Anran Liu
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View article: Mediterranean diet and associated metabolite signatures in relation to MASLD progression: A prospective cohort study
Mediterranean diet and associated metabolite signatures in relation to MASLD progression: A prospective cohort study Open
Background: Mediterranean diet (MED) is recommended for managing metabolic dysfunction–associated steatotic liver disease (MASLD). However, associations between MED adherence, related metabolite signatures, and risks of liver-related event…
View article: Potential targets of microglia in the treatment of neurodegenerative diseases: Mechanism and therapeutic implications
Potential targets of microglia in the treatment of neurodegenerative diseases: Mechanism and therapeutic implications Open
For diverse neurodegenerative disorders, microglial cells are activated. Furthermore, dysfunctional and hyperactivated microglia initiate mitochondrial autophagy, oxidative stress, and pathological protein accumulation, ending with neuroin…
View article: Research Progress on Pathogenesis and Drug Therapy of Atopic Dermatitis in Children
Research Progress on Pathogenesis and Drug Therapy of Atopic Dermatitis in Children Open
Children with atopic dermatitis (AD) are a chronic inflammatory skin disease with obvious itching symptoms and high recurrence rate in clinical practice. Under the clinical research of atopic dermatitis in children, the clinical treatment …
View article: Metabolite Signatures and Their Mediation Effects on the Relationship Between Mediterranean Diet Adherence and MASLD Progression
Metabolite Signatures and Their Mediation Effects on the Relationship Between Mediterranean Diet Adherence and MASLD Progression Open
Background Mediterranean Diet (MED) is recommended for managing patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). However, the potential metabolic changes involved in this relationship remain unclear. This stu…
View article: Magnetic Molecular Imprinted Polymers-Based Nanozyme for Specific Colorimetric Detection of Protocatechuic Acid
Magnetic Molecular Imprinted Polymers-Based Nanozyme for Specific Colorimetric Detection of Protocatechuic Acid Open
Magnetic molecular imprinted polymers nanozyme MIPs@Fe3O4-NH2 with high specificity and excellent peroxidase-like activity was prepared for colorimetric detection of protocatechuic acid (PCA). Firstly, MIPs@Fe3O4-NH2 was obtained by self-p…
View article: Body composition and risk of liver cancer: a population-based prospective cohort study on gender difference
Body composition and risk of liver cancer: a population-based prospective cohort study on gender difference Open
Background Obesity is a common and highly convincing risk factor for many cancers, including liver cancer. Sex disparities in the body composition and regulatory mechanisms involved in energy homeostasis may contribute to the difference in…
View article: Multimodal Data Integration to Predict Severe Acute Oral Mucositis of Nasopharyngeal Carcinoma Patients Following Radiation Therapy
Multimodal Data Integration to Predict Severe Acute Oral Mucositis of Nasopharyngeal Carcinoma Patients Following Radiation Therapy Open
(1) Background: Acute oral mucositis is the most common side effect for nasopharyngeal carcinoma patients receiving radiotherapy. Improper or delayed intervention to severe AOM could degrade the quality of life or survival for NPC patients…
View article: Artemisinin Alleviates Cerebral Ischemia/Reperfusion‐Induced Oxidative Damage via Regulating PHB2‐Mediated Autophagy in the Human Neuroblastoma SH‐SY5Y Cell Line
Artemisinin Alleviates Cerebral Ischemia/Reperfusion‐Induced Oxidative Damage via Regulating PHB2‐Mediated Autophagy in the Human Neuroblastoma SH‐SY5Y Cell Line Open
Oxidative stress plays a key role in cerebral ischemia/reperfusion injury. Artemisinin (ART) has antioxidative stress activity in addition to its powerful antimalarial effects. In this article, we investigated the effect of ART on OGD/R‐in…
View article: Associations between Visual Acuity and Cognitive Decline in Older Adulthood: A 9-Year Longitudinal Study
Associations between Visual Acuity and Cognitive Decline in Older Adulthood: A 9-Year Longitudinal Study Open
