Annika Döding
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View article: Human platelet-derived extracellular vesicle fractions modulate bone cell metabolism and biologize volume-stable β-TCP matrix in vitro
Human platelet-derived extracellular vesicle fractions modulate bone cell metabolism and biologize volume-stable β-TCP matrix in vitro Open
View article: Fighting Age-Associated Bone Loss in Periodontitis with Dietary Interventions
Fighting Age-Associated Bone Loss in Periodontitis with Dietary Interventions Open
Aging is a systemic immunomodulatory condition that makes organisms more susceptible to infection-driven periodontitis and associated periodontal tissue loss. Therefore, modulation of the bacterial-induced inflammatory host response could …
View article: Evaluation of a nucleic acid preservation protocol for microbiome studies involving samples from the oral cavity
Evaluation of a nucleic acid preservation protocol for microbiome studies involving samples from the oral cavity Open
Storing oral samples at room temperature in DNA/RNA Shield buffer provides a reliable and efficient alternative to freezing for preserving microbiome samples. Furthermore, it may enhance DNA yield while preserving microbial diversity in th…
View article: GDF15 modulates aging-associated adaptions in the mechanoresponse of periodontal ligament fibroblasts
GDF15 modulates aging-associated adaptions in the mechanoresponse of periodontal ligament fibroblasts Open
Purpose This in vitro study aimed to examine aging-associated adaptations in the mechanoresponse of periodontal ligament fibroblasts (PdLFs) and explore a potential regulatory role of growth differentiation factor 15 (GDF15). Methods Repli…
View article: Mediterranean diet component oleic acid decreases systemic impact of periodontal Porphyromonas gingivalis-infection in age: addressing role of stress resistance and microbiome
Mediterranean diet component oleic acid decreases systemic impact of periodontal Porphyromonas gingivalis-infection in age: addressing role of stress resistance and microbiome Open
Periodontitis (PD) is an age-associated infectious periodontal disease driven by dysbiosis and hyperinflammatory host response, resulting in bone and tissue loss. Often linked to systemic inflammatory comorbidities, modulating host respons…
View article: The effects of saturated and unsaturated fatty acids on MASLD: a Mendelian randomization analysis and in vivo experiment
The effects of saturated and unsaturated fatty acids on MASLD: a Mendelian randomization analysis and in vivo experiment Open
View article: GDF15 Modulates the Zoledronic-Acid-Induced Hyperinflammatory Mechanoresponse of Periodontal Ligament Fibroblasts
GDF15 Modulates the Zoledronic-Acid-Induced Hyperinflammatory Mechanoresponse of Periodontal Ligament Fibroblasts Open
Orthodontic tooth movement (OTM) is thought to be impeded by bisphosphonate (BP) therapy, mainly due to increased osteoclast apoptosis and changes in the periodontal ligament (PdL), a connecting tissue between the alveolar bone and teeth. …
View article: Immunometabolic capacities of nutritional fatty acids in regulation of inflammatory bone cell interaction and systemic impact of periodontal infection
Immunometabolic capacities of nutritional fatty acids in regulation of inflammatory bone cell interaction and systemic impact of periodontal infection Open
Introduction Novel preventive strategies in periodontal disease target the bacterial-induced inflammatory host response to reduce associated tissue destruction. Strategies focus on the modulation of tissue-destroying inflammatory host resp…
View article: Mediterranean diet component oleic acid increases protective lipid mediators and improves trabecular bone in a <i>Porphyromonas gingivalis</i> inoculation model
Mediterranean diet component oleic acid increases protective lipid mediators and improves trabecular bone in a <i>Porphyromonas gingivalis</i> inoculation model Open
Aim Therapeutic modulation of bacterial‐induced inflammatory host response is being investigated in gingival inflammation and periodontal disease pathology. Therefore, dietary intake of the monounsaturated fatty acid (FA) oleic acid (OA (C…
View article: PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling
PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling Open
Cytotoxic stress activates stress-activated kinases, initiates adaptive mechanisms, including the unfolded protein response (UPR) and autophagy, and induces programmed cell death. Fatty acid unsaturation, controlled by stearoyl-CoA desatur…
View article: Palmitate-Triggered COX2/PGE2-Related Hyperinflammation in Dual-Stressed PdL Fibroblasts Is Mediated by Repressive H3K27 Trimethylation
Palmitate-Triggered COX2/PGE2-Related Hyperinflammation in Dual-Stressed PdL Fibroblasts Is Mediated by Repressive H3K27 Trimethylation Open
The interrelationships between periodontal disease, obesity-related hyperlipidemia and mechanical forces and their modulating effects on the epigenetic profile of periodontal ligament (PdL) cells are assumed to be remarkably complex. The P…
View article: Palmitate-triggered COX2/PGE2-Mediated Hyperinflammation In Dual-stressed Pdl Fibroblasts Is Mediated by Repressive H3K27 Trimethylation
Palmitate-triggered COX2/PGE2-Mediated Hyperinflammation In Dual-stressed Pdl Fibroblasts Is Mediated by Repressive H3K27 Trimethylation Open
The interrelationship between periodontal disease, obesity-related hyperlipidemia and mechanical forces as well as their modulating effects on the epigenetic profile of periodontal ligament (PdL) cells are assumed to be remarkably complex.…
View article: Hyperlipidemic Conditions Impact Force-Induced Inflammatory Response of Human Periodontal Ligament Fibroblasts Concomitantly Challenged with P. gingivalis-LPS
Hyperlipidemic Conditions Impact Force-Induced Inflammatory Response of Human Periodontal Ligament Fibroblasts Concomitantly Challenged with P. gingivalis-LPS Open
In obese patients, enhanced serum levels of free fatty acids (FFA), such as palmitate (PA) or oleate (OA), are associated with an increase in systemic inflammatory markers. Bacterial infection during periodontal disease also promotes local…
View article: Distinguish fatty acids impact survival, differentiation and cellular function of periodontal ligament fibroblasts
Distinguish fatty acids impact survival, differentiation and cellular function of periodontal ligament fibroblasts Open