Christopher Patterson
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View article: Periodontitis and future cognitive decline
Periodontitis and future cognitive decline Open
Background Periodontitis (gum disease) is a is a chronic inflammatory disorder. Porphyromonas gingivalis (Pg), Tannerella forsythia (Tf), Aggregatibacter actinomyecetemcomitans (Aa), and Treponema denticola (Td) are the most common periodo…
View article: Hand grip strength, anthropometrics and cognitive decline
Hand grip strength, anthropometrics and cognitive decline Open
Background Hand grip strength is a well validated measure of physical strength, while anthropometric measures such as weight, waist, hip and mid upper arm circumference, are well validated to determine physical health. The present analysis…
View article: Albuminuria-Related Genetic Biomarkers: Replication and Predictive Evaluation in Individuals with and without Diabetes from the UK Biobank
Albuminuria-Related Genetic Biomarkers: Replication and Predictive Evaluation in Individuals with and without Diabetes from the UK Biobank Open
Increased albuminuria indicates underlying glomerular pathology and is associated with worse renal disease outcomes, especially in diabetic kidney disease. Many single nucleotide polymorphisms (SNPs), associated with albuminuria, could be …
View article: The Incidence Trend of Type 1 Diabetes among Children and Adolescents 0-14 Years of Age in the West, South, and Tripoli Regions of Libya (2009-2018)
The Incidence Trend of Type 1 Diabetes among Children and Adolescents 0-14 Years of Age in the West, South, and Tripoli Regions of Libya (2009-2018) Open
The incidence of T1D in Libyan children in the West, South, and Tripoli regions appears to be rising, with a higher rate in the 0-4 and 5-9 year age groups.
View article: Cancer incidence and mortality in 23 000 patients with type 1 diabetes in the UK: Long‐term follow‐up
Cancer incidence and mortality in 23 000 patients with type 1 diabetes in the UK: Long‐term follow‐up Open
Type 2 diabetes is associated with raised risk of several cancers, but for type 1 diabetes risk data are fewer and inconsistent We assembled a cohort of 23 473 UK patients with insulin‐treated diabetes diagnosed at ages <30, almost all of …
View article: Subgingival microbial diversity and respiratory decline: A cross‐sectional study
Subgingival microbial diversity and respiratory decline: A cross‐sectional study Open
Aim To investigate whether there is an association between subgingival microbial diversity and reduced respiratory function. Materials and Methods A group of dentate 58–72‐year‐old men in Northern Ireland had a comprehensive periodontal ex…
View article: Exposure to gun violence among the population of Chicago community violence interventionists
Exposure to gun violence among the population of Chicago community violence interventionists Open
Gun violence is a leading cause of premature death and a driver of racial disparities in life expectancy in the United States. Community-based interventions are the foremost policy strategy for reducing gun violence without exacerbating ha…
View article: Association of TGFB1 rs1800469 and BCMO1 rs6564851 with coronary heart disease and IL1B rs16944 with all-cause mortality in men from the Northern Ireland PRIME study
Association of TGFB1 rs1800469 and BCMO1 rs6564851 with coronary heart disease and IL1B rs16944 with all-cause mortality in men from the Northern Ireland PRIME study Open
Background Historically, high levels of morbidity and mortality have been associated with cardiovascular disease in the Northern Ireland population. Previously reported associations between single nucleotide polymorphisms (SNPs) and cardio…
View article: Online Educational Tools for Caregivers of People with Dementia: A Scoping Literature Review
Online Educational Tools for Caregivers of People with Dementia: A Scoping Literature Review Open
Background Informal caregivers of people with dementia provide the majority of health-based care to people with dementia. Providing this care requires knowledge and access to resources, which caregivers often do not receive. We set out to …
View article: Trial to Encourage Adoption and Maintenance of a MEditerranean Diet (TEAM-MED): a randomised pilot trial of a peer support intervention for dietary behaviour change in adults from a Northern European population at high CVD risk
Trial to Encourage Adoption and Maintenance of a MEditerranean Diet (TEAM-MED): a randomised pilot trial of a peer support intervention for dietary behaviour change in adults from a Northern European population at high CVD risk Open
Adhering to a Mediterranean diet (MD) is associated with reduced CVD risk. This study aimed to explore methods of increasing MD adoption in a non-Mediterranean population at high risk of CVD, including assessing the feasibility of a develo…
View article: Frailty differences across population characteristics associated with health inequality: a cross-sectional analysis of baseline data from the Canadian Longitudinal Study on Aging (CLSA)
Frailty differences across population characteristics associated with health inequality: a cross-sectional analysis of baseline data from the Canadian Longitudinal Study on Aging (CLSA) Open
