Anthony J. Day
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View article: The hyaluronan receptor CD44 drives COVID-19 severity through its regulation of neutrophil migration
The hyaluronan receptor CD44 drives COVID-19 severity through its regulation of neutrophil migration Open
The novel respiratory disease COVID-19 caused by the coronavirus SARS-CoV-2 continues to be a public health emergency worldwide, and there is a need for more effective therapy for patients. The relationship between the extracellular matrix…
View article: Generation of a Ym1 deficient mouse utilising CRISPR-Cas9 in CB6 embryos
Generation of a Ym1 deficient mouse utilising CRISPR-Cas9 in CB6 embryos Open
Chitinase-like proteins (CLPs) are of wide interest due to their significant roles during both homeostatic and pathological processes. Human CLPs such as YKL-40 have been proposed as biomarkers of disease severity in many conditions. Murin…
View article: Molecular determinants of extracellular TIMP-3 accumulation in Sorsby fundus dystrophy
Molecular determinants of extracellular TIMP-3 accumulation in Sorsby fundus dystrophy Open
Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a critical regulator of extracellular matrix turnover. Mutations in TIMP-3 cause Sorsby fundus dystrophy (SFD), an inherited macular dystrophy that is similar to age-related macular dege…
View article: The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-α-inhibitor regulate crosslinking of the hyaluronan matrix
The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-α-inhibitor regulate crosslinking of the hyaluronan matrix Open
View article: Hyaluronan in COVID-19: a matrix for understanding lung disease
Hyaluronan in COVID-19: a matrix for understanding lung disease Open
The polysaccharide hyaluronan (HA) is an important component of lung extracellular matrix that increases following infection with influenza or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Hellman et al. (U. Hellman, E. Ros…
View article: Evidence of an Allostatic Response by Intestinal Tissues Following Induction of Joint Inflammation
Evidence of an Allostatic Response by Intestinal Tissues Following Induction of Joint Inflammation Open
Disrupted intestinal epithelial barrier function has been proposed to be integral to rheumatoid arthritis (RA) progression and pathogenesis. To further define the molecular pathways in synovial inflammation and the response of the intestin…
View article: Injury From Nematode Lung Migration Induces an IL‐13‐Dependent Hyaluronan Matrix
Injury From Nematode Lung Migration Induces an IL‐13‐Dependent Hyaluronan Matrix Open
A consistent feature of lung injury is a rapid and sustained accumulation of hyaluronan (HA). The rodent gut‐dwelling nematode Nippostrongylus brasiliensis (Nb) induces tissue damage as it migrates through the lungs. Type 2 immune response…
View article: Hyaluronan‐protein interactions: Lilliput revisited
Hyaluronan‐protein interactions: Lilliput revisited Open
Hyaluronan (HA) is a huge linear polysaccharide composed entirely of a simple repeating disaccharide that has been preserved unchanged since the evolution of vertebrates ~520 million years ago. It is present in all mammalian tissues, being…
View article: The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-α-inhibitor regulate crosslinking of the hyaluronan matrix
The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-α-inhibitor regulate crosslinking of the hyaluronan matrix Open
Pentraxin-3 (PTX3) is an octameric protein, comprised of eight identical protomers, that has diverse functions in reproductive biology, innate immunity and cancer. PTX3 interacts with the large polysaccharide hyaluronan (HA) to which heavy…
View article: Chemical modification of hyaluronan oligosaccharides differentially modulates hyaluronan–hyaladherin interactions
Chemical modification of hyaluronan oligosaccharides differentially modulates hyaluronan–hyaladherin interactions Open
The glycosaminoglycan hyaluronan (HA) is a ubiquitous, nonsulfated polysaccharide with diverse biological roles mediated through its interactions with HA-binding proteins (HABPs). Most HABPs belong to the Link module superfamily, including…
View article: A novel method to quantify TSG‐6 protein levels in synovial fluid from osteoarthritis patients
A novel method to quantify TSG‐6 protein levels in synovial fluid from osteoarthritis patients Open
TSG‐6, the protein product of Tumor Necrosis Factor‐stimulated gene‐6, is a potential biomarker of disease activity/progression in osteoarthritis (OA). By ELISA, TSG‐6 is elevated in synovial fluid (SF) from OA patients and its catalytic a…
View article: Chemical modification of hyaluronan oligosaccharides differentially modulates hyaluronan- hyaladherin interactions
Chemical modification of hyaluronan oligosaccharides differentially modulates hyaluronan- hyaladherin interactions Open
The glycosaminoglycan hyaluronan (HA) is a ubiquitous, non-sulphated polysaccharide with diverse biological roles mediated through its interactions with HA-binding proteins (HABPs). Most HABPs belong to the Link module superfamily, includi…
View article: Reading Javanese Literature with Questions of Theory in Mind
Reading Javanese Literature with Questions of Theory in Mind Open
View article: Targeted Analysis of the Size Distribution of Heavy Chain-Modified Hyaluronan with Solid-State Nanopores
Targeted Analysis of the Size Distribution of Heavy Chain-Modified Hyaluronan with Solid-State Nanopores Open
The glycosaminoglycan hyaluronan (HA) plays important roles in diverse physiological functions where the distribution of its molecular weight (MW) can influence its behavior and is known to change in response to disease conditions. During …
View article: V3: an enigmatic isoform of the proteoglycan versican
V3: an enigmatic isoform of the proteoglycan versican Open
V3 is an isoform of the extracellular matrix (ECM) proteoglycan (PG) versican generated through alternative splicing of the versican gene such that the two major exons coding for sequences in the protein core that support chondroitin sulfa…
View article: The recombinant Link module of human TSG-6 suppresses cartilage damage in models of osteoarthritis: A potential disease-modifying OA drug
The recombinant Link module of human TSG-6 suppresses cartilage damage in models of osteoarthritis: A potential disease-modifying OA drug Open
Link_TSG6 has enhanced chondroprotective activity compared to the full-length TSG-6 protein and shows potential as a disease modifying OA drug via its inhibition of aggrecanase and collagenase activity.
