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View article: A mass spectrometry-based proteomics strategy to detect long-chain <i>S</i>-acylated peptides
A mass spectrometry-based proteomics strategy to detect long-chain <i>S</i>-acylated peptides Open
Systematic evaluation of each step in the bottom-up proteomics workflow for its compatibility with long-chain S -acylated peptide detection.
View article: Design of linked-domain protein inhibitors of UBE2D as tools to study cellular ubiquitination
Design of linked-domain protein inhibitors of UBE2D as tools to study cellular ubiquitination Open
Ubiquitin (Ub) is a post-translational modification that largely controls proteostasis through mechanisms spanning transcription, translation, and notably, protein degradation. Ub conjugation occurs through a hierarchical cascade of three …
View article: <i>S</i>-Palmitoylation during Retinoic Acid-Induced Neuronal Differentiation of SH-SY5Y Neuroblastoma Cells
<i>S</i>-Palmitoylation during Retinoic Acid-Induced Neuronal Differentiation of SH-SY5Y Neuroblastoma Cells Open
S-Palmitoylation is the covalent attachment of C14:0-C22:0 fatty acids (mainly C16:0 palmitate) to cysteines via thioester bonds. This lipid modification is highly abundant in neurons, where it plays a role in neuronal development and is i…