Anthony D. Ho
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View article: Accumulation of Lymphoid Progenitors with Defective B Cell Differentiation and of Putative Natural Killer Progenitors in Aging Human Bone Marrow
Accumulation of Lymphoid Progenitors with Defective B Cell Differentiation and of Putative Natural Killer Progenitors in Aging Human Bone Marrow Open
In animal models, elimination of the senescent cells in the hematopoietic stem cells (HSCs) compartment leads to the rejuvenation of hematopoiesis. Whether this treatment principle can be applied to the human system remains controversial. …
View article: High-throughput DNA melt measurements enable improved models of DNA folding thermodynamics
High-throughput DNA melt measurements enable improved models of DNA folding thermodynamics Open
DNA folding thermodynamics are central to many biological processes and biotechnological applications involving base-pairing. Current methods for predicting stability from DNA sequence use nearest-neighbor models that struggle to accuratel…
View article: A Senescent Cluster in Aged Human Hematopoietic Stem Cell Compartment as Target for Senotherapy
A Senescent Cluster in Aged Human Hematopoietic Stem Cell Compartment as Target for Senotherapy Open
To identify the differences between aged and young human hematopoiesis, we performed a direct comparison of aged and young human hematopoietic stem and progenitor cells (HSPCs). Alterations in transcriptome profiles upon aging between huma…
View article: Cell-type-specific consequences of mosaic structural variants in hematopoietic stem and progenitor cells
Cell-type-specific consequences of mosaic structural variants in hematopoietic stem and progenitor cells Open
The functional impact and cellular context of mosaic structural variants (mSVs) in normal tissues is understudied. Utilizing Strand-seq, we sequenced 1,133 single-cell genomes from 19 human donors of increasing age, and discovered the hete…
View article: High-Throughput DNA melt measurements enable improved models of DNA folding thermodynamics
High-Throughput DNA melt measurements enable improved models of DNA folding thermodynamics Open
DNA folding thermodynamics are central to many biological processes and biotechnological applications involving base-pairing. Current methods for predicting stability from DNA sequence use nearest-neighbor models that struggle to accuratel…
View article: Reversible Host–Guest Crosslinks in Supramolecular Hydrogels for On‐Demand Mechanical Stimulation of Human Mesenchymal Stem Cells
Reversible Host–Guest Crosslinks in Supramolecular Hydrogels for On‐Demand Mechanical Stimulation of Human Mesenchymal Stem Cells Open
Stem cells are regulated not only by biochemical signals but also by biophysical properties of extracellular matrix (ECM). The ECM is constantly monitored and remodeled because the fate of stem cells can be misdirected when the mechanical …
View article: Cell type-specific consequences of mosaic structural variants in hematopoietic stem and progenitor cells
Cell type-specific consequences of mosaic structural variants in hematopoietic stem and progenitor cells Open
The functional impact and cellular context of mosaic structural variants (mSVs) in normal tissues is understudied. Utilizing Strand-seq, we sequenced 1,133 single cell genomes from 19 human donors of increasing age, revealing a heterogeneo…
View article: Bio‐Metamaterials for Mechano‐Regulation of Mesenchymal Stem Cells
Bio‐Metamaterials for Mechano‐Regulation of Mesenchymal Stem Cells Open
Cell behaviors significantly depend on the elastic properties of the microenvironments, which are distinct from commonly used polymer‐based substrates. Artificial elastic materials called metamaterials offer large freedom to adjust their e…
View article: Data from Targeting the BRAF V600E Mutation in Multiple Myeloma
Data from Targeting the BRAF V600E Mutation in Multiple Myeloma Open
In multiple myeloma, there has been little progress in the specific therapeutic targeting of oncogenic mutations. Whole-genome sequencing data have recently revealed that a subset of patients carry an activating mutation (V600E) in the BRA…
View article: Supplementary Table 1 from Targeting the BRAF V600E Mutation in Multiple Myeloma
Supplementary Table 1 from Targeting the BRAF V600E Mutation in Multiple Myeloma Open
PDF file - 54K, Detailed clinical course of all BRAF-mutated patients.
View article: Data from Targeting the BRAF V600E Mutation in Multiple Myeloma
Data from Targeting the BRAF V600E Mutation in Multiple Myeloma Open
In multiple myeloma, there has been little progress in the specific therapeutic targeting of oncogenic mutations. Whole-genome sequencing data have recently revealed that a subset of patients carry an activating mutation (V600E) in the BRA…
View article: Supplementary Table 1 from Targeting the BRAF V600E Mutation in Multiple Myeloma
Supplementary Table 1 from Targeting the BRAF V600E Mutation in Multiple Myeloma Open
PDF file - 54K, Detailed clinical course of all BRAF-mutated patients.
View article: Supplementary Methods and Materials from Identification of Griseofulvin as an Inhibitor of Centrosomal Clustering in a Phenotype-Based Screen
Supplementary Methods and Materials from Identification of Griseofulvin as an Inhibitor of Centrosomal Clustering in a Phenotype-Based Screen Open
Supplementary Methods and Materials from Identification of Griseofulvin as an Inhibitor of Centrosomal Clustering in a Phenotype-Based Screen
View article: Supplementary Figure 1 from GF-15, a Novel Inhibitor of Centrosomal Clustering, Suppresses Tumor Cell Growth <i>In Vitro</i> and <i>In Vivo</i>
Supplementary Figure 1 from GF-15, a Novel Inhibitor of Centrosomal Clustering, Suppresses Tumor Cell Growth <i>In Vitro</i> and <i>In Vivo</i> Open
PDF file - 60K, GF-15 does not induce spindle multipolarity in resistant cells
View article: Supplementary Table 1 from Identification of Griseofulvin as an Inhibitor of Centrosomal Clustering in a Phenotype-Based Screen
Supplementary Table 1 from Identification of Griseofulvin as an Inhibitor of Centrosomal Clustering in a Phenotype-Based Screen Open
Supplementary Table 1 from Identification of Griseofulvin as an Inhibitor of Centrosomal Clustering in a Phenotype-Based Screen
View article: Supplemental Figure 3 from Cell Division Patterns in Acute Myeloid Leukemia Stem-like Cells Determine Clinical Course: A Model to Predict Patient Survival
Supplemental Figure 3 from Cell Division Patterns in Acute Myeloid Leukemia Stem-like Cells Determine Clinical Course: A Model to Predict Patient Survival Open
Supplemental Figure 3. The figure compares estimated LSC properties in first and second relapse of 4 patients.
