Annette E. Neele
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View article: Human monocyte inflammation in patients with Lp(a) or atherosclerotic cardiovascular disease is not accompanied by changes in chromatin accessibility in circulating classical monocytes
Human monocyte inflammation in patients with Lp(a) or atherosclerotic cardiovascular disease is not accompanied by changes in chromatin accessibility in circulating classical monocytes Open
While subjects with high Lp(a) levels showed enhanced monocyte inflammation, no differences in chromatin accessibility were detected. This suggests that the pro-inflammatory signature of Lp(a) and ASCVD on monocytes is regulated at a level…
View article: Kynurenine and NAD+ Pathways are Associated with Macrophage Content and Polarization in Carotid Plaques
Kynurenine and NAD+ Pathways are Associated with Macrophage Content and Polarization in Carotid Plaques Open
Background and Aims Metabolism dictates macrophage function and plays a central role in atherosclerotic plaque progression. The kynurenine pathway, which metabolizes the majority of the essential amino acid tryptophan, plays a pivotal role…
View article: Novel insights into the dynamic function of PRC2 in innate immunity
Novel insights into the dynamic function of PRC2 in innate immunity Open
The polycomb repressive complex 2 (PRC2) is an established therapeutic target in cancer. PRC2 catalyzes methylation of histone H3 at lysine 27 (H3K27me3) and is known for maintaining eukaryote cell identity. Recent discoveries show that mo…
View article: Cardiovascular risk in ANCA-associated vasculitis: Monocyte phenotyping reveals distinctive signatures between serological subsets
Cardiovascular risk in ANCA-associated vasculitis: Monocyte phenotyping reveals distinctive signatures between serological subsets Open
These findings highlight changes in monocyte subset composition and activation, but not in the intrinsic migration capacity of AAV monocytes. MPO-AAV monocytes are associated with sustained upregulation of inflammatory genes, whereas PR3-A…
View article: Human atherosclerotic plaque macrophages associate with clinical presentation and follow diverse lineage differentiation routes
Human atherosclerotic plaque macrophages associate with clinical presentation and follow diverse lineage differentiation routes Open
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Dutch Research Council Veni grant. Netherlands Heart Foundation Atherosclerosis is characterized by inflammation and lipid ac…
View article: Untangling the inflammatory responses of liver x receptor (LXR) activation in human macrophages
Untangling the inflammatory responses of liver x receptor (LXR) activation in human macrophages Open
Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): Rembrandt Institute for Cardiovascular Science (grant 2022) The regulation of cholesterol and fatty acid homeostasis is essential and the Live…
View article: Infiltrative classical monocyte-derived and<i>SPP1</i>lipid-associated macrophages mediate inflammation and fibrosis in ANCA-associated glomerulonephritis
Infiltrative classical monocyte-derived and<i>SPP1</i>lipid-associated macrophages mediate inflammation and fibrosis in ANCA-associated glomerulonephritis Open
Background Kidney macrophage infiltration is a histological hallmark of vasculitic lesions and is strongly linked to disease activity in anti-neutrophil cytoplasmic antibodies (ANCA)-associated glomerulonephritis (AGN). The precise mechani…
View article: Targeting the ACOD1-itaconate axis stabilizes atherosclerotic plaques
Targeting the ACOD1-itaconate axis stabilizes atherosclerotic plaques Open
View article: Cardiovascular risk in ANCA-associated vasculitis: monocyte phenotyping reveals distinctive signatures between serological subsets
Cardiovascular risk in ANCA-associated vasculitis: monocyte phenotyping reveals distinctive signatures between serological subsets Open
Objectives Anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitides (AAV) is associated with an increased cardiovascular risk, particularly the myeloperoxidase AAV serotype (MPO-AAV). Distinct alterations in monocyte phenotype…
View article: Ezh2 emerges as an epigenetic checkpoint regulator during monocyte differentiation limiting cardiac dysfunction post-MI
Ezh2 emerges as an epigenetic checkpoint regulator during monocyte differentiation limiting cardiac dysfunction post-MI Open
View article: Hematopoietic Somatic Mosaicism Is Associated With an Increased Risk of Postoperative Atrial Fibrillation
Hematopoietic Somatic Mosaicism Is Associated With an Increased Risk of Postoperative Atrial Fibrillation Open
View article: DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability
DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability Open
View article: Monocyte and Macrophage Lipid Accumulation Results in Down-Regulated Type-I Interferon Responses
Monocyte and Macrophage Lipid Accumulation Results in Down-Regulated Type-I Interferon Responses Open
Macrophages are critical components of atherosclerotic lesions and their pro- and anti-inflammatory responses influence atherogenesis. Type-I interferons (IFNs) are cytokines that play an essential role in antiviral responses and inflammat…
View article: High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages
High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages Open
High titers and low fucosylation of human anti–spike protein IgG promote alveolar macrophage activation and inflammation.
