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View article: Systematic characterization of existing and novel inducible transgenic systems in human pluripotent stem cells after prolonged differentiation
Systematic characterization of existing and novel inducible transgenic systems in human pluripotent stem cells after prolonged differentiation Open
SUMMARY The ability to control transgene expression both temporally and quantitatively in human-relevant cells and tissues is a cornerstone of biomedical research. Additionally, precise transgene control is crucial for optimizing human cel…
View article: Proliferation-competent Tcf1+ CD8 T cells in dysfunctional populations are CD4 T cell help independent
Proliferation-competent Tcf1+ CD8 T cells in dysfunctional populations are CD4 T cell help independent Open
T cell maintenance in chronic infection and cancer follows a hierarchical order. Short-lived effector CD8 T cells are constitutively replaced from a proliferation-competent Tcf1-expressing progenitor population. This occurs spontaneously a…