Annunziata Corteggio
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View article: PNA-SERS biosensor for label-free detection of SARS-CoV-2 genomic sequences in saliva
PNA-SERS biosensor for label-free detection of SARS-CoV-2 genomic sequences in saliva Open
The COVID-19 pandemic has emphasized the need for rapid, sensitive, and accessible molecular diagnostics. In this study, we present a label-free Surface-Enhanced Raman Spectroscopy (SERS) biosensor for the direct detection of SARS-CoV-2 RN…
View article: Safety of Zein Nanoparticles on Human Innate Immunity and Inflammation
Safety of Zein Nanoparticles on Human Innate Immunity and Inflammation Open
In recent years, natural polymers have attracted great interest for the development of release systems for vaccine formulations and drug delivery. Zein, a hydrophobic proline-rich protein mixture obtained from maize, is one of the most wid…
View article: PEI‐Engineered Lipid@PLGA Hybrid Nanoparticles for Multimodal Delivery of Antigens and Immune Adjuvants to the Respiratory Mucosa
PEI‐Engineered Lipid@PLGA Hybrid Nanoparticles for Multimodal Delivery of Antigens and Immune Adjuvants to the Respiratory Mucosa Open
Antigen delivery via respiratory mucosal surfaces is an interesting needle‐free option for vaccination. Nonetheless, it demands for the design of especially tailored formulations. Here, lipid/poly(lactic‐co‐glycolic) acid (PLGA) hybrid nan…
View article: Deregulation of Metalloproteinase Expression in Gray Horse Melanoma Ex Vivo and In Vitro
Deregulation of Metalloproteinase Expression in Gray Horse Melanoma Ex Vivo and In Vitro Open
The ability of human melanoma cells to switch from an epithelial to a mesenchymal phenotype contributes to the metastatic potential of disease. Metalloproteinases (MPs) are crucially involved in this process by promoting the detachment of …
View article: Monoclonal antibody cetuximab impairs matrix metalloproteinases 2 and 9, epithelial–mesenchymal transition and cell migration in feline oral squamous cell carcinoma in vitro
Monoclonal antibody cetuximab impairs matrix metalloproteinases 2 and 9, epithelial–mesenchymal transition and cell migration in feline oral squamous cell carcinoma in vitro Open
Feline oral squamous cell carcinoma (FOSCC) is characterised by invasive and metastatic behaviour and is poorly responsive to current treatments, hence the need for new therapeutic strategies. FOSCC shares molecular targets with human head…
View article: EFSA Pilot Project on NAMs for the hazard assessment of nanofibers. Lot 2: ‘Exploring the use of gut‐on‐a‐chip models for risk assessments of nanofibers’
EFSA Pilot Project on NAMs for the hazard assessment of nanofibers. Lot 2: ‘Exploring the use of gut‐on‐a‐chip models for risk assessments of nanofibers’ Open
The present project aimed to improve our understanding of potential effect of nanocellulose (NC) ingestion on human health, addressing some key objectives set by the European Food Safety Authority (EFSA). In particular, the use and improve…
View article: Expression of collagenases (matrix metalloproteinase-1, -8, -13) and tissue inhibitor of metalloproteinase-3 (TIMP-3) in naturally occurring bovine cutaneous fibropapillomas
Expression of collagenases (matrix metalloproteinase-1, -8, -13) and tissue inhibitor of metalloproteinase-3 (TIMP-3) in naturally occurring bovine cutaneous fibropapillomas Open
Bovine cutaneous fibropapillomas are among the most common skin tumors in cattle; their etiology is associated with infection by bovine papillomavirus (BPV) types−1/-2 which are considered oncogenic. Degradation of the extracellular matrix…
View article: Expression of matrix metalloproteinases (MMPs)−2/-7/-9/-14 and tissue inhibitors of MMPs (TIMPs)−1/-2 in bovine cutaneous fibropapillomas associated with BPV-2 infection
Expression of matrix metalloproteinases (MMPs)−2/-7/-9/-14 and tissue inhibitors of MMPs (TIMPs)−1/-2 in bovine cutaneous fibropapillomas associated with BPV-2 infection Open
Introduction Bovine papillomaviruses −1/−2 (BPVs) are small non-enveloped double-stranded DNA viruses able to infect the skin of bovids and equids, causing development of neoplastic lesions such as bovine cutaneous fibropapillomas and equi…
View article: The endocytic recycling pathway is controlled by the ADP-ribosylated GTPase Rab14
The endocytic recycling pathway is controlled by the ADP-ribosylated GTPase Rab14 Open
The GTPase Rab14 is localized at the trans-Golgi network and at the intermediate compartment associated to sorting/recycling endosomes-like structures of the transferrin-recycling pathway: as other Rab family members, it is involved in the…
View article: Methodological Approaches To Assess Innate Immunity and Innate Memory in Marine Invertebrates and Humans
Methodological Approaches To Assess Innate Immunity and Innate Memory in Marine Invertebrates and Humans Open
Assessing the impact of drugs and contaminants on immune responses requires methodological approaches able to represent real-life conditions and predict long-term effects. Innate immunity/inflammation is the evolutionarily most widespread …
View article: Personalised Profiling of Innate Immune Memory Induced by Nano-Imaging Particles in Human Monocytes
Personalised Profiling of Innate Immune Memory Induced by Nano-Imaging Particles in Human Monocytes Open
Engineered nanoparticles used for medical purposes must meet stringent safety criteria, which include immunosafety, i.e. , the inability to activate possibly detrimental immune/inflammatory effects. Even medical nanomaterials devoid of dir…
View article: Targeting ADP-ribosylation as an antimicrobial strategy
Targeting ADP-ribosylation as an antimicrobial strategy Open
View article: Extracellular matrix remodeling in equine sarcoid: an immunohistochemical and molecular study
Extracellular matrix remodeling in equine sarcoid: an immunohistochemical and molecular study Open
This study revealed that in equine sarcoids exhibit an altered turnover of the Extracellular Matrix (ECM) deposition and degradation, as result of an altered expression of MMPs and TIMPs. Therefore, these observations seem to confirm that …
View article: Expression of Cyclooxygenase-2 in naturally occurring bovine cutaneous fibropapillomas
Expression of Cyclooxygenase-2 in naturally occurring bovine cutaneous fibropapillomas Open
Bovine cutaneous fibropapillomas are benign skin tumours characterized by epithelial and dermal proliferation and induced by Bovine papillomaviruses (BPVs). Cyclooxygenase (COX) 1 and 2 are enzymes involved in pathological conditions, such…
View article: Expression of bcl-2 and p53 in bovine cutaneous fibropapillomas
Expression of bcl-2 and p53 in bovine cutaneous fibropapillomas Open