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View article: A novel strategy to target metabolic dependencies in acute myeloid leukemia
A novel strategy to target metabolic dependencies in acute myeloid leukemia Open
View article: Impact of cancer and therapy on the epigenetic landscapes of normal cells: Describing a novel biomarker in survivorship
Impact of cancer and therapy on the epigenetic landscapes of normal cells: Describing a novel biomarker in survivorship Open
Introduction: With the advent of modern multi-drug chemotherapy regimens, several aggressive hematologic malignancies now have excellent outcomes. However, long-term follow-up studies show increased incidences of secondary malignancies, li…
View article: NuPOWER (Nuwiq for Perioperative management Of patients With haemophilia A on Emicizumab Regular prophylaxis): protocol for an open-label, single-arm, multicentre study
NuPOWER (Nuwiq for Perioperative management Of patients With haemophilia A on Emicizumab Regular prophylaxis): protocol for an open-label, single-arm, multicentre study Open
Introduction Despite the known haemostatic action of emicizumab (Hemlibra) in haemophilia A patients, its role in the prevention and control of bleeding in high-demand haemostatic situations, such as major surgery, remains to be determined…
View article: Clinical Presentation, Microbiological Profile, Treatment Outcome, and Predictors of Outcome in Patients with Nontuberculous Mycobacteria Bloodstream Infection
Clinical Presentation, Microbiological Profile, Treatment Outcome, and Predictors of Outcome in Patients with Nontuberculous Mycobacteria Bloodstream Infection Open
Background: Nontuberculous mycobacteria (NTM) are ubiquitous organisms with varied clinical syndromes. We conducted this study to identify the clinical spectrum, microbiological diagnosis, outcomes, and predictors of outcome in patients wi…
View article: Real‐World Unmet Needs of Patients With Haemophilia A and Haemophilia B With or Without Inhibitors: End‐of‐Study Results From the explorer6 Non‐Interventional Study
Real‐World Unmet Needs of Patients With Haemophilia A and Haemophilia B With or Without Inhibitors: End‐of‐Study Results From the explorer6 Non‐Interventional Study Open
Introduction Haemophilia is associated with high disease and treatment burdens. Prospective evaluation of data from patients with haemophilia helps understand and define unmet needs, optimise treatment and improve healthcare outcomes. Aim …
View article: Safety, efficacy and total cost of point-of-care manufactured anti-CD19 CAR-T cell therapy in India: VELCART trial
Safety, efficacy and total cost of point-of-care manufactured anti-CD19 CAR-T cell therapy in India: VELCART trial Open
Decentralized or point-of-care (POC) manufacture of CAR-T cells is a potential strategy to improve accessibility and reduce cost and logistic challenges. A total of 10 relapsed/refractory patients (B cell acute lymphoblastic leukemia [B-AL…
View article: Outcomes and prognostic factors in patients with Burkitt lymphoma/leukemia in adolescents and adults: an experience from hematology cancer consortium
Outcomes and prognostic factors in patients with Burkitt lymphoma/leukemia in adolescents and adults: an experience from hematology cancer consortium Open
View article: REAL-WORLD OUTCOMES OF STEROID-REFRACTORY ACUTE GRAFT-VERSUS-HOST DISEASE TREATED WITH RUXOLITINIB
REAL-WORLD OUTCOMES OF STEROID-REFRACTORY ACUTE GRAFT-VERSUS-HOST DISEASE TREATED WITH RUXOLITINIB Open
Acute graft-versus-host disease (aGVHD) is a life-threatening complication that can develop after allogeneic hematopoietic stem cell transplantation. Patients with steroid-refractory aGVHD (SR-aGVHD) have an extremely poor prognosis. Ruxol…
View article: Outcomes in patients undergoing hematopoietic stem cell transplantation for myelodysplastic syndromes
Outcomes in patients undergoing hematopoietic stem cell transplantation for myelodysplastic syndromes Open
Hematopoietic stem cell transplantation [HSCT] is the only curative option for patients with myelodysplastic syndromes [MDS]. Between 1991 and 2021, 154 patients [high risk, 86; low risk, 68] including 22 children underwent HSCT with a med…
View article: Lentiviral Gene Therapy with CD34+ Hematopoietic Cells for Hemophilia A
