Anne Rosser
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View article: Antidopaminergic Medications Are Associated with Faster Decline in Measures of Clinical Outcome in HD: Insights from PROOF-HD
Antidopaminergic Medications Are Associated with Faster Decline in Measures of Clinical Outcome in HD: Insights from PROOF-HD Open
Background Antidopaminergic medications (ADMs), including vesicular monoamine transporter-2 (VMAT2) inhibitors and antipsychotics, are frequently-used to manage Huntington disease (HD) symptoms. Prior studies suggest that ADMs may be assoc…
View article: In vivo mapping of striatal neurodegeneration in Huntington’s disease with Soma and Neurite Density Imaging
In vivo mapping of striatal neurodegeneration in Huntington’s disease with Soma and Neurite Density Imaging Open
Background Huntington’s Disease (HD) is an inherited neurodegenerative disorder characterised by progressive cognitive and motor decline due to atrophy in basal ganglia networks. No disease-modifying therapies exist, but novel clinical tri…
View article: Author response: In vivo mapping of striatal neurodegeneration in Huntington’s disease with Soma and Neurite Density Imaging
Author response: In vivo mapping of striatal neurodegeneration in Huntington’s disease with Soma and Neurite Density Imaging Open
View article: In vivo mapping of striatal neurodegeneration in Huntington’s disease with Soma and Neurite Density Imaging
In vivo mapping of striatal neurodegeneration in Huntington’s disease with Soma and Neurite Density Imaging Open
Background Huntington’s Disease (HD) is an inherited neurodegenerative disorder characterised by progressive cognitive and motor decline due to atrophy in basal ganglia networks. No disease-modifying therapies exist, but novel clinical tri…
View article: Pridopidine in early-stage manifest Huntington’s disease: a phase 3 trial
Pridopidine in early-stage manifest Huntington’s disease: a phase 3 trial Open
Huntington’s disease (HD) is a rare, neurodegenerative disorder for which only symptomatic treatments are available. The PROOF-HD study was a randomized, double-blind, placebo-controlled phase 3 trial evaluating the efficacy and safety of …
View article: Antidepressant Treatment in Huntington’s Disease: Regional and Case-Control Variation
Antidepressant Treatment in Huntington’s Disease: Regional and Case-Control Variation Open
Objectives Determine differences in frequency and choice of antidepressant for anxiety and depression between pwHD and controls. Determine if regional variation affects antidepressant prescribing between pwHD and controls. Methods We used …
View article: The phase 3 PROOF-HD trial demonstrates persistent benefits of pridopidine on function, cognition, and motor function through the 6 month open label extension in Huntington disease (HD)
The phase 3 PROOF-HD trial demonstrates persistent benefits of pridopidine on function, cognition, and motor function through the 6 month open label extension in Huntington disease (HD) Open
View article: Complex cognitive and motivational deficits precede motor dysfunction in the zQ175 (190 CAG repeat) Huntington's disease model
Complex cognitive and motivational deficits precede motor dysfunction in the zQ175 (190 CAG repeat) Huntington's disease model Open
Huntington's disease (HD) is a progressive, inherited neurodegenerative disorder characterised by motor, cognitive, and neuropsychiatric dysfunction for which several mouse models have been developed. Knock-in models, such as zQ175, retain…
View article: The TransEuro open-label trial of human fetal ventral mesencephalic transplantation in patients with moderate Parkinson’s disease
The TransEuro open-label trial of human fetal ventral mesencephalic transplantation in patients with moderate Parkinson’s disease Open
Transplantation of human fetal ventral mesencephalic tissue in individuals with Parkinson’s disease has yielded clinical benefits but also side effects, such as graft-induced dyskinesias. The open-label TransEuro trial ( NCT01898390 ) was …
View article: Imaging of human stem cell-derived dopamine grafts correlates with behavioural recovery and reveals microstructural brain changes
Imaging of human stem cell-derived dopamine grafts correlates with behavioural recovery and reveals microstructural brain changes Open
View article: Antidepressants and Slower Disease Progression in Huntington’s Disease
Antidepressants and Slower Disease Progression in Huntington’s Disease Open
Importance Antidepressants are the most frequently prescribed medication in Huntington’s disease; this study examines the effect of antidepressants on disease progression. Objectives Determine the effects on disease progression (composite …
View article: In vivo mapping of striatal neurodegeneration in Huntington’s disease with Soma and Neurite Density Imaging
In vivo mapping of striatal neurodegeneration in Huntington’s disease with Soma and Neurite Density Imaging Open
Background Huntington’s Disease (HD) is an inherited neurodegenerative disorder characterised by progressive cognitive and motor decline due to atrophy in basal ganglia networks. No disease-modifying therapies exist, but novel clinical tri…
View article: Graft ischemia post cell transplantation to the brain: Glucose deprivation as the primary driver of rapid cell death
Graft ischemia post cell transplantation to the brain: Glucose deprivation as the primary driver of rapid cell death Open
View article: The joint memory effect: challenging the selfish stigma in Huntington’s disease?
