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View article: Exploring bacterial and eukaryotic communities in the gut microbiota of urban and rural cats (Felis catus) in Colombia
Exploring bacterial and eukaryotic communities in the gut microbiota of urban and rural cats (Felis catus) in Colombia Open
Cats are essential companions to humans, offering emotional support while potentially harboring infectious agents. Understanding the gut microbiota of domestic cats ( Felis catus ) is critical for advancing feline health and examining envi…
View article: Impact of early life antibiotic and probiotic treatment on gut microbiome and resistome of very-low-birth-weight preterm infants
Impact of early life antibiotic and probiotic treatment on gut microbiome and resistome of very-low-birth-weight preterm infants Open
Preterm infants (300 metagenome-assembled genomes and obtained ~90 isolate genomes via targeted culturomics, allowing strain-level analysis. We also assessed ex vivo horizontal gene transfer (HGT) capacity of multidrug-resistant (MDR) Ente…
View article: Clostridium perfringens in central Colombia: frequency, toxin genes, and risk factors
Clostridium perfringens in central Colombia: frequency, toxin genes, and risk factors Open
Clostridium perfringens is an opportunistic bacterium that causes intestinal diseases in both humans and animals . This study aimed to assess the frequency of C. perfringens and the presence of toxin-encoding genes in fecal samples from in…
View article: Unveiling the pathogenic mechanisms of <i>Clostridium perfringens</i> toxins and virulence factors
Unveiling the pathogenic mechanisms of <i>Clostridium perfringens</i> toxins and virulence factors Open
Clostridium perfringens causes multiple diseases in humans and animals. Its pathogenic effect is supported by a broad and heterogeneous arsenal of toxins and other virulence factors associated with a specific host tropism. Molecular approa…
View article: Acquisition site-based remodelling of Clostridium perfringens- and Clostridioides difficile-related gut microbiota
Acquisition site-based remodelling of Clostridium perfringens- and Clostridioides difficile-related gut microbiota Open
The alterations reported herein may have been influenced by C. difficile and diarrhoea acquisition site, despite C. perfringens' ability to cause alterations in microbiota due to its virulence factors. Our findings highlight the need for a…
View article: Intra-species diversity of Clostridium perfringens: A diverse genetic repertoire reveals its pathogenic potential
Intra-species diversity of Clostridium perfringens: A diverse genetic repertoire reveals its pathogenic potential Open
Clostridium perfringens is the causative agent of many enterotoxic diseases in humans and animals, and it is present in diverse environments (soil, food, sewage, and water). Multilocus Sequence Typing (MLST) and Whole Genome Sequencing (WG…
View article: The First Chemically-Synthesised, Highly Immunogenic Anti-SARS-CoV-2 Peptides in DNA Genotyped Aotus Monkeys for Human Use
The First Chemically-Synthesised, Highly Immunogenic Anti-SARS-CoV-2 Peptides in DNA Genotyped Aotus Monkeys for Human Use Open
Thirty-five peptides selected from functionally-relevant SARS-CoV-2 spike (S), membrane (M), and envelope (E) proteins were suitably modified for immunising MHC class II (MHCII) DNA-genotyped Aotus monkeys and matched with HLA-DRβ1* molecu…
View article: Plasmodium falciparum Blood Stage Antimalarial Vaccines: An Analysis of Ongoing Clinical Trials and New Perspectives Related to Synthetic Vaccines
Plasmodium falciparum Blood Stage Antimalarial Vaccines: An Analysis of Ongoing Clinical Trials and New Perspectives Related to Synthetic Vaccines Open
Plasmodium falciparum malaria is a disease causing high morbidity and mortality rates worldwide, mainly in sub-Saharan Africa. Candidates have been identified for vaccines targeting the parasite's blood stage; this stage is important in th…