Lentiviral Gene Therapy with CD34+ Hematopoietic Cells for Hemophilia A Open
Gene therapy for hemophilia A with the use of lentiviral vector-transduced autologous HSCs resulted in stable factor VIII expression, with factor VIII activity correlating to vector copy number in the peripheral blood. (Funded by the Minis…
View article: Assessing the impact of climate change on reproductive health: A content analysis of climate journalism coverage
Assessing the impact of climate change on reproductive health: A content analysis of climate journalism coverage Open
This research explores the intricate relationship between climate change and reproductive health through an analysis of 1000 global news articles from 2018 onwards. Utilizing Latent Dirichlet Allocation (LDA), key topics in media coverage …
View article: Higher prevalence of poor prognostic markers at a younger age in adult patients with myelodysplastic syndrome – evaluation of a large cohort in India
Higher prevalence of poor prognostic markers at a younger age in adult patients with myelodysplastic syndrome – evaluation of a large cohort in India Open
The most significant finding of this cytogenetic analysis of MDS in India is that abnormal karyotypes with poor prognosis markers including monosomy 7 and CK were more frequent than in most other reports, among patients who were overall yo…
View article: Targeting Metabolic Dependencies in Acute Myeloid Leukemia: A Dual Strategy using Arsenic Trioxide and Artesunate
Targeting Metabolic Dependencies in Acute Myeloid Leukemia: A Dual Strategy using Arsenic Trioxide and Artesunate Open
Acute myeloid leukemia (AML) remains a difficult disease to cure despite recent advances. Off-target side effects of therapy, especially prolonged cytopenia, lead to significant morbidity and mortality. There is an increased recognition th…
View article: Concizumab prophylaxis in persons with hemophilia A or B with inhibitors: patient-reported outcome results from the phase 3 explorer7 study
Concizumab prophylaxis in persons with hemophilia A or B with inhibitors: patient-reported outcome results from the phase 3 explorer7 study Open
View article: Treatment challenges and outcomes of older patients with acute myeloid leukemia from India
Treatment challenges and outcomes of older patients with acute myeloid leukemia from India Open
Globally, overall survival (OS) of older patients with AML continues to be suboptimal with very little data from India. In a multicenter registry analysis, we evaluated 712 patients with AML older than 55 years. Only 323 (45.3%) underwent …
View article: Ablation of Wnt signaling in bone marrow stromal cells overcomes microenvironment-mediated drug resistance in acute myeloid leukemia
Ablation of Wnt signaling in bone marrow stromal cells overcomes microenvironment-mediated drug resistance in acute myeloid leukemia Open
View article: Does Upper Incisors Procline following Rapid Maxillary Expansion Facemask Therapy?
Does Upper Incisors Procline following Rapid Maxillary Expansion Facemask Therapy? Open
Background: The present study is intended to evaluate the changes in upper incisor angulation, skeletal and dental parameters, soft-tissue and airway dimensions following rapid palatal expansion and maxillary protraction. Materials and Met…
View article: WCN24-1135 Cryptococcal Infections in renal transplantation : A single centre experience
WCN24-1135 Cryptococcal Infections in renal transplantation : A single centre experience Open
Cryptococcosis is a significant opportunistic infection affecting 2.8-5% of the transplant patients. Mortality ranges from 20- 42%; patients with central nervous system infection has moratality rate of about 50%. In this study I would like…
View article: Successful Hematopoietic Stem Cell Transplantation in a Child with Thalassemia major and Moderate Haemophilia A
Successful Hematopoietic Stem Cell Transplantation in a Child with Thalassemia major and Moderate Haemophilia A Open
View article: Cystatin F a potential diagnostic biomarker in acute promyelocytic leukemia
Cystatin F a potential diagnostic biomarker in acute promyelocytic leukemia Open
View article: Morphology And Bridging Of Sella Turcica In Skeletal Class I And Class III Subjects Of South Indian Population: A Cephalometric Cross Sectional Study.
