Anthony Bouter
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View article: Cancer cells transfer invasive properties through microRNAs contained in collagen tracks
Cancer cells transfer invasive properties through microRNAs contained in collagen tracks Open
Invasion is a prerequisite for metastasis formation. During tumor development, type I collagen overexpression increases tumor microenvironment stiffness, facilitating cancer cell dissemination. During breast cancer cell migration in 2D and…
View article: Duchenne muscular dystrophy is driven by defective membrane repair and annexin-A2 dysregulation in skeletal muscle
Duchenne muscular dystrophy is driven by defective membrane repair and annexin-A2 dysregulation in skeletal muscle Open
Background: Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene, which encodes dystrophin in skeletal muscle cells. Although the role of dystrophin as a structural protein is well known, the cellular processes underlyi…
View article: A Novel Assay Reveals the Early Setting‐Up of Membrane Repair Machinery in Human Skeletal Muscle Cells
A Novel Assay Reveals the Early Setting‐Up of Membrane Repair Machinery in Human Skeletal Muscle Cells Open
Defect in membrane repair contributes to the development of muscular dystrophies such as limb girdle muscular dystrophy (LGMD) type R2 or R12. Nevertheless, many other muscular dystrophies may also result from a defect in this process. Ide…
View article: Cancer cells transfer invasive properties through collagen-tracks
Cancer cells transfer invasive properties through collagen-tracks Open
Invasion and migration through the extracellular matrix are prerequisites for metastasis, the leading cause of cancer-related deaths. During tumor development, the extracellular matrix is remodeled, including by overexpressing type I colla…
View article: Annexin‐A5 and annexin‐A6 silencing prevents metastasis of breast cancer cells in zebrafish
Annexin‐A5 and annexin‐A6 silencing prevents metastasis of breast cancer cells in zebrafish Open
Background Information During tumor invasion and metastasis processes, cancer cells are exposed to major compressive and shearing forces, due to their migration through extracellular matrix, dense cell areas, and complex fluids, which may …
View article: Inhibition of the membrane repair protein annexin-A2 prevents tumour invasion and metastasis
Inhibition of the membrane repair protein annexin-A2 prevents tumour invasion and metastasis Open
Cancer cells are exposed to major compressive and shearing forces during invasion and metastasis, leading to extensive plasma membrane damage. To survive this mechanical stress, they need to repair membrane injury efficiently. Targeting th…
View article: Cancer cells transfer invasive properties through tracks, a novel collagen-associated extracellular vesicle entity
Cancer cells transfer invasive properties through tracks, a novel collagen-associated extracellular vesicle entity Open
Metastasis is the leading cause of cancer-related deaths. During this process, tumor cells acquire invasive and migratory capacities in order to invade the surrounding tissues. To achieve this, the tumor microenvironment including the extr…
View article: Trafficking of Annexins during Membrane Repair in Human Skeletal Muscle Cells
Trafficking of Annexins during Membrane Repair in Human Skeletal Muscle Cells Open
Defects in membrane repair contribute to the development of muscular dystrophies, such as Miyoshi muscular dystrophy 1, limb girdle muscular dystrophy (LGMD), type R2 or R12. Deciphering membrane repair dysfunctions in the development of m…
View article: Annexins and Membrane Repair Dysfunctions in Muscular Dystrophies
Annexins and Membrane Repair Dysfunctions in Muscular Dystrophies Open
Muscular dystrophies constitute a group of genetic disorders that cause weakness and progressive loss of skeletal muscle mass. Among them, Miyoshi muscular dystrophy 1 (MMD1), limb girdle muscular dystrophy type R2 (LGMDR2/2B), and LGMDR12…
View article: The CoViBE: An Innovating Self-Paced Elearning to Teach Virtually Bench-Top Practice
The CoViBE: An Innovating Self-Paced Elearning to Teach Virtually Bench-Top Practice Open
COVID-19 pandemic is a disaster and prolonged crisis that has disrupted the education of millions of students with the closure of schools and universities in world-wide. This hard situation rises the necessity to develop a new teaching met…
View article: Annexin-A6 in Membrane Repair of Human Skeletal Muscle Cell: A Role in the Cap Subdomain
Annexin-A6 in Membrane Repair of Human Skeletal Muscle Cell: A Role in the Cap Subdomain Open
Defects in membrane repair contribute to the development of some muscular dystrophies, highlighting the importance to decipher the membrane repair mechanisms in human skeletal muscle. In murine myofibers, the formation of a cap subdomain c…
View article: Defective membrane repair machinery impairs survival of invasive cancer cells
Defective membrane repair machinery impairs survival of invasive cancer cells Open
Cancer cells are able to reach distant tissues by migration and invasion processes. Enhanced ability to cope with physical stresses leading to cell membrane damages may offer to cancer cells high survival rate during metastasis. Consequent…
View article: The unprecedented membrane deformation of the human nuclear envelope, in a magnetic field, indicates formation of nuclear membrane invaginations
The unprecedented membrane deformation of the human nuclear envelope, in a magnetic field, indicates formation of nuclear membrane invaginations Open
Human nuclear membrane (hNM) invaginations are thought to be crucial in fusion, fission and remodeling of cells and present in many human diseases. There is however little knowledge, if any, about their lipid composition and dynamics. We t…