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View article: Variation in Microbiome Composition and Faecal Metabolites Are Associated With Differential Susceptibility to <scp>DSS</scp> ‐Induced Colitis
Variation in Microbiome Composition and Faecal Metabolites Are Associated With Differential Susceptibility to <span>DSS</span> ‐Induced Colitis Open
Variation in microbiome composition is linked to differences in intestinal immune phenotypes and can be leveraged to identify microbiome‐driven contributions to phenotypes of interest. Furthermore, such variation has been associated with d…
View article: Diet modulates Vibrio cholerae colonization and competitive outcomes with the gut microbiota
Diet modulates Vibrio cholerae colonization and competitive outcomes with the gut microbiota Open
The amount or type of dietary macronutrients dramatically changes the microbiota and physicochemical environment of the gut. Because the microbiota plays key roles in pathogen susceptibility, macronutrients could impact infection outcomes.…
View article: Native metabolomics identifies pteridines as CutA ligands and modulators of copper binding
Native metabolomics identifies pteridines as CutA ligands and modulators of copper binding Open
CutA, a conserved protein across all domains of life, has been suggested to be involved in copper tolerance in bacteria, though recent studies have questioned this association, leaving its biological role unknown. To clarify its function, …
View article: Music exposure enhances resistance to <i>Salmonella</i> infection by promoting healthy gut microbiota
Music exposure enhances resistance to <i>Salmonella</i> infection by promoting healthy gut microbiota Open
Music intervention is gaining recognition as a cost-effective therapeutic for improving human health. Despite its growing application, the mechanisms through which music exerts beneficial health effects remain largely unexplored. Here, we …
View article: Maternal probiotic supplementation protects against PBDE-induced developmental, behavior and metabolic reprogramming in a sexually dimorphic manner: Role of gut microbiome
Maternal probiotic supplementation protects against PBDE-induced developmental, behavior and metabolic reprogramming in a sexually dimorphic manner: Role of gut microbiome Open
Polybrominated diphenyl ethers (PBDEs) are endocrine-disrupting persistent organic pollutants (POPs) used as flame retardants in a wide range of commercial applications. We have previously reported neurobehavioral and metabolic reprogrammi…
View article: Diet high in linoleic acid dysregulates the intestinal endocannabinoid system and increases susceptibility to colitis in Mice
Diet high in linoleic acid dysregulates the intestinal endocannabinoid system and increases susceptibility to colitis in Mice Open
Inflammatory bowel disease (IBD) is a multifactorial disease with increasing incidence in the U.S. suggesting that environmental factors, including diet, are involved. It has been suggested that excessive consumption of linoleic acid (LA, …
View article: Microbiome induced complement synthesized in the gut protects against enteric infections
Microbiome induced complement synthesized in the gut protects against enteric infections Open
Canonically, complement is a serum-based host defense system that protects against systemic microbial invasion. Little is known about the production and function of complement components on mucosal surfaces. Here we show gut complement com…
View article: The Native Microbial Community of Gastropod-Associated Phasmarhabditis Species Across Central and Southern California
The Native Microbial Community of Gastropod-Associated Phasmarhabditis Species Across Central and Southern California Open
Nematodes in the genus Phasmarhabditis can infect and kill slugs and snails, which are important agricultural pests. This useful trait has been commercialized by the corporation BASF after they mass produced a product labeled Nemaslug®. Th…
View article: S-Nitrosylation of the virulence regulator AphB promotes Vibrio cholerae pathogenesis
S-Nitrosylation of the virulence regulator AphB promotes Vibrio cholerae pathogenesis Open
Vibrio cholerae is the etiologic agent of the severe human diarrheal disease cholera. To colonize mammalian hosts, this pathogen must defend against host-derived toxic compounds, such as nitric oxide (NO) and NO-derived reactive nitrogen s…
View article: Oral antibiotics reduce voluntary exercise behavior in athletic mice
Oral antibiotics reduce voluntary exercise behavior in athletic mice Open
The gut microbiome can affect various aspects of both behavior and physiology, including exercise ability, but effects on voluntary exercise have rarely been studied. We studied females from a selection experiment in which 4 replicate High…
View article: Microbiota-Associated Biofilm Regulation Leads to Vibrio cholerae Resistance Against Intestinal Environmental Stress
Microbiota-Associated Biofilm Regulation Leads to Vibrio cholerae Resistance Against Intestinal Environmental Stress Open