View article: Variant Hyprocrea jecorina CBH1 cellulases
Variant Hyprocrea jecorina CBH1 cellulases Open
Described herein are variants of H. jecorina CBH I, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability and reversibility.
View article: Variant Hypocrea jercorina CBH1 cellulases
Variant Hypocrea jercorina CBH1 cellulases Open
Described herein are variants of H. jecorina CBH I, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability and reversibility.
View article: Variant Hypocrea jecorina CBH1 cellulases
Variant Hypocrea jecorina CBH1 cellulases Open
Described herein are variants of H. jecorina CBH I, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability and reversibility.
View article: Variant Hypocrea jecorina CBH1 cellulase
Variant Hypocrea jecorina CBH1 cellulase Open
Described herein are variants of H. jecorina CBH I, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability and reversibility.
View article: Dysfunctional Extracellular Matrix Remodeling Supports Perianal Fistulizing Crohn′s Disease by a Mechanoregulated Activation of the Epithelial-to-Mesenchymal Transition
Dysfunctional Extracellular Matrix Remodeling Supports Perianal Fistulizing Crohn′s Disease by a Mechanoregulated Activation of the Epithelial-to-Mesenchymal Transition Open
By mediating changes in the ECM organization, TSG-6 triggers the epithelial-mesenchymal transition transcription factor SNAI1 through the activation of mechanosensitive proteins. These data point to regulators of ECM as new potential targe…
View article: Disease modification and symptom relief in osteoarthritis using a mutated <scp>GCP</scp> ‐2/ <scp>CXCL6</scp> chemokine
Disease modification and symptom relief in osteoarthritis using a mutated <span>GCP</span> ‐2/ <span>CXCL6</span> chemokine Open
We showed that the chemokine receptor C-X-C Motif Chemokine Receptor 2 (CXCR2) is essential for cartilage homeostasis. Here, we reveal that the CXCR2 ligand granulocyte chemotactic protein 2 (GCP-2) was expressed, during embryonic developm…
View article: Mast cell infiltration of the choroid and protease release are early events in age-related macular degeneration associated with genetic risk at both chromosomes 1q32 and 10q26
Mast cell infiltration of the choroid and protease release are early events in age-related macular degeneration associated with genetic risk at both chromosomes 1q32 and 10q26 Open
Significance Genome-wide association studies have identified two major risk loci for age-related macular degeneration (AMD) on chromosome (Chr) 1 and Chr10. Here, we use proteomics to analyze submacular stromal tissue punches from older ey…
View article: Referee report. For: The Ring Fencing Mechanism: a case study of innovative self-financing approach for energy efficiency upgrades [version 1; peer review: 1 approved with reservations]
Referee report. For: The Ring Fencing Mechanism: a case study of innovative self-financing approach for energy efficiency upgrades [version 1; peer review: 1 approved with reservations] Open
View article: The Link module of human TSG-6 (Link_TSG6) promotes wound healing, suppresses inflammation and improves glandular function in mouse models of Dry Eye Disease
The Link module of human TSG-6 (Link_TSG6) promotes wound healing, suppresses inflammation and improves glandular function in mouse models of Dry Eye Disease Open
Link_TSG6 holds promise as a novel therapeutic agent for DED through its effects on the promotion of corneal epithelial healing and tear secretion, the preservation of conjunctival goblet cells and the suppression of inflammation.
View article: IL-13 is a driver of COVID-19 severity
IL-13 is a driver of COVID-19 severity Open
Immune dysregulation is characteristic of the more severe stages of SARS-CoV-2 infection. Understanding the mechanisms by which the immune system contributes to COVID-19 severity may open new avenues to treatment. Here, we report that elev…
View article: A Personal Tribute to Robert B. Sim with Reflections on Our Work Together on Factor H
A Personal Tribute to Robert B. Sim with Reflections on Our Work Together on Factor H Open
Robert (Bob) Sim had a profound effect on almost every aspect of my approach to scientific research, acting as a mentor and moral compass through the many different stages of my career [...]
View article: The recombinant Link module of human TSG-6 suppresses cartilage damage in models of osteoarthritis: a potential disease-modifying OA drug
The recombinant Link module of human TSG-6 suppresses cartilage damage in models of osteoarthritis: a potential disease-modifying OA drug Open
Objectives To investigate the role of endogenous TSG-6 in human osteoarthritis (OA) and assess the disease-modifying potential of a TSG-6-based biological treatment in cell, explant and animal models of OA. Methods Knee articular cartilage…
View article: Dataset related to article "Control of Complement Activation by the Long Pentraxin PTX3: Implications in Age-Related Macular Degeneration"
Dataset related to article "Control of Complement Activation by the Long Pentraxin PTX3: Implications in Age-Related Macular Degeneration" Open
This record contains data related to article "Control of Complement Activation by the Long Pentraxin PTX3: Implications in Age-Related Macular Degeneration" Abstract. Dysregulation of the complement system is central to ag…
View article: Dataset related to article "Control of Complement Activation by the Long Pentraxin PTX3: Implications in Age-Related Macular Degeneration"
Dataset related to article "Control of Complement Activation by the Long Pentraxin PTX3: Implications in Age-Related Macular Degeneration" Open
This record contains data related to article "Control of Complement Activation by the Long Pentraxin PTX3: Implications in Age-Related Macular Degeneration" Abstract. Dysregulation of the complement system is central to ag…