Objective To evaluate the pattern of frailty across several of social stratifiers associated with health inequalities. Design, setting and participants Cross-sectional baseline data on 51 338 community-living women and men aged 45–85 years…
View article: Systemic inflammation and the relationship between periodontitis, edentulism, and all‐cause mortality: A 17‐year prospective cohort study
Systemic inflammation and the relationship between periodontitis, edentulism, and all‐cause mortality: A 17‐year prospective cohort study Open
Aim The aim was to investigate the role of systemic inflammation in the relationship between periodontitis, edentulism, and all‐cause mortality in a group of men in Northern Ireland aged 58–72 years. Materials and methods A representative …
View article: Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients Attending the Diabetic Clinic of the University of Gondar Hospital, Northwest Ethiopia
Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients Attending the Diabetic Clinic of the University of Gondar Hospital, Northwest Ethiopia Open
Objective. To investigate the level of diabetic retinopathy in type 2 diabetes (T2DM) patients attending the University of Gondar Hospital (UGH) Diabetic Clinic, Northwest Ethiopia. Methods. An audit was carried out involving a total of 73…
View article: Canadian Indigenous Cognitive Assessment (CICA): Inter‐rater reliability and criterion validity in Anishinaabe communities on Manitoulin Island, Canada
Canadian Indigenous Cognitive Assessment (CICA): Inter‐rater reliability and criterion validity in Anishinaabe communities on Manitoulin Island, Canada Open
Introduction Despite increasing dementia rates, few culturally informed cognitive assessment tools exist for Indigenous populations. The Canadian Indigenous Cognitive Assessment (CICA) was adapted with First Nations on Manitoulin Island, C…
View article: Additional file 2 of A globally diverse reference alignment and panel for imputation of mitochondrial DNA variants
Additional file 2 of A globally diverse reference alignment and panel for imputation of mitochondrial DNA variants Open
Additional file 2. Supplementary tables. Includes sequence IDs, geographic provenance data, haplogroup assignment summaries, and statistical test results.
View article: Implementation of a multicomponent intervention sign to reduce delirium in orthopaedic inpatients (MIND-ORIENT): a quality improvement project
Implementation of a multicomponent intervention sign to reduce delirium in orthopaedic inpatients (MIND-ORIENT): a quality improvement project Open
Delirium is a serious and common condition that leads to significant adverse health outcomes for hospitalised older adults. It occurs in 30%–55% of patients with hip fractures and is one of the most common postoperative complications in ol…
View article: Adaptation of the Canadian indigenous cognitive assessment in three provinces and evidence for validity
Adaptation of the Canadian indigenous cognitive assessment in three provinces and evidence for validity Open
Background The Canadian Indigenous Cognitive Assessment (CICA) tool is an innovative culturally‐grounded dementia case finding tool. Currently, dementia is underdiagnosed and when diagnosis occurs it is at later stages in Indigenous popula…
View article: Adherence to a Mediterranean diet is associated with better cognitive performance many years later in the PRIME cohort
Adherence to a Mediterranean diet is associated with better cognitive performance many years later in the PRIME cohort Open
Background Greater adherence to a Mediterranean Diet (MD) has been associated with reduced cognitive decline and dementia risk. The Prospective Epidemiological Study of Myocardial Infarction (PRIME) recruited 10,600 European male participa…
View article: Changes in glycated hemoglobin, diabetes knowledge, quality of life, and anxiety in children and adolescents with type 1 diabetes attending summer camps: A systematic review and meta‐analysis
Changes in glycated hemoglobin, diabetes knowledge, quality of life, and anxiety in children and adolescents with type 1 diabetes attending summer camps: A systematic review and meta‐analysis Open
Diabetes summer camps provide children and adolescents with type 1 diabetes opportunities to learn about the disease and its management in a supportive environment to help improve glycemic control, self-reliance, and quality of life. The o…
View article: DNA Methylation Associated With Diabetic Kidney Disease in Blood-Derived DNA
DNA Methylation Associated With Diabetic Kidney Disease in Blood-Derived DNA Open
A subset of individuals with type 1 diabetes will develop diabetic kidney disease (DKD). DKD is heritable and large-scale genome-wide association studies have begun to identify genetic factors that influence DKD. Complementary to genetic f…
View article: Periodontitis and risk of prevalent and incident coronary heart disease events
Periodontitis and risk of prevalent and incident coronary heart disease events Open
Objective To investigate periodontitis as a risk factor for prevalent and incident coronary heart disease (CHD) in a group of middle‐aged men from Northern Ireland. Methods A representative sample of 1400 dentate men had a comprehensive pe…