The joint memory effect: challenging the selfish stigma in Huntington’s disease? Open
The prevalent belief that individuals with Huntington’s disease exhibit selfish behaviour, disregarding the thoughts, feelings and actions of others, has been challenged by patient organizations and clinical experts. To further investigate…
View article: Huntington’s disease phenocopy syndromes revisited: a clinical comparison and next-generation sequencing exploration
Huntington’s disease phenocopy syndromes revisited: a clinical comparison and next-generation sequencing exploration Open
Background Genetic testing for Huntington’s disease (HD) was initially usually positive but more recently the negative rate has increased: patients with negative HD tests are described as having HD phenocopy syndromes (HDPC). This study ex…
View article: Refining the Language of Huntington’s Disease Progression with the Huntington’s Disease Integrated Staging System (HD-ISS)
Refining the Language of Huntington’s Disease Progression with the Huntington’s Disease Integrated Staging System (HD-ISS) Open
View article: Protocol for a randomised controlled unblinded feasibility trial of HD-DRUM: a rhythmic movement training application for cognitive and motor symptoms in people with Huntington’s disease
Protocol for a randomised controlled unblinded feasibility trial of HD-DRUM: a rhythmic movement training application for cognitive and motor symptoms in people with Huntington’s disease Open
Introduction Huntington’s disease (HD) is an inherited neurodegenerative disease causing progressive cognitive and motor decline, largely due to basal ganglia (BG) atrophy. Rhythmic training offers promise as therapy to counteract BG-regul…
View article: Defining the Limits of hPSC Derived Models: hPSC-MSNs Fail to Recapitulate Authentic Striatal Identity
Defining the Limits of hPSC Derived Models: hPSC-MSNs Fail to Recapitulate Authentic Striatal Identity Open
Human pluripotent stem cells (hPSCs) are increasingly used to model human disease and as donor cells for regenerative medicine. However, the fidelity of hPSC-derived cell types remains a major concern, particularly when these cells are int…
View article: Language-Independent Acoustic Biomarkers for Quantifying Speech Impairment in Huntington's Disease
Language-Independent Acoustic Biomarkers for Quantifying Speech Impairment in Huntington's Disease Open
Purpose: Changes in voice and speech are characteristic symptoms of Huntington's disease (HD). Objective methods for quantifying speech impairment that can be used across languages could facilitate assessment of disease progression and int…
View article: An Overview of Specialist Services for Huntington’s Disease in the United Kingdom
An Overview of Specialist Services for Huntington’s Disease in the United Kingdom Open
Background: Huntington’s disease (HD) is a rare inherited neurodegenerative disorder characterized by complex evolving needs that change as the condition progresses. There is limited understanding about the organization of HD clinical serv…
View article: An Overview of Specialist Services for Huntington’s Disease in the United Kingdom
An Overview of Specialist Services for Huntington’s Disease in the United Kingdom Open
Background: Huntington’s disease (HD) is a rare inherited neurodegenerative disorder characterized by complex evolving needs that change as the condition progresses. There is limited understanding about the organization of HD clinical serv…
View article: Protocol for a randomised controlled feasibility trial of HD-DRUM, a rhythmic movement training application for cognitive and motor symptoms in people with Huntington’s disease
Protocol for a randomised controlled feasibility trial of HD-DRUM, a rhythmic movement training application for cognitive and motor symptoms in people with Huntington’s disease Open
Introduction Huntington’s disease (HD) is an inherited neurodegenerative disease causing progressive cognitive and motor decline, largely due to basal ganglia (BG) atrophy. Rhythmic training offers promise as therapy to counteract BG-regul…
