Anthony Cutts
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View article: Circulating tumour DNA to augment PET-CT in determining clinical outcome after head and neck cancer treatment
Circulating tumour DNA to augment PET-CT in determining clinical outcome after head and neck cancer treatment Open
LB outperformed PET-CT at determining true disease status after CRT and could complement post-treatment imaging in CRT and surgical patients, playing a potential role in decision-making after treatment.
View article: Clinical Validation of Liquid Biopsy for Faster Molecular Diagnosis of EBV-Positive Burkitt Lymphoma
Clinical Validation of Liquid Biopsy for Faster Molecular Diagnosis of EBV-Positive Burkitt Lymphoma Open
Burkitt Lymphoma (BL) is common in sub-Saharan Africa, but its diagnosis is often delayed. Here, we comprehensively evaluate blood-based liquid biopsies from 377 children and young adults with clinically suspected lymphoma for diagnostic a…
View article: Multimodal cell-free DNA whole-genome TAPS is sensitive and reveals specific cancer signals
Multimodal cell-free DNA whole-genome TAPS is sensitive and reveals specific cancer signals Open
The analysis of circulating tumour DNA (ctDNA) through minimally invasive liquid biopsies is promising for early multi-cancer detection and monitoring minimal residual disease. Most existing methods focus on targeted deep sequencing, but f…
View article: Targeted Next-Generation Sequencing of Cell-Free DNA to Detect <i>MYC</i> -Immunoglobulin Translocation and Epstein-Barr Virus DNA in Plasma of Burkitt Lymphoma Patients in East Africa
Targeted Next-Generation Sequencing of Cell-Free DNA to Detect <i>MYC</i> -Immunoglobulin Translocation and Epstein-Barr Virus DNA in Plasma of Burkitt Lymphoma Patients in East Africa Open
PURPOSE Epstein-Barr virus (EBV)–positive Burkitt lymphoma (BL) affects children in sub-Saharan Africa, but diagnosis via tissue biopsy is challenging. We explored a liquid biopsy approach using targeted next-generation sequencing to detec…
View article: Performance of a Liquid Biopsy Diagnostic Prediction Model for EBV-Positive Burkitt Lymphoma in Sub-Saharan Africa
Performance of a Liquid Biopsy Diagnostic Prediction Model for EBV-Positive Burkitt Lymphoma in Sub-Saharan Africa Open
Burkitt Lymphoma (BL) is classified into EBV-positive BL (EBL) and EBV-negative BL (sporadic BL), the former being more prevalent in SSA (Al-Khreisat et al 2023). Conventional diagnosis of BL depends on the morphological assessment of inva…
View article: Multimodal cell-free DNA whole-genome analysis combined with TET-Assisted Pyridine Borane Sequencing is sensitive and reveals specific cancer signals
Multimodal cell-free DNA whole-genome analysis combined with TET-Assisted Pyridine Borane Sequencing is sensitive and reveals specific cancer signals Open
The analysis of circulating tumour DNA (ctDNA) promises to extend current tissue-specific cancer screening programmes to multi-cancer early detection and measurable disease monitoring to solid tumours using minimally invasive blood draws (…
View article: A statistical approach for tracking clonal dynamics in cancer using longitudinal next-generation sequencing data
A statistical approach for tracking clonal dynamics in cancer using longitudinal next-generation sequencing data Open
Motivation Tumours are composed of distinct cancer cell populations (clones), which continuously adapt to their local micro-environment. Standard methods for clonal deconvolution seek to identify groups of mutations and estimate the preval…
View article: A statistical approach for tracking clonal dynamics in cancer using longitudinal next-generation sequencing data
A statistical approach for tracking clonal dynamics in cancer using longitudinal next-generation sequencing data Open
Tumours are composed of genotypically and phenotypically distinct cancer cell populations ( clones ), which are subject to a process of Darwinian evolution in response to changes in their local micro-environment, such as drug treatment. In…
View article: Dual-specificity protein phosphatase DUSP4 regulates response to MEK inhibition in BRAF wild-type melanoma
Dual-specificity protein phosphatase DUSP4 regulates response to MEK inhibition in BRAF wild-type melanoma Open
Background Aiming to improve treatment options for BRAF wild-type melanoma, we previously conducted the DOC-MEK study of docetaxel with MEK inhibitor (MEKi) selumetinib or placebo, revealing trends to prolongation of progression-free survi…
View article: A method for noninvasive prenatal diagnosis of monogenic autosomal recessive disorders
A method for noninvasive prenatal diagnosis of monogenic autosomal recessive disorders Open
Using sickle cell disease as a model, Cutts et al describe a highly sensitive method for prenatal diagnosis of known single-gene defects using next-generation sequencing of maternal plasma cell-free DNA.
View article: A method for non-invasive prenatal diagnosis of monogenic autosomal recessive disorders
A method for non-invasive prenatal diagnosis of monogenic autosomal recessive disorders Open
Non-invasive prenatal testing (NIPT) to date is used in the clinic primarily to detect foetal aneuploidy. Few studies so far have focused on the detection of monogenic autosomal recessive disorders where mother and foetus carry the same mu…
View article: Identifying somatic mutations in cell‐free <scp>DNA</scp> of aggressive lymphoma patients: First cell‐free <scp>DNA</scp> results from the molecular profiling for lymphoma (<scp>MaPLe</scp>) study
Identifying somatic mutations in cell‐free <span>DNA</span> of aggressive lymphoma patients: First cell‐free <span>DNA</span> results from the molecular profiling for lymphoma (<span>MaPLe</span>) study Open
Introduction: Capturing the genomic landscape of a cancer located in multiple anatomical sites from a single biopsy is complicated by intertumour and intratumour heterogeneity. Recent work in solid tumours suggests that analysis of cell-fr…
View article: Clinical applicability and cost of a 46-gene panel for genomic analysis of solid tumours: Retrospective validation and prospective audit in the UK National Health Service
Clinical applicability and cost of a 46-gene panel for genomic analysis of solid tumours: Retrospective validation and prospective audit in the UK National Health Service Open
This study demonstrates that more extensive tumour sequencing can identify mutations that could improve clinical decision-making in routine cancer care, potentially improving patient outcomes, at an affordable level for healthcare provider…
View article: Targeted Next-Generation Sequencing of Plasma DNA from Cancer Patients: Factors Influencing Consistency with Tumour DNA and Prospective Investigation of Its Utility for Diagnosis
Targeted Next-Generation Sequencing of Plasma DNA from Cancer Patients: Factors Influencing Consistency with Tumour DNA and Prospective Investigation of Its Utility for Diagnosis Open
Use of circulating tumour DNA (ctDNA) as a liquid biopsy has been proposed for potential identification and monitoring of solid tumours. We investigate a next-generation sequencing approach for mutation detection in ctDNA in two related st…