Anneke Miedema
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View article: Microglia endotoxin tolerance is retained after enforced repopulation
Microglia endotoxin tolerance is retained after enforced repopulation Open
Microglia are crucial for CNS homeostasis and are involved in a wide range of neurodegenerative and neuroinflammatory diseases. Systemic inflammation and infections can contribute to neurodegeneration later in life by affecting microglia. …
View article: Spatially resolved gene signatures of white matter lesion progression in multiple sclerosis
Spatially resolved gene signatures of white matter lesion progression in multiple sclerosis Open
View article: Identification of regional astrocyte heterogeneity associated with cuprizone-induced de- and remyelination using spatial transcriptomics
Identification of regional astrocyte heterogeneity associated with cuprizone-induced de- and remyelination using spatial transcriptomics Open
The cuprizone model is a well-characterized model to study processes of demyelination and remyelination, which are known features of multiple sclerosis. Cuprizone induces oligodendrocyte loss and severe demyelination in the brain, includin…
View article: Thiosulfate sulfurtransferase deficiency promotes oxidative distress and aberrant NRF2 function in the brain
Thiosulfate sulfurtransferase deficiency promotes oxidative distress and aberrant NRF2 function in the brain Open
Thiosulfate sulfurtransferase (TST, EC 2.8.1.1) was discovered as an enzyme that detoxifies cyanide by conversion to thiocyanate (rhodanide) using thiosulfate as substrate; this rhodanese activity was subsequently identified to be almost e…
View article: Mosaic of glia in multiple sclerosis
Mosaic of glia in multiple sclerosis Open
Multiple sclerosis (ms) is a common disease of the central nervous system (cns), characterized by chronic inflammation, demyelination and neuronal damage. Different lesion types develop within the cns of ms patients in both gray and white …
View article: Thiosulfate Sulfurtransferase Deficiency Promotes Oxidative Distress and Aberrant NRF2 Function in the Brain
Thiosulfate Sulfurtransferase Deficiency Promotes Oxidative Distress and Aberrant NRF2 Function in the Brain Open
View article: Transcriptomic changes in autophagy-related genes are inversely correlated with inflammation and are associated with multiple sclerosis lesion pathology
Transcriptomic changes in autophagy-related genes are inversely correlated with inflammation and are associated with multiple sclerosis lesion pathology Open
Autophagy is a lysosomal degradative pathway essential for maintaining cellular homeostasis and is also implicated in multiple aspects of both innate and adaptive immunity. Neuroinflammation, along with demyelination and axonal loss, is an…
View article: Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter
Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter Open
Multiple sclerosis (MS) is a disease of the central nervous system that is characterized by inflammation and focal areas of demyelination, ultimately resulting in axonal degradation and neuronal loss. Several lines of evidence point toward…
View article: Additional file 6 of Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter
Additional file 6 of Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter Open
Additional file 6: Table S1: Donor and sample information. Table S2: Differential gene expression analysis total tissue bulk data. Table S3: WGCNA modules. Table S4: Differential gene expression analysis between clusters (human single cell…
View article: Brain macrophages acquire distinct transcriptomes prior to demyelination in multiple sclerosis
Brain macrophages acquire distinct transcriptomes prior to demyelination in multiple sclerosis Open
Multiple sclerosis (MS) is a disease of the central nervous system (CNS) that is characterized by inflammation and focal areas of demyelination, ultimately resulting in axonal degradation and neuronal loss. Several lines of evidence point …
View article: Circulating tumor DNA as a biomarker for monitoring early treatment responses of patients with advanced lung adenocarcinoma receiving immune checkpoint inhibitors
Circulating tumor DNA as a biomarker for monitoring early treatment responses of patients with advanced lung adenocarcinoma receiving immune checkpoint inhibitors Open
Immunotherapy for metastasized non‐small‐cell lung cancer (NSCLC) can show long‐lasting clinical responses. Selection of patients based on programmed death‐ligand 1 (PD‐L1) expression shows limited predictive value for durable clinical ben…
View article: Author response for "Circulating tumor DNA as a biomarker for monitoring early treatment responses of patients with advanced lung adenocarcinoma receiving immune checkpoint inhibitors"
Author response for "Circulating tumor DNA as a biomarker for monitoring early treatment responses of patients with advanced lung adenocarcinoma receiving immune checkpoint inhibitors" Open
View article: Author response for "Circulating tumor DNA as a biomarker for monitoring early treatment responses of patients with advanced lung adenocarcinoma receiving immune checkpoint inhibitors"
Author response for "Circulating tumor DNA as a biomarker for monitoring early treatment responses of patients with advanced lung adenocarcinoma receiving immune checkpoint inhibitors" Open
View article: Profiling Microglia From Alzheimer’s Disease Donors and Non-demented Elderly in Acute Human Postmortem Cortical Tissue
Profiling Microglia From Alzheimer’s Disease Donors and Non-demented Elderly in Acute Human Postmortem Cortical Tissue Open
Microglia are the tissue-resident macrophages of the central nervous system (CNS). Recent studies based on bulk and single-cell RNA sequencing in mice indicate high relevance of microglia with respect to risk genes and neuro-inflammation i…
View article: High-Resolution Transcriptomic and Proteomic Profiling of Heterogeneity of Brain-Derived Microglia in Multiple Sclerosis
High-Resolution Transcriptomic and Proteomic Profiling of Heterogeneity of Brain-Derived Microglia in Multiple Sclerosis Open
Microglia are important for central nervous system (CNS) homeostasis and first to respond to tissue damage and perturbations. Microglia are heterogeneous cells; in case of pathology, microglia adopt a range of phenotypes with altered funct…
View article: Comparison of Circulating Cell-Free DNA Extraction Methods for Downstream Analysis in Cancer Patients
Comparison of Circulating Cell-Free DNA Extraction Methods for Downstream Analysis in Cancer Patients Open
Circulating cell-free DNA (ccfDNA) may contain DNA originating from the tumor in plasma of cancer patients (ctDNA) and enables noninvasive cancer diagnosis, treatment predictive testing, and response monitoring. A recent multicenter evalua…
View article: Profiling microglia from AD donors and non-demented elderly in acute human post-mortem cortical tissue
Profiling microglia from AD donors and non-demented elderly in acute human post-mortem cortical tissue Open
Microglia are the tissue-resident macrophages of the central nervous system (CNS). Recent studies based on bulk and single-cell RNA sequencing in mice indicate high relevance of microglia with respect to risk genes and neuro-inflammation i…