View article: Differences in white matter detected by<i>ex vivo</i>9.4T MRI are associated with axonal changes in the R6/1 model of Huntington’s Disease
Differences in white matter detected by<i>ex vivo</i>9.4T MRI are associated with axonal changes in the R6/1 model of Huntington’s Disease Open
White matter (WM) volume loss has been reported in people with Huntington’s disease (HD), but the cellular basis of this deficit remains to be elucidated. To address this, we assessed ex vivo WM microstructure in the transgenic R6/1 mouse …
View article: HD-DRUM, a Tablet-Based Drumming Training App Intervention for People With Huntington Disease: App Development Study
HD-DRUM, a Tablet-Based Drumming Training App Intervention for People With Huntington Disease: App Development Study Open
Background Huntington disease (HD) is a neurodegenerative condition that leads to progressive loss of cognitive-executive and motor functions, largely due to basal ganglia (BG) atrophy. Currently, there are no therapeutic interventions tai…
View article: Identification of the Neural Correlates Underlying Conflict Resolution Performance Using a Rodent Analogue of the Stroop Tests
Identification of the Neural Correlates Underlying Conflict Resolution Performance Using a Rodent Analogue of the Stroop Tests Open
The Stroop test is a widely used neuropsychological test measuring attention and conflict resolution, which shows sensitivity across a range of diseases, including Alzheimer's, Parkinson's and Huntington's diseases. A rodent analogue of th…
View article: Single-Cell Transcriptomics Reveals Conserved Regulatory Networks in Human and Mouse Interneuron Development
Single-Cell Transcriptomics Reveals Conserved Regulatory Networks in Human and Mouse Interneuron Development Open
Inhibitory GABAergic interneurons originate in the embryonic medial ganglionic eminence (MGE) and control network activity in the neocortex. Dysfunction of these cells is believed to lead to runaway excitation underlying seizure-based neur…
View article: HD-DRUM, a Tablet-Based Drumming Training App Intervention for People With Huntington Disease: App Development Study (Preprint)
HD-DRUM, a Tablet-Based Drumming Training App Intervention for People With Huntington Disease: App Development Study (Preprint) Open
BACKGROUND Huntington disease (HD) is a neurodegenerative condition that leads to progressive loss of cognitive-executive and motor functions, largely due to basal ganglia (BG) atrophy. Currently, there are no therapeutic interventions ta…
View article: A new approach to digitized cognitive monitoring: validity of the SelfCog in Huntington’s disease
A new approach to digitized cognitive monitoring: validity of the SelfCog in Huntington’s disease Open
Cognitive deficits represent a hallmark of neurodegenerative diseases, but evaluating their progression is complex. Most current evaluations involve lengthy paper-and-pencil tasks which are subject to learning effects dependent on the mode…
View article: Excessive response to provocation rather than disinhibition mediates irritable behaviour in Huntington’s disease
Excessive response to provocation rather than disinhibition mediates irritable behaviour in Huntington’s disease Open
Background Irritable and impulsive behaviour are common in Huntington’s disease (HD: an autosomal dominant disorder causing degeneration in cortico-striatal networks). However, the cognitive mechanisms underlying these symptoms remain uncl…
View article: The striatum in time production: The model of Huntington's disease in longitudinal study
The striatum in time production: The model of Huntington's disease in longitudinal study Open
The unified model of time processing suggests that the striatum is a central structure involved in all tasks that require the processing of temporal durations. Patients with Huntington's disease exhibit striatal degeneration and a deficit …