Annelise Genoux
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View article: ApoJ and apoL1 as novel determinants of MASH: a cross-sectional study
ApoJ and apoL1 as novel determinants of MASH: a cross-sectional study Open
Background Plasma apolipoproteins are linked to cardiometabolic dysfunctions, but their potential as biomarkers for metabolic dysfunction-associated steatohepatitis (MASH) remains underexplored. Methods Plasma levels of 14 apolipoproteins …
View article: ApoL1 and ApoJ as Novel Determinants of MASH: A cross-sectional study
ApoL1 and ApoJ as Novel Determinants of MASH: A cross-sectional study Open
Background Plasma apolipoproteins are linked to cardiometabolic dysfunctions, but their potential as biomarkers for metabolic dysfunction-associated steatohepatitis (MASH) remains underexplored. Methods Plasma levels of 14 apolipoproteins …
View article: Plasma apolipoprotein concentrations and occurrence of cardiovascular events in the general population: an exploratory analysis
Plasma apolipoprotein concentrations and occurrence of cardiovascular events in the general population: an exploratory analysis Open
This study identifies a novel panel of apolipoproteins (A-I, A-IV, C-I, D, H, and J) whose levels are associated with occurrence of cardiovascular diseases, independently of traditional risk factors. Further research is needed to confirm t…
View article: Associations between physical activity levels and ATPase inhibitory factor 1 concentrations in older adults
Associations between physical activity levels and ATPase inhibitory factor 1 concentrations in older adults Open
This study demonstrates that regular PA is associated with plasma IF1 concentrations, and it suggests that apoA-I partly mediates this association. Additionally, this study finds that baseline concentrations of IF1 can predict future chang…
View article: Plasma level of ATPase inhibitory factor 1 (IF1) is associated with type 2 diabetes risk in humans: A prospective cohort study
Plasma level of ATPase inhibitory factor 1 (IF1) is associated with type 2 diabetes risk in humans: A prospective cohort study Open
We identified for the first time the mitochondrial-related biomarker IF1 as being associated with the risk of T2DM.
View article: Plasma level of ATPase inhibitory factor 1 (IF1) is associated with type 2 diabetes risk in humans: a prospective cohort study
Plasma level of ATPase inhibitory factor 1 (IF1) is associated with type 2 diabetes risk in humans: a prospective cohort study Open
Aim: Mitochondrial dysfunction is associated with the development of type 2 diabetes (T2D). It is thus of clinical relevance to identify plasma biomarkers of mitochondrial dysfunction associated with the risk of T2D.ATPase inhibitory facto…
View article: Plasma level of ATPase inhibitory factor 1 (IF1) is associated with type 2 diabetes risk in humans: a prospective cohort study
Plasma level of ATPase inhibitory factor 1 (IF1) is associated with type 2 diabetes risk in humans: a prospective cohort study Open
Background: Mitochondrial dysfunction is associated with the development of type 2 diabetes (T2D). It is thus of clinical relevance to identify plasma biomarkers of mitochondrial dysfunction associated with the risk of T2D.ATPase inhibitor…
View article: The Multifaceted ATPase Inhibitory Factor 1 (IF1) in Energy Metabolism Reprogramming and Mitochondrial Dysfunction: A New Player in Age-Associated Disorders?
The Multifaceted ATPase Inhibitory Factor 1 (IF1) in Energy Metabolism Reprogramming and Mitochondrial Dysfunction: A New Player in Age-Associated Disorders? Open
Significance: The mitochondrial oxidative phosphorylation (OXPHOS) system, comprising the electron transport chain and ATP synthase, generates membrane potential, drives ATP synthesis, governs energy metabolism, and maintains redox balance…
View article: Update on proprotein convertase subtilisin/kexin type 9 inhibitors, lipoprotein(a) and cardiovascular risk
Update on proprotein convertase subtilisin/kexin type 9 inhibitors, lipoprotein(a) and cardiovascular risk Open
International audience
View article: Is it time to reconcile HDL with cardiovascular diseases and beyond? An update on a paradigm shift
Is it time to reconcile HDL with cardiovascular diseases and beyond? An update on a paradigm shift Open
International audience
View article: Effects of leptin and adiponectin on the cardiovascular system
Effects of leptin and adiponectin on the cardiovascular system Open
Elevated circulating leptin levels have been associated with an increased cardiovascular risk in humans. However, recent meta-analyses show that certain epidemiological studies did not find this association, suggesting distinct effects of …
View article: Mutltifaceted biological roles of adiponectin
Mutltifaceted biological roles of adiponectin Open
Adiponectin is a major adipokine involved in energy homeostasis that exerts insulin-sensitizing properties. The level of adiponectin is reduced in situations of insulin resistance and is negatively associated with several pathophysiologica…
View article: Mutltifaceted biological roles of leptin
Mutltifaceted biological roles of leptin Open
The identification of leptin allowed the discovery of a new endocrine system. This major adipokine controlling energy homeostasis is also involved in the regulation of neuroendocrine function and fertility. Unfortunately, leptin is not abl…
View article: Serum level of HDL particles are independently associated with long-term prognosis in patients with coronary artery disease: The GENES study
Serum level of HDL particles are independently associated with long-term prognosis in patients with coronary artery disease: The GENES study Open
HDL-Cholesterol (HDL-C) is not an accurate surrogate marker to measure the cardioprotective functions of HDL in coronary artery diseases (CAD) patients. Hence, measurement of other HDL-related parameters may have prognostic superiority ove…
View article: A reference measurement of circulating ATPase inhibitory factor 1 (IF1) in humans by LC-MS/MS: comparison with conventional ELISA
A reference measurement of circulating ATPase inhibitory factor 1 (IF1) in humans by LC-MS/MS: comparison with conventional ELISA Open
ATPase inhibitory factor 1 (IF1) is a 9.5 kDa protein that binds to mitochondrial and plasma membrane ATP synthase and selectively inhibits ATP hydrolysis. Recently, IF1 was identified in systemic circulation in humans. IF1 appeared as an …
View article: Serum level of High-density lipoprotein particles are independently associated with long-term prognosis in patients with coronary artery disease: The GENES study
Serum level of High-density lipoprotein particles are independently associated with long-term prognosis in patients with coronary artery disease: The GENES study Open
BACKGROUND HDL-Cholesterol (HDL-C) is not an accurate surrogate marker to measure the cardioprotective functions of HDL in coronary artery diseases (CAD) patients. Hence, measurement of other HDL-related parameters may have prognostic supe…