The commensal microbes of the gut microbiota make important contributions to host defense against gastrointestinal pathogens, including Vibrio cholerae , the etiologic agent of cholera. As interindividual microbiota variation drives indivi…
View article: A commensal-encoded genotoxin drives restriction of <i>Vibrio cholerae</i> colonization and host gut microbiome remodeling
A commensal-encoded genotoxin drives restriction of <i>Vibrio cholerae</i> colonization and host gut microbiome remodeling Open
Significance In a polymicrobial battlefield where different species compete for nutrients and colonization niches, antimicrobial compounds are the sword and shield of commensal microbes in competition with invading pathogens and each other…
View article: Thiol-based functional mimicry of phosphorylation of the two-component system response regulator ArcA promotes pathogenesis in enteric pathogens
Thiol-based functional mimicry of phosphorylation of the two-component system response regulator ArcA promotes pathogenesis in enteric pathogens Open
Pathogenic bacteria can rapidly respond to stresses such as reactive oxygen species (ROS) using reversible redox-sensitive oxidation of cysteine thiol (-SH) groups in regulators. Here, we use proteomics to profile reversible ROS-induced th…
View article: Persistent exercise fatigue and associative learning deficits in combination with transient glucose dyshomeostasis in a mouse model of Gulf War Illness
Persistent exercise fatigue and associative learning deficits in combination with transient glucose dyshomeostasis in a mouse model of Gulf War Illness Open
Our findings demonstrate that GW chemicals dose-dependently determine the presentation of exercise fatigue and severity/type of cognitive/mood-deficient phenotypes that show persistence. Our comprehensive mouse model of GWI recapitulates t…
View article: Diet High in Soybean Oil Increases Susceptibility to Colitis in Mice
Diet High in Soybean Oil Increases Susceptibility to Colitis in Mice Open
SUMMARY The current American diet is high in soybean oil (SO), which consists of unsaturated fatty acids, most notably linoleic acid (LA, C18:2 omega-6). While LA is an essential fatty acid that must be obtained from the diet, high LA cons…
View article: The Interface of <i>Vibrio cholerae</i> and the Gut Microbiome
The Interface of <i>Vibrio cholerae</i> and the Gut Microbiome Open
The bacterium Vibrio cholerae is the etiologic agent of the severe human diarrheal disease cholera. The gut microbiome, or the native community of microorganisms found in the human gastrointestinal tract, is increasingly being recognized a…
View article: Pathogenicity and virulence regulation of <i>Vibrio cholerae</i> at the interface of host-gut microbiome interactions
Pathogenicity and virulence regulation of <i>Vibrio cholerae</i> at the interface of host-gut microbiome interactions Open
The Gram-negative bacterium Vibrio cholerae is responsible for the severe diarrheal pandemic disease cholera, representing a major global public health concern. This pathogen transitions from aquatic reservoirs into epidemics in human popu…
View article: The autoimmune susceptibility gene, <i>PTPN2</i> , restricts expansion of a novel mouse adherent-invasive <i>E. coli</i>
The autoimmune susceptibility gene, <i>PTPN2</i> , restricts expansion of a novel mouse adherent-invasive <i>E. coli</i> Open
Inflammatory bowel disease (IBD) pathogenesis involves significant contributions from genetic and environmental factors. Loss-of-function single-nucleotide polymorphisms (SNPs) in the protein tyrosine phosphatase non-receptor type 2 (PTPN2…
View article: High Levels of Oxidative Stress Create a Microenvironment That Significantly Decreases the Diversity of the Microbiota in Diabetic Chronic Wounds and Promotes Biofilm Formation
High Levels of Oxidative Stress Create a Microenvironment That Significantly Decreases the Diversity of the Microbiota in Diabetic Chronic Wounds and Promotes Biofilm Formation Open
Diabetics chronic wounds are characterized by high levels of oxidative stress (OS) and are often colonized by biofilm-forming bacteria that severely compromise healing and can result in amputation. However, little is known about the role o…
View article: Infection with novel<i>Bacteroides phage BV01</i>alters host transcriptome and bile acid metabolism in a common human gut microbe
Infection with novel<i>Bacteroides phage BV01</i>alters host transcriptome and bile acid metabolism in a common human gut microbe Open
The bacterial genus Bacteroides is among the most abundant and common taxa in the human gut, yet little is known about the phages infecting the group. Bacteroides phage BV01 (BV01) was identified as a prophage integrated on the chromosome …
View article: A Dysbiotic Gut Microbiome Suppresses Antibody Mediated-Protection Against<i>Vibrio cholerae</i>
A Dysbiotic Gut Microbiome Suppresses Antibody Mediated-Protection Against<i>Vibrio cholerae</i> Open
Vibrio cholerae is the etiologic agent of cholera, a severe diarrheal disease that represents a significant burden on global health and productivity. Despite the pressing need, available preventative measures such as oral cholera vaccines …