Annika Reynberg Langkilde
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View article: Prenatal diagnosis of anomalies in the central nervous system
Prenatal diagnosis of anomalies in the central nervous system Open
Anomalies of the central nervous system (CNS) are some of the most common anomalies in the fetus. Severe neural tube defects can be detected by ultrasound in the 1st trimester. An accurate diagnosis at the prenatal ultrasound is essential …
View article: Risk of T2 lesions when discontinuing fingolimod: a nationwide predictive and comparative study
Risk of T2 lesions when discontinuing fingolimod: a nationwide predictive and comparative study Open
Fingolimod is a frequently used disease-modifying therapy in relapsing–remitting multiple sclerosis. However, case reports and small observational studies indicate a highly increased risk of disease reactivation after discontinuation. We a…
View article: Artificial Intelligence for Automated DWI/FLAIR Mismatch Assessment on Magnetic Resonance Imaging in Stroke: A Systematic Review
Artificial Intelligence for Automated DWI/FLAIR Mismatch Assessment on Magnetic Resonance Imaging in Stroke: A Systematic Review Open
We conducted this Systematic Review to create an overview of the currently existing Artificial Intelligence (AI) methods for Magnetic Resonance Diffusion-Weighted Imaging (DWI)/Fluid-Attenuated Inversion Recovery (FLAIR)—mismatch assessmen…
View article: Scanner agnostic large-scale evaluation of MS lesion delineation tool for clinical MRI
Scanner agnostic large-scale evaluation of MS lesion delineation tool for clinical MRI Open
Introduction Patients with MS are MRI scanned continuously throughout their disease course resulting in a large manual workload for radiologists which includes lesion detection and size estimation. Though many models for automatic lesion s…
View article: Using both electromyography and movement disorder assessment improved the classification of children with dyskinetic cerebral palsy
Using both electromyography and movement disorder assessment improved the classification of children with dyskinetic cerebral palsy Open
Aim Children with dyskinetic cerebral palsy (CP) are often severely affected and effective treatment is difficult, due to different underlying disease mechanisms. Comprehensive systematic movement disorder evaluations were carried out on p…
View article: MRI of the Entire Spinal Cord—Worth the While or Waste of Time? A Retrospective Study of 74 Patients with Multiple Sclerosis
MRI of the Entire Spinal Cord—Worth the While or Waste of Time? A Retrospective Study of 74 Patients with Multiple Sclerosis Open
Spinal cord lesions are included in the diagnosis of multiple sclerosis (MS), yet spinal cord MRI is not mandatory for diagnosis according to the latest revisions of the McDonald Criteria. We investigated the distribution of spinal cord le…
View article: Circulating levels of tight junction proteins in multiple sclerosis: Association with inflammation and disease activity before and after disease modifying therapy
Circulating levels of tight junction proteins in multiple sclerosis: Association with inflammation and disease activity before and after disease modifying therapy Open
Background: Tight junction proteins contribute to maintenance of epithelial and endothelial barriers such as the intestinal barrier and the blood brain barrier (BBB). Increased permeability of these barriers has been linked to disease acti…
View article: Serum Short-Chain Fatty Acids and Associations With Inflammation in Newly Diagnosed Patients With Multiple Sclerosis and Healthy Controls
Serum Short-Chain Fatty Acids and Associations With Inflammation in Newly Diagnosed Patients With Multiple Sclerosis and Healthy Controls Open
Multiple sclerosis (MS) is a chronic immune-mediated disease characterized by demyelination and neuroaxonal damage in the central nervous system. The etiology is complex and is still not fully understood. Accumulating evidence suggests tha…
View article: Central and peripheral nervous system complications of COVID-19: A prospective tertiary center cohort with 3-month follow-up
Central and peripheral nervous system complications of COVID-19: A prospective tertiary center cohort with 3-month follow-up Open
Objective To systematically describe CNS and PNS complications in hospitalized COVID-19 patients. Methods We conducted a prospective, consecutive, observational study of adult patients from a tertiary referral center with confirmed COVID-1…
View article: Associations between mean arterial pressure during cardiopulmonary bypass and biomarkers of cerebral injury in patients undergoing cardiac surgery: secondary results from a randomized controlled trial
Associations between mean arterial pressure during cardiopulmonary bypass and biomarkers of cerebral injury in patients undergoing cardiac surgery: secondary results from a randomized controlled trial Open
OBJECTIVES Cardiac surgery is associated with risk of cerebral injury and mean arterial pressure (MAP) during cardiopulmonary bypass (CPB) is suggested to be associated with cerebral injury. The ‘Perfusion Pressure Cerebral Infarcts’ (PPCI…
View article: Blood pressure and brain injury in cardiac surgery: a secondary analysis of a randomized trial
Blood pressure and brain injury in cardiac surgery: a secondary analysis of a randomized trial Open
OBJECTIVES Brain dysfunction is a serious complication after cardiac surgery. In the Perfusion Pressure Cerebral Infarcts trial, we allocated cardiac surgery patients to a mean arterial pressure of either 70–80 or 40–50 mmHg during cardiop…
View article: Fatal case of hospital-acquired hypernatraemia in a neonate: lessons learned from a tragic error
Fatal case of hospital-acquired hypernatraemia in a neonate: lessons learned from a tragic error Open
A 3-week-old boy with viral gastroenteritis was by error given 200 mL 1 mmol/mL hypertonic saline intravenously instead of isotonic saline. His plasma sodium concentration (PNa) increased from 136 to 206 mmol/L. Extreme brain shrinkage and…