Anthony C. Liang
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View article: Conserved CD8 T cell vaccines without B cell epitopes drive robust protection against SARS-CoV-2 that is enhanced by intranasal boost
Conserved CD8 T cell vaccines without B cell epitopes drive robust protection against SARS-CoV-2 that is enhanced by intranasal boost Open
The emergence of SARS-CoV-2 variants has challenged the current spike protein–focused COVID-19 vaccine strategy due to neutralizing antibody escape and waning antibody-mediated immunity. In contrast, T cell–mediated immunity targeting cons…
View article: Adjuvant-free intranasal T cell vaccine enhances protective mucosal immunity against SARS-CoV-2 3397
Adjuvant-free intranasal T cell vaccine enhances protective mucosal immunity against SARS-CoV-2 3397 Open
Description The emergence of SARS-CoV-2 variants, such as Omicron, has challenged current spike protein-based COVID-19 vaccines due to antibody evasion and waning immunity. T cell-mediated immunity, characterized by durability and the abil…
View article: Aneuploidy generates enhanced nucleotide dependency and sensitivity to metabolic perturbation
Aneuploidy generates enhanced nucleotide dependency and sensitivity to metabolic perturbation Open
Despite the general detriment of aneuploidy to cellular fitness, >90% of solid tumors carry an imbalanced karyotype. This existing paradox and the molecular responses to aneuploidy remain poorly understood. Here, we explore these cellular …
View article: An aneuploidy epistasis map reveals metabolic vulnerabilities associated with supernumerary chromosomes in cancer
An aneuploidy epistasis map reveals metabolic vulnerabilities associated with supernumerary chromosomes in cancer Open
Despite the general detriment of aneuploidy to cellular fitness, >90% of solid tumors carry an imbalanced karyotype. Regardless of this existing paradox, our understanding of the molecular responses to aneuploidy remains limited. Here, we …
View article: Identification of MYC synthetic lethal genes and networks
Identification of MYC synthetic lethal genes and networks Open
SUMMARY MYC is a potent oncogene that is frequently overexpressed in human tumors arising in different tissues. To date there are no approved therapies to directly antagonize oncogenic MYC and its role in driving tumorigenesis. As an alter…
View article: A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells
A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells Open
The GATA4 transcription factor acts as a master regulator of development of multiple tissues. GATA4 also acts in a distinct capacity to control a stress-inducible pro-inflammatory secretory program that is associated with senescence, a pot…
View article: Gain-of-function genetic screening identifies the antiviral function of TMEM120A via STING activation
Gain-of-function genetic screening identifies the antiviral function of TMEM120A via STING activation Open
Zika virus (ZIKV) infection can be associated with neurological pathologies, such as microcephaly in newborns and Guillain-Barre syndrome in adults. Effective therapeutics are currently not available. As such, a comprehensive understanding…
View article: K63-linked polyubiquitin chains bind to DNA to facilitate DNA damage repair
K63-linked polyubiquitin chains bind to DNA to facilitate DNA damage repair Open
Mutations in the DNA-interacting patch of ubiquitin sensitize cells to DNA-damaging agents.