View article: Supplementary Figure Legends 1-5 from GF-15, a Novel Inhibitor of Centrosomal Clustering, Suppresses Tumor Cell Growth <i>In Vitro</i> and <i>In Vivo</i>
Supplementary Figure Legends 1-5 from GF-15, a Novel Inhibitor of Centrosomal Clustering, Suppresses Tumor Cell Growth <i>In Vitro</i> and <i>In Vivo</i> Open
PDF file - 50K
View article: Supplementary Figure 2 from Identification of Griseofulvin as an Inhibitor of Centrosomal Clustering in a Phenotype-Based Screen
Supplementary Figure 2 from Identification of Griseofulvin as an Inhibitor of Centrosomal Clustering in a Phenotype-Based Screen Open
Supplementary Figure 2 from Identification of Griseofulvin as an Inhibitor of Centrosomal Clustering in a Phenotype-Based Screen
View article: Supplementary Figure 4 from Identification of Griseofulvin as an Inhibitor of Centrosomal Clustering in a Phenotype-Based Screen
Supplementary Figure 4 from Identification of Griseofulvin as an Inhibitor of Centrosomal Clustering in a Phenotype-Based Screen Open
Supplementary Figure 4 from Identification of Griseofulvin as an Inhibitor of Centrosomal Clustering in a Phenotype-Based Screen
View article: Supplementary Figure 6 from Identification of Griseofulvin as an Inhibitor of Centrosomal Clustering in a Phenotype-Based Screen
Supplementary Figure 6 from Identification of Griseofulvin as an Inhibitor of Centrosomal Clustering in a Phenotype-Based Screen Open
Supplementary Figure 6 from Identification of Griseofulvin as an Inhibitor of Centrosomal Clustering in a Phenotype-Based Screen
View article: Supplemental Methods from Cell Division Patterns in Acute Myeloid Leukemia Stem-like Cells Determine Clinical Course: A Model to Predict Patient Survival
Supplemental Methods from Cell Division Patterns in Acute Myeloid Leukemia Stem-like Cells Determine Clinical Course: A Model to Predict Patient Survival Open
Supplemental Methods. Detailed derivation and calibration of mathematical model.
View article: Supplemental Figure 2 from Cell Division Patterns in Acute Myeloid Leukemia Stem-like Cells Determine Clinical Course: A Model to Predict Patient Survival
Supplemental Figure 2 from Cell Division Patterns in Acute Myeloid Leukemia Stem-like Cells Determine Clinical Course: A Model to Predict Patient Survival Open
Supplemental Figure 2. The figure depicts estimated LSC properties for the subgroup of FLT3-ITD (a typical leukemogenetic mutation) positive patients.
View article: Supplementary Figure Legends 1-5 from GF-15, a Novel Inhibitor of Centrosomal Clustering, Suppresses Tumor Cell Growth <i>In Vitro</i> and <i>In Vivo</i>
Supplementary Figure Legends 1-5 from GF-15, a Novel Inhibitor of Centrosomal Clustering, Suppresses Tumor Cell Growth <i>In Vitro</i> and <i>In Vivo</i> Open
PDF file - 50K
View article: Supplementary Figure 2 from Identification of Griseofulvin as an Inhibitor of Centrosomal Clustering in a Phenotype-Based Screen
Supplementary Figure 2 from Identification of Griseofulvin as an Inhibitor of Centrosomal Clustering in a Phenotype-Based Screen Open
Supplementary Figure 2 from Identification of Griseofulvin as an Inhibitor of Centrosomal Clustering in a Phenotype-Based Screen
View article: Supplementary Figure 1 from Identification of Griseofulvin as an Inhibitor of Centrosomal Clustering in a Phenotype-Based Screen
Supplementary Figure 1 from Identification of Griseofulvin as an Inhibitor of Centrosomal Clustering in a Phenotype-Based Screen Open
Supplementary Figure 1 from Identification of Griseofulvin as an Inhibitor of Centrosomal Clustering in a Phenotype-Based Screen
View article: Supplemental Figure 1 from Cell Division Patterns in Acute Myeloid Leukemia Stem-like Cells Determine Clinical Course: A Model to Predict Patient Survival
Supplemental Figure 1 from Cell Division Patterns in Acute Myeloid Leukemia Stem-like Cells Determine Clinical Course: A Model to Predict Patient Survival Open
Supplemental Figure 1. The figure depicts fit of model to individual patients' marrow blast counts.
View article: Supplementary Figure 4 from Identification of Griseofulvin as an Inhibitor of Centrosomal Clustering in a Phenotype-Based Screen
Supplementary Figure 4 from Identification of Griseofulvin as an Inhibitor of Centrosomal Clustering in a Phenotype-Based Screen Open
Supplementary Figure 4 from Identification of Griseofulvin as an Inhibitor of Centrosomal Clustering in a Phenotype-Based Screen