcriptomic Profiling of Healthy Aging and Metabolic Syndrome in Men Open
(1) Background: Aging is associated with a progressive decline in muscle mass and function. Aging is also a primary risk factor for metabolic syndrome, which further alters muscle metabolism. However, the molecular mechanisms involved rema…
View article: Deciphering the protein digestion of meat products for the elderly by <i>in vitro</i> food oral processing and gastric dynamic digestion, peptidome analysis and modeling
Deciphering the protein digestion of meat products for the elderly by <i>in vitro</i> food oral processing and gastric dynamic digestion, peptidome analysis and modeling Open
FODP: Food Oral and Digestive Processing.
View article: Prediction of the Secretome and the Surfaceome: A Strategy to Decipher the Crosstalk between Adipose Tissue and Muscle during Fetal Growth
Prediction of the Secretome and the Surfaceome: A Strategy to Decipher the Crosstalk between Adipose Tissue and Muscle during Fetal Growth Open
Crosstalk between adipose and muscular tissues is hypothesized to regulate the number of muscular and adipose cells during fetal growth, with post-natal consequences on lean and fat masses. Such crosstalk largely remains, however, to be de…
View article: Toward the Prediction of the PSE-Like Muscle Defect in Cooked Hams
Toward the Prediction of the PSE-Like Muscle Defect in Cooked Hams Open
Pale Soft Exudative (PSE)-like muscle defect is of great importance in the cooked ham industry because of the economic losses it can cause. The flagship product is the “Jambon supérieur,” a polyphosphate-free cooked ham, usually sold slice…
View article: Next-Generation Sequencing and MALDI Mass Spectrometry in the Study of Multiresistant Processed Meat Vancomycin-Resistant Enterococci (VRE)
Next-Generation Sequencing and MALDI Mass Spectrometry in the Study of Multiresistant Processed Meat Vancomycin-Resistant Enterococci (VRE) Open
Vancomycin-resistant enterococci (VRE), due to their intrinsic resistance to various commonly used antibiotics and their malleable genome, make the treatment of infections caused by these bacteria less effective. The aims of this work were…
View article: Putative Protein Biomarkers of Escherichia coli Antibiotic Multiresistance Identified by MALDI Mass Spectrometry
Putative Protein Biomarkers of Escherichia coli Antibiotic Multiresistance Identified by MALDI Mass Spectrometry Open
The commensal bacteria Escherichia coli causes several intestinal and extra-intestinal diseases, since it has virulence factors that interfere in important cellular processes. These bacteria also have a great capacity to spread the resista…
View article: DOP49 Quantitative proteomics analysis of macrophages from Crohn’s disease patients and infected with adherent-invasive Escherichia coli
DOP49 Quantitative proteomics analysis of macrophages from Crohn’s disease patients and infected with adherent-invasive Escherichia coli Open
Background Crohn’s disease (CD) is a disabling inflammatory bowel disease. Currently, the available treatments only alleviate the symptoms. The anti-TNFα represent the most efficient therapeutic class, but its mechanisms are poorly known. …
View article: Proteomic analysis of mature kernel aleurone layer of Triticum spelta and three wheat related species
Proteomic analysis of mature kernel aleurone layer of Triticum spelta and three wheat related species Open
Introduction. The peripheral layers (PL) of wheat, including the aleurone layer (AL), are an important source of micronutrients. AL is excluded, and mainly used for animal feed, although these tissues have significant nutritional potential…
View article: Listeria monocytogenes Biofilm Adaptation to Different Temperatures Seen Through Shotgun Proteomics
Listeria monocytogenes Biofilm Adaptation to Different Temperatures Seen Through Shotgun Proteomics Open
Listeria monocytogenes is a foodborne pathogen that can cause invasive severe human illness (listeriosis) in susceptible patients. Most human listeriosis cases appear to be caused by consumption of refrigerated ready-to-eat foods. Although…
View article: Mammary Gland Transcriptome and Proteome Modifications by Nutrient Restriction in Early Lactation Holstein Cows Challenged with Intra-Mammary Lipopolysaccharide
Mammary Gland Transcriptome and Proteome Modifications by Nutrient Restriction in Early Lactation Holstein Cows Challenged with Intra-Mammary Lipopolysaccharide Open
The objective is to study the effects of nutrient restrictions, which induce a metabolic imbalance on the inflammatory response of the mammary gland in early lactation cows. The aim is to decipher the molecular mechanisms involved, by comp…
View article: Mammary gland transcriptome and proteome modifications by nutrient restriction in early lactation Holstein cows challenged with intramammary lipopolysaccharide
Mammary gland transcriptome and proteome modifications by nutrient restriction in early lactation Holstein cows challenged with intramammary lipopolysaccharide Open
The objective is to study the effects of nutrient restrictions, which induce a metabolic imbalance on the inflammatory response of the mammary gland in early lactation cows. The aim is to decipher the molecular mechanisms involved, by comp…
View article: Increased Serpina3n release into circulation during glucocorticoid‐mediated muscle atrophy
Increased Serpina3n release into circulation during glucocorticoid‐mediated muscle atrophy Open
Background Glucocorticoids (GC) play a major role in muscle atrophy. As skeletal muscle is a secretory organ, characterization of the muscle secretome elicited by muscle atrophy should allow to better understand the cellular mechanisms and…