Explanipedia

Ovarian reserve markers in women of reproductive ages with epilepsy Open

Clara Colombo, Janne Gasseholm Bentzen, Michael Oettinger, Henriette Ewers, Lars H. Pinborg , et al. · 2025

Overall, women with epilepsy did not have diminished ovarian reserve as age-adjusted markers of ovarian reserve (AMH and AFC levels) were comparable to a control group of women without epilepsy. In daily clinical practice, this provides re…

Programming in Vagus nerve stimulation therapy: Consensus from a Nordic Delphi Panel Open

Oliver Henning, Noémi Becser Andersen, Fredrik Asztély, Elinor Ben‐Menachem, Helena Gauffin , et al. · 2025

The recommendations of the Delphi panel emphasize proactive deployment of available stimulation options including build up in duty cycle and the use of rapid cycling as well as increasing the output current if response with primary target …

Cognitive outcomes after fetal exposure to carbamazepine, lamotrigine, valproate or levetiracetam monotherapy: Data from the EURAP neurocognitive extension protocol Open

Susanna Stjerna, Yfke Huber‐Mollema, Torbjörn Tomson, Emilio Perucca, Dina Battino , et al. · 2024

Consistent with previous reports, our results provide evidence for an adverse effect of prenatal exposure to valproate on verbal development. Our finding of relatively weaker performance of VPA-exposed children compared to other ASM exposu…

Potentially avoidable mortality among adults with intellectual disability Open

Lau Caspar Thygesen, Marie Borring Klitgaard, Anne Sabers, Jakob Kjellberg, Jens Søndergaard , et al. · 2024

Persons with intellectual disabilities (ID) face pronounced health disparities. The aim of this study was to describe premature mortality by causes of death and avoidable mortality among persons with ID compared to the general Danish popul…

Risk of Major Congenital Malformations and Exposure to Antiseizure Medication Monotherapy Open

Dina Battino, Torbjörn Tomson, Erminio Bonizzoni, John Craig, Emilio Perucca , et al. · 2024

Importance Women with epilepsy (WWE) require treatment with antiseizure medications (ASMs) during pregnancy, which may be associated with an increased risk of major congenital malformations (MCMs) in their offspring. Objective To investiga…

The phenotypic presentation of adult individuals with SLC6A1-related neurodevelopmental disorders Open

Katrine M. Johannesen, Jimmi Nielsen, Anne Sabers, Bertrand Isidor, Anja A. Kattentidt‐Mouravieva , et al. · 2023

Introduction SLC6A1 is one of the most common monogenic causes of epilepsy and is a well-established cause of neurodevelopmental disorders. SLC6A1 -neurodevelopmental disorders have a consistent phenotype of mild to severe intellectual dis…

Local networks from different parts of the human cerebral cortex generate and share the same population dynamic Open

Alex Willumsen, Jens Midtgaard, Bo Jespersen, Christoffer K.K. Hansen, Salina N. Lam , et al. · 2022

A major goal of neuroscience is to reveal mechanisms supporting collaborative actions of neurons in local and larger-scale networks. However, no clear overall principle of operation has emerged despite decades-long experimental efforts. He…

Feasibility of transcutaneous auricular vagus nerve stimulation in treatment of drug resistant epilepsy: A multicenter prospective study Open

Anne Sabers, Sophia Aumüller-Wagner, Lars Rune Christensen, Oliver Henning, Konstantin Hrisimirov Kostov , et al. · 2021

Table of Contents Open

Yin-Hsuan Lai, Yu‐Chen Huang, Liang‐Ti Huang, Ming Chen, Chen , et al. · 2020

Declining malformation rates with changed antiepileptic drug prescribing Open

Torbjörn Tomson, Dina Battino, Erminio Bonizzoni, John Craig, Dick Lindhout , et al. · 2019

There have been major changes in AED prescription patterns over the years covered by the study. In parallel, we observed a significant 27% decrease in the prevalence of MCMs. The results of adjusting the trend analysis for MCMs for changes…

Electromagnetic source imaging in presurgical workup of patients with epilepsy Open

Lene Duez, Hatice Tankişi, Peter Orm Hansen, Per Sidenius, Anne Sabers , et al. · 2019

This study provides Class IV evidence that EMSI had a concordance of 53%-89% and 35%-73% (depending on analysis) for the localization of epileptic focus as compared with intracranial recordings-IZ and SOZ, respectively.

EURAP registry: inadequate monitoring of prescribed drugs in pregnancy – Authors' reply Open

Torbjörn Tomson, Dina Battino, Erminio Bonizzoni, John Craig, Dick Lindhout , et al. · 2018

Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry Open

Torbjörn Tomson, Dina Battino, Erminio Bonizzoni, John Craig, Dick Lindhout , et al. · 2018

Does vagus nerve stimulation influence pregnancy outcomes? Open

Anne Sabers, L. Buchgreitz, Winfried Neuhuber · 2017

An Account of how Attention to Usability and Lifestyle Issues may Contribute to Protocols for Clinical Trials of Medical Devices (Preprint) Open

Lars Rune Christensen, Lene Nielsen, Anne Sabers · 2017

UNSTRUCTURED Objectives: Within the field of medicine attempts have been made to establish the efficacy of new treatments with medical devises by double blind randomized clinical trials. Very precise protocols have been developed for this…

Do we have to include HCI issues in clinical trials of medical devices? Open

Lene Nielsen, Lars Rune Christensen, Anne Sabers · 2017

Digital devices play an important role in medical treatment and will in the future play a larger role in connection to cures of health-related issues.
Traditionally medicine has been tested by clinical double blind, randomized trials …

Welfare consequences for people with epilepsy and their partners: A matched nationwide study in Denmark Open

Poul Jennum, Anne Sabers, Jakob Christensen, Rikke Ibsen, Jakob Kjellberg · 2017

A prospective observational longitudinal study of new-onset seizures and newly diagnosed epilepsy in dogs Open

N. Fredsø, Nils Toft, Anne Sabers, Mette Berendt · 2016

Socioeconomic evaluation of vagus stimulation: A controlled national study Open

Poul Jennum, Anne Sabers, Jakob Christensen, Rikke Ibsen, Jakob Kjellberg · 2016

Quantitative Electroencephalography as a Diagnostic Tool for Alzheimer's Dementia in Adults with Down Syndrome Open

Lise Cronberg Salem, Anne Sabers, Troels W. Kjær, Christian Sandøe Musaeus, Martin N. Nielsen , et al. · 2015

Background: Assessment of dementia in individuals with intellectual disability is complex due to great inter-individual variability in cognitive function prior to dementia and a lack of standardized instruments. Studies have …

Antiepileptic drugs and intrauterine death Open

Torbjörn Tomson, Dina Battino, Erminio Bonizzoni, John Craig, Dick Lindhout , et al. · 2015

The most important risk factors for intrauterine death in pregnancies of women with epilepsy include maternal exposure to AED polytherapy and the presence of MCMs in at least one of the parents.

Dose-dependent teratogenicity of valproate in mono- and polytherapy Open

Torbjörn Tomson, Dina Battino, Erminio Bonizzoni, John Craig, Dick Lindhout , et al. · 2015

The risk of MCMs associated with VPA exposure increases with increasing VPA dose, both in the presence and in the absence of one concomitant AED, and appears to be related primarily to the dose of VPA.

Interactions between hormonal contraception and antiepileptic drugs: Clinical and mechanistic considerations Open

Arne Reimers, Eylert Brodtkorb, Anne Sabers · 2015

Anne Sabers YOU? Author Swipe