Anoma Nellore
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View article: Coordinated circulating and tissue-based T cell responses precede xenograft rejection
Coordinated circulating and tissue-based T cell responses precede xenograft rejection Open
Despite the life-saving successes of solid organ transplantation, the number of individuals needing organ transplant far exceeds the number of organs available for use each year. Porcine xenotransplantation, or the use of pig organs for tr…
View article: Analysis of diagnostic criteria for ECMO-associated pneumonia
Analysis of diagnostic criteria for ECMO-associated pneumonia Open
Ventilator-associated pneumonia (VAP) is a well-established cause of morbidity in critically ill patients. Current VAP criteria exclude patients on extracorporeal membrane oxygenation (ECMO). This retrospective analysis tests the validity …
View article: Association between Respiratory Virus Infection and Development of De Novo Donor-Specific Antibody in Lung Transplant Recipients
Association between Respiratory Virus Infection and Development of De Novo Donor-Specific Antibody in Lung Transplant Recipients Open
Chronic lung allograft dysfunction (CLAD) is the most common cause of long-term lung allograft failure. Several factors, including respiratory virus infection (RVI), have been associated with CLAD development, but the underlying mechanisms…
View article: T-bet+ B Cells in Humans: Protective and Pathologic Functions
T-bet+ B Cells in Humans: Protective and Pathologic Functions Open
The humoral immune system comprises B cells and plasma cells, which play important roles in organ transplantation, ranging from the production of both protective and injurious antibodies as well as cytokines that can promote operational to…
View article: 2420. Analysis of Diagnostic Criteria for ECMO-Associated Pneumonia
2420. Analysis of Diagnostic Criteria for ECMO-Associated Pneumonia Open
Background Ventilator-associated pneumonia (VAP) is a well-established cause of morbidity and mortality in critically ill patients, but diagnostic criteria exclude patients on extracorporeal membrane oxygenation (ECMO). Despite this, VAP h…
View article: Recommendations on prevention of infections during chimeric antigen receptor <scp>T</scp>‐cell and bispecific antibody therapy in multiple myeloma
Recommendations on prevention of infections during chimeric antigen receptor <span>T</span>‐cell and bispecific antibody therapy in multiple myeloma Open
Summary Chimeric antigen receptor T (CAR T) cell and bispecific antibody therapies have shown unprecedented efficacy in heavily pretreated patients with multiple myeloma (MM). However, their use is associated with a significant risk of sev…
View article: Molecular characterization of influenza-specific memory B cell subsets residing in human tissues
Molecular characterization of influenza-specific memory B cell subsets residing in human tissues Open
B cells can be divided into distinct subsets based on origin, activation history and functional attributes. Most human studies, which have characterized bulk polyclonal populations of circulating B cells, suggest heterogeneity between the …
View article: Low Molecular Weight Hyaluronan Inhibits Lung Epithelial Ion Channels by Activating the Calcium-Sensing Receptor
Low Molecular Weight Hyaluronan Inhibits Lung Epithelial Ion Channels by Activating the Calcium-Sensing Receptor Open
Herein, we tested the hypothesis low molecular weight hyaluronan (LMW-HA) inhibits lung epithelial ion transport in-vivo, ex-vivo, and in-vitro by activating the calcium-sensing receptor (CaSR). Intranasal instillation of LMW-HA (150μg/ml)…
View article: COVID-19 Vaccination and Remdesivir are Associated With Protection From New or Increased Levels of Donor-Specific Antibodies Among Kidney Transplant Recipients Hospitalized With COVID-19
COVID-19 Vaccination and Remdesivir are Associated With Protection From New or Increased Levels of Donor-Specific Antibodies Among Kidney Transplant Recipients Hospitalized With COVID-19 Open
Alloimmune responses in kidney transplant (KT) patients previously hospitalized with COVID-19 are understudied. We analyzed a cohort of 112 kidney transplant recipients who were hospitalized following a positive SARS-CoV-2 test result duri…
View article: Daptomycin-Resistant <i>Enterococcus</i> Bacteremia Is Associated With Prior Daptomycin Use and Increased Mortality After Liver Transplantation
Daptomycin-Resistant <i>Enterococcus</i> Bacteremia Is Associated With Prior Daptomycin Use and Increased Mortality After Liver Transplantation Open
Background Risk factors for acquisition of vancomycin-resistant Enterococcus (VRE) include immunosuppression, antibiotic exposure, indwelling catheters, and manipulation of the gastrointestinal tract, all of which occur in liver transplant…
View article: 310. Cryptococcal Infection Following COVID-19 infection in Solid Organ Transplant Recipients: A Case Series
310. Cryptococcal Infection Following COVID-19 infection in Solid Organ Transplant Recipients: A Case Series Open
Background Fungal infections have been identified with or following SARS-CoV-2 infection, most commonly COVID associated pulmonary aspergillosis. Cryptococcus species are ubiquitous in the environment and the third most common invasive fun…
View article: Memory B Cells in Pregnancy Sensitization
Memory B Cells in Pregnancy Sensitization Open
Memory B cells play an important role in immunity to pathogens as these cells are poised to rapidly differentiate into antibody-secreting cells upon antigen re-encounter. Memory B cells also develop over the course of HLA-sensitization dur…
View article: IFNγ induces epigenetic programming of human T-bethi B cells and promotes TLR7/8 and IL-21 induced differentiation
IFNγ induces epigenetic programming of human T-bethi B cells and promotes TLR7/8 and IL-21 induced differentiation Open
Although B cells expressing the IFNγR or the IFNγ-inducible transcription factor T-bet promote autoimmunity in Systemic Lupus Erythematosus (SLE)-prone mouse models, the role for IFNγ signaling in human antibody responses is unknown. We sh…
View article: IFNγ induces epigenetic programming of human T-bet<sup>hi</sup>B cells and promotes TLR7/8 and IL-21 induced differentiation
IFNγ induces epigenetic programming of human T-bet<sup>hi</sup>B cells and promotes TLR7/8 and IL-21 induced differentiation Open
Although B cells expressing the IFNγR or the IFNγ-inducible transcription factor T-bet drive autoimmunity in Systemic Lupus Erythematosus (SLE)-prone mouse models, the role for IFNγ signaling in human antibody responses is unknown. We show…
View article: Moving Career Development Upstream: Evaluation of a Course for Internal Medicine Trainees Contemplating Career Pathways in Academic Medicine
Moving Career Development Upstream: Evaluation of a Course for Internal Medicine Trainees Contemplating Career Pathways in Academic Medicine Open
Pathways is an important educational innovation that gives participants experiences to jumpstart successful careers in academic medicine. We hope that our program will serve as an example for other institutions interested in improving the …
View article: <i>Rhodococcus</i>Infection in Solid Organ and Hematopoietic Stem Cell Transplant Recipients1
<i>Rhodococcus</i>Infection in Solid Organ and Hematopoietic Stem Cell Transplant Recipients1 Open
We conducted a case-control study of 18 US transplant recipients with Rhodococcus infection and 36 matched controls. The predominant types of infection were pneumonia and bacteremia. Diabetes mellitus and recent opportunistic infection wer…
View article: Narcolepsy and influenza vaccination—the inappropriate awakening of immunity
Narcolepsy and influenza vaccination—the inappropriate awakening of immunity Open
Narcolepsy is a chronic neurological disorder characterized by an inability to regulate sleep/wake cycles leading to abruptly occurring periods of daytime sleepiness, cataplexy, hypnogogic hallucinations and disrupted nocturnal sleep (1).