Morphology And Bridging Of Sella Turcica In Skeletal Class I And Class III Subjects Of South Indian Population: A Cephalometric Cross Sectional Study. Open
View article: Early detection, reactivation of cytomegalovirus DNA & immediate early (IE)-mRNA expression in hematopoietic stem cell-transplant patients
Early detection, reactivation of cytomegalovirus DNA & immediate early (IE)-mRNA expression in hematopoietic stem cell-transplant patients Open
Quantification of HCMV IE-mRNA may be a valuable tool to predict progression of HCMV infection post-transplantation, with further prospective studies needed for validation.
View article: Rotational Thromboelastometry Reduces Fresh Frozen Plasma Requirement in Patients without Liver Disease Undergoing Therapeutic Endoscopic Procedures with Deranged Screening Coagulation Tests—A Pilot Study
Rotational Thromboelastometry Reduces Fresh Frozen Plasma Requirement in Patients without Liver Disease Undergoing Therapeutic Endoscopic Procedures with Deranged Screening Coagulation Tests—A Pilot Study Open
Background/Aims Rotational thromboelastometry (ROTEM) is a viscoelastic test that is used in patients with liver disease for guiding blood component use. This study is aimed at comparing the amount of blood products transfused and bleeding…
View article: M19 Management of uncontrolled asthma in pregnancy: challenges and concerns
M19 Management of uncontrolled asthma in pregnancy: challenges and concerns Open
Introduction Management of uncontrolled, moderate-to-severe asthma during pregnancy can be challenging. Despite advances in treatments, a limited evidence base and potential maternal and foetal risks can result in clinician uncertainty and…
View article: Issue Information
Issue Information Open
View article: Speckle tracking echocardiography-derived left ventricular global longitudinal strain in ex-thalassaemics
Speckle tracking echocardiography-derived left ventricular global longitudinal strain in ex-thalassaemics Open
Aims Long term survivors of haematopoietic stem cell transplantation (HSCT) for β-thalassemia major are designated “ex-thalassaemics”. Whether ex-thalassaemics continue to harbour residual myocardial dysfunction and thereby stand the risk …
View article: Treosulfan Exposure Predicts Thalassemia‐Free Survival in Patients with Beta Thalassemia Major Undergoing Allogeneic Hematopoietic Cell Transplantation
Treosulfan Exposure Predicts Thalassemia‐Free Survival in Patients with Beta Thalassemia Major Undergoing Allogeneic Hematopoietic Cell Transplantation Open
A toxicity‐reduced conditioning regimen with treosulfan, fludarabine, and thiotepa in patients with high‐risk β‐thalassemia major has significantly improved hematopoietic stem cell transplantation (HCT) outcomes. However, complications res…
View article: HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH HEMOPHILIA A OR B WITH INHIBITORS ON CONCIZUMAB PROPHYLAXIS: RESULTS FROM THE PHASE 3 EXPLORER7 STUDY
HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH HEMOPHILIA A OR B WITH INHIBITORS ON CONCIZUMAB PROPHYLAXIS: RESULTS FROM THE PHASE 3 EXPLORER7 STUDY Open
Introduction: Concizumab is a humanised, monoclonal anti-tissue factor pathway inhibitor antibody. In explorer7, a phase 3 study (NCT04083781), patients with haemophilia A or B with inhibitors (HAwI/HBwI) received once-daily subcutaneous p…
View article: Improving Outcomes with Haploidentical Stem Cell Transplantation [HaploSCT] in Children Using Post-transplant Cyclophosphamide: a Single Center Experience
Improving Outcomes with Haploidentical Stem Cell Transplantation [HaploSCT] in Children Using Post-transplant Cyclophosphamide: a Single Center Experience Open
View article: Cytogenetic profile of 1791 adult acute myeloid leukemia in India
Cytogenetic profile of 1791 adult acute myeloid leukemia in India Open
Background Cytogenetic analysis continues to have an important role in the management of acute myeloid leukemia (AML) because it is essential for prognostication. It is also necessary to diagnose specific categories of AML and to determine…