Annette Gärtner
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View article: Suppression of Huntington’s Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding
Suppression of Huntington’s Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding Open
Huntington’s disease (HD) arises from a CAG expansion in the huntingtin ( HTT ) gene beyond a critical threshold. A major thrust of current HD therapeutic development is lowering levels of mutant HTT mRNA (m HTT ) and protein (mHTT) with t…
View article: Increased <scp>PD</scp>‐1/<scp>PD</scp>‐<scp>L1</scp> Immune Checkpoint Expression Is Associated With Oral Squamous Cell Carcinoma in Never‐Smokers and Never‐Drinkers
Increased <span>PD</span>‐1/<span>PD</span>‐<span>L1</span> Immune Checkpoint Expression Is Associated With Oral Squamous Cell Carcinoma in Never‐Smokers and Never‐Drinkers Open
Background This study aimed to explore the disparities in PD‐1 and PD‐L1 expression among oral squamous cell carcinomas (OSCCs) in individuals categorized as never‐smokers/never‐drinkers versus smokers/drinkers. Methods Immunohistochemical…
View article: Crystal structure of human peptidylarginine deiminase type VI (PAD6) provides insights into its inactivity
Crystal structure of human peptidylarginine deiminase type VI (PAD6) provides insights into its inactivity Open
Human peptidylarginine deiminase isoform VI (PAD6), which is predominantly limited to cytoplasmic lattices in the mammalian oocytes in ovarian tissue, is essential for female fertility. It belongs to the peptidylarginine deiminase (PAD) en…
View article: Development of a ligand for in vivo imaging of mutant huntingtin in Huntington’s disease
Development of a ligand for in vivo imaging of mutant huntingtin in Huntington’s disease Open
Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in the huntingtin ( HTT ) gene that encodes the pathologic mutant HTT (mHTT) protein with an expanded polyglutamine (pol…
View article: A novel imaging ligand as a biomarker for mutant huntingtin-lowering in Huntington’s disease
A novel imaging ligand as a biomarker for mutant huntingtin-lowering in Huntington’s disease Open
Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in the huntingtin ( HTT ) gene that encodes the pathologic mutant HTT (mHTT) protein with an expanded polyglutamine (Pol…
View article: Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse
Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse Open
SummaryBACE1 is the major drug target for Alzheimer's disease, but we know surprisingly little about its normal function in the CNS. Here, we show that this protease is critically involved in semaphorin 3A (Sema3A)-mediated axonal guidance…
View article: Editorial Expression of Concern: Glial β-Oxidation regulates Drosophila Energy Metabolism
Editorial Expression of Concern: Glial β-Oxidation regulates Drosophila Energy Metabolism Open
View article: The long noncoding RNA <i>neuroLNC</i> regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43
The long noncoding RNA <i>neuroLNC</i> regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43 Open
NeuroLNC , a previously unknown long ncRNA, regulates neuronal activity by interacting with the neurodegeneration protein TDP-43.
View article: Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse
Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse Open
View article: Maternal immune activation evoked by polyinosinic:polycytidylic acid does not evoke microglial cell activation in the embryo
Maternal immune activation evoked by polyinosinic:polycytidylic acid does not evoke microglial cell activation in the embryo Open
Several studies have indicated that inflammation during pregnancy increases the risk for the development of neuropsychiatric disorders in the offspring. Morphological brain abnormalities combined with deviations in the inflammatory status …
View article: Glial β-Oxidation regulates Drosophila Energy Metabolism
Glial β-Oxidation regulates Drosophila Energy Metabolism Open
The brain's impotence to utilize long-chain fatty acids as fuel, one of the dogmas in neuroscience, is surprising, since the nervous system is the tissue most energy consuming and most vulnerable to a lack of energy. Challenging this view,…