View article: Myeloid Ezh2 Deficiency Limits Atherosclerosis Development
Myeloid Ezh2 Deficiency Limits Atherosclerosis Development Open
Macrophages define a key component of immune cells present in atherosclerotic lesions and are central regulators of the disease. Since epigenetic processes are important in controlling macrophage function, interfering with epigenetic pathw…
View article: Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques
Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques Open
Macrophages represent a major immune cell population in atherosclerotic plaques and play central role in the progression of this lipid-driven chronic inflammatory disease. Targeting immunometabolism is proposed as a strategy to revert aber…
View article: Targeting epigenetics as atherosclerosis treatment: an updated view
Targeting epigenetics as atherosclerosis treatment: an updated view Open
Purpose of review This review discusses the current developments on epigenetic inhibition as treatment for atherosclerosis. Recent findings The first phase III clinical trial targeting epigenetics in cardiovascular disease (CVD), BETonMACE…
View article: Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses
Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses Open
For yet unknown reasons, severely ill COVID-19 patients often become critically ill around the time of activation of adaptive immunity. Here, we show that anti-Spike IgG from serum of severely ill COVID-19 patients induces a hyper-inflamma…
View article: Peritoneal macrophages have an impaired immune response in obesity which can be reversed by subsequent weight loss
Peritoneal macrophages have an impaired immune response in obesity which can be reversed by subsequent weight loss Open
Introduction Obesity is recognized as a risk factor for various microbial infections. The immune system, which is affected by obesity, plays an important role in the pathophysiology of these infections and other obesity-related comorbiditi…
View article: Salt increases monocyte CCR2 expression and inflammatory responses in humans
Salt increases monocyte CCR2 expression and inflammatory responses in humans Open
Inflammation may play a role in the link between high salt intake and its deleterious consequences. However, it is unknown whether salt can induce proinflammatory priming of monocytes and macrophages in humans. We investigated the effects …
View article: Targeting Histone Deacetylases in Myeloid Cells Inhibits Their Maturation and Inflammatory Function With Limited Effects on Atherosclerosis
Targeting Histone Deacetylases in Myeloid Cells Inhibits Their Maturation and Inflammatory Function With Limited Effects on Atherosclerosis Open
Monocytes and macrophages are key drivers in the pathogenesis of inflammatory diseases. Epigenetic targets have been shown to control the transcriptional profile and phenotype of these cells. Since histone deacetylase protein inhibitors de…
View article: Nanoparticle-Aided Characterization of Arterial Endothelial Architecture during Atherosclerosis Progression and Metabolic Therapy
Nanoparticle-Aided Characterization of Arterial Endothelial Architecture during Atherosclerosis Progression and Metabolic Therapy Open
Atherosclerosis is associated with a compromised endothelial barrier, facilitating the accumulation of immune cells and macromolecules in atherosclerotic lesions. In this study, we investigate endothelial barrier integrity and the enhanced…
View article: Human monocyte-to-macrophage differentiation involves highly localized gain and loss of DNA methylation at transcription factor binding sites
Human monocyte-to-macrophage differentiation involves highly localized gain and loss of DNA methylation at transcription factor binding sites Open
Our study highlights the involvement of subtle, yet highly localized remodeling of DNA methylation at regulatory regions in cell differentiation.
View article: MOESM3 of Human monocyte-to-macrophage differentiation involves highly localized gain and loss of DNA methylation at transcription factor binding sites
MOESM3 of Human monocyte-to-macrophage differentiation involves highly localized gain and loss of DNA methylation at transcription factor binding sites Open
Additional file 3: Table S3 Chromatin states in monocytes and macrophages. Chromatin states in both monocytes and macrophages defined using a hidden Markov model based on H3K4me1, H3K4me3, H3K27ac and H3K27me3 histone marks available from …
View article: MOESM2 of Human monocyte-to-macrophage differentiation involves highly localized gain and loss of DNA methylation at transcription factor binding sites
MOESM2 of Human monocyte-to-macrophage differentiation involves highly localized gain and loss of DNA methylation at transcription factor binding sites Open
Additional file 2: Table S2 Differentially methylated CpGs (DMCs). The table includes all 5870 DMCs with the characteristics for each position. Column 1: CpG identifier, Column 2-4: Effect size (mean squares), F-statistic and P-value of th…
View article: A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia
A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia Open
Metabolic reprogramming has emerged as a crucial regulator of immune cell activation, but how systemic metabolism influences immune cell metabolism and function remains to be investigated. To investigate the effect of dyslipidemia on immun…
View article: Myeloid Kdm6b deficiency results in advanced atherosclerosis
Myeloid Kdm6b deficiency results in advanced atherosclerosis Open
View article: Repressing the repressor: Ezh2 mediates macrophage activation
Repressing the repressor: Ezh2 mediates macrophage activation Open
In this issue of JEM, Zhang et al. (https://doi.org/10.1084/jem.20171417) show that the suppressive epigenetic enzyme Ezh2 is an important regulator of macrophage activation. The absence of Ezh2 leads to reduced cytokine secretion and supp…
View article: Lipopolysaccharide Lowers Cholesteryl Ester Transfer Protein by Activating F4/80 <sup>+</sup> Clec4f <sup>+</sup> Vsig4 <sup>+</sup> Ly6C <sup>−</sup> Kupffer Cell Subsets
Lipopolysaccharide Lowers Cholesteryl Ester Transfer Protein by Activating F4/80 <sup>+</sup> Clec4f <sup>+</sup> Vsig4 <sup>+</sup> Ly6C <sup>−</sup> Kupffer Cell Subsets Open
Background Lipopolysaccharide ( LPS ) decreases hepatic CETP (cholesteryl ester transfer protein) expression albeit that the underlying mechanism is disputed. We recently showed that plasma CETP is mainly derived from Kupffer cells ( KC s)…
View article: Macrophage regulatory mechanisms in atherosclerosis : The interplay of lipids and inflammation
Macrophage regulatory mechanisms in atherosclerosis : The interplay of lipids and inflammation Open
Atherosclerosis is a lipid driven chronic inflammatory disorder of the arteries. Monocytes, macrophages and foam cells are the central players in atherosclerosis and contribute to all stages of lesion formation. Skewing monocytes and macro…