Objective: Emerging evidence suggests low vision may be a modifiable risk factor for cognitive decline. We examined effects of baseline visual acuity (VA) on level of, and change in, cognitive test performance over 9 years. Method: A popul…
View article: Efficacy and Safety of Rotigotine Transdermal Patch on Neuropsychiatric Symptoms of Parkinson's Disease: An Updated Meta-Analysis and Systematic Review
Efficacy and Safety of Rotigotine Transdermal Patch on Neuropsychiatric Symptoms of Parkinson's Disease: An Updated Meta-Analysis and Systematic Review Open
Objective: The effects of rotigotine transdermal patch (RTG) on the neuropsychiatric symptoms of Parkinson's disease (PD) outcomes remain controversial. The aim of this review was to determine the efficacy and safety of RTG on the neuropsy…
View article: Identification of Potential Core Genes and Potential Drugs in Vestibular Schwannoma
Identification of Potential Core Genes and Potential Drugs in Vestibular Schwannoma Open
Vestibular schwannoma is a common intracranial benign tumor, but the current drug treatment effect is not obvious. Surgical treatment can usually lead to residual problems such as nerve damage. Therefore, there is no clear molecular target…
View article: Pharmacological Interventions for REM Sleep Behavior Disorder in Parkinson's Disease: A Systematic Review
Pharmacological Interventions for REM Sleep Behavior Disorder in Parkinson's Disease: A Systematic Review Open
To review the therapeutic effects of drugs on REM sleep behavior disorder (RBD) in Parkinson's disease (PD) by searching the MEDLINE/PubMed, Embase, Cochrane, and CBM databases. According to the inclusion and exclusion criteria, studies we…
View article: Artemisinin attenuated oxidative stress and apoptosis by inhibiting autophagy in MPP+-treated SH-SY5Y cell
Artemisinin attenuated oxidative stress and apoptosis by inhibiting autophagy in MPP+-treated SH-SY5Y cell Open
Background Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. The oxidative stress is an important component of the pathogenesis of PD. Artemisinin (ART) have antioxidant and neuroprotec…
View article: Atorvastatin improves motor function, anxiety and depression by NOX2-mediated autophagy and oxidative stress in MPTP-lesioned mice
Atorvastatin improves motor function, anxiety and depression by NOX2-mediated autophagy and oxidative stress in MPTP-lesioned mice Open
Parkinson's disease (PD) is a neurodegenerative disease caused by the loss of dopaminergic neurons. It is characterized by static tremors, stiffness, slow movements, and gait disturbances, but it is also accompanied by anxiety and depressi…
View article: Exercise and the Risk of Mild Cognitive Impairment
Exercise and the Risk of Mild Cognitive Impairment Open
Introduction: Although exercise is associated with a lower risk for mild cognitive impairment (MCI), it is unclear whether its protective effect depends on the presence or absence of vascular factors. Methods: In an exploratory study of da…
View article: Atorvastatin Alleviates Behavioral Symptoms in MPTP-lesioned Mice: Associated With NOX2-mediated Autophagy and Oxidative Stress
Atorvastatin Alleviates Behavioral Symptoms in MPTP-lesioned Mice: Associated With NOX2-mediated Autophagy and Oxidative Stress Open
Background Parkinson’s disease (PD) is a neurodegenerative disease caused by the loss of dopaminergic neurons. It is characterized by static tremors, stiffness, slow movements, and gait disturbances, but it is also accompanied by anxiety a…
View article: Metabolic syndrome and risk of pancreatic cancer: A population‐based prospective cohort study
Metabolic syndrome and risk of pancreatic cancer: A population‐based prospective cohort study Open
Metabolic syndrome (MetS) and its components may link to pancreatic cancer risk; however, current epidemiological evidence is limited, and the potential mechanisms underlying the associations remain unclear. To investigate this, we carried…
View article: Nur77 attenuates inflammatory responses and oxidative stress by inhibiting phosphorylated IκB-α in Parkinson’s disease cell model
Nur77 attenuates inflammatory responses and oxidative stress by inhibiting phosphorylated IκB-α in Parkinson’s disease cell model Open
Neuroinflammation and oxidative stress play key roles in the pathological development of Parkinson's disease (PD). Nerve growth factor-induced gene B (Nur77) is closely related to dopamine neurotransmission, and its pathogenesis is unclear…