Anthony J. Intorcia
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View article: Safe autopsy procedures for COVID-19: Experience of one research center
Safe autopsy procedures for COVID-19: Experience of one research center Open
In the early days of the 2019 coronavirus disease (COVID-19) pandemic, there were few published guidelines for safely performing autopsies of infected individuals. To limit the risk to autopsy personnel, major changes to our autopsy protoc…
View article: Safe Autopsy Procedures for COVID-19: Experience of One Research Center
Safe Autopsy Procedures for COVID-19: Experience of One Research Center Open
In the early days of the 2019 coronavirus disease (COVID-19) pandemic, there were few published guidelines for safely performing autopsies of infected individuals. The limited information relied on assumptions that the risks would be simil…
View article: Characterization of Isolated Human Astrocytes from Aging Brain
Characterization of Isolated Human Astrocytes from Aging Brain Open
Astrocytes have multiple crucial roles, including maintaining brain homeostasis and synaptic function, performing phagocytic clearance, and responding to injury and repair. It has been suggested that astrocyte performance is progressively …
View article: Characterization of isolated human astrocytes from aging brain
Characterization of isolated human astrocytes from aging brain Open
Astrocytes have multiple crucial roles, including maintaining brain homeostasis and synaptic function, performing phagocytic clearance and responding to injury and repair. It has been suggested that astrocyte performance is progressively i…
View article: Transcriptional characterization of relaxin‐3‐positive neurons in aging and Alzheimer’s disease
Transcriptional characterization of relaxin‐3‐positive neurons in aging and Alzheimer’s disease Open
Background Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder worldwide and is characterized by clinical symptoms that include deficits in memory and cognition. There is an urgent need to better identify the neural n…
View article: Unveiling a novel memory center in human brain: neurochemical identification of the nucleus incertus, a key pontine locus implicated in stress and neuropathology
Unveiling a novel memory center in human brain: neurochemical identification of the nucleus incertus, a key pontine locus implicated in stress and neuropathology Open
View article: RNA sequencing of olfactory bulb in Parkinson's disease reveals gene alterations associated with olfactory dysfunction
RNA sequencing of olfactory bulb in Parkinson's disease reveals gene alterations associated with olfactory dysfunction Open
The olfactory bulb is involved early in the pathophysiology of Parkinson's disease (PD), which is consistent with the early onset of olfactory dysfunction. Identifying the molecular mechanisms through which PD affects the olfactory bulb co…
View article: Identification of diffusion, kurtosis, and propagator MRI markers of Alzheimer’s disease pathology in post-mortem human tissue
Identification of diffusion, kurtosis, and propagator MRI markers of Alzheimer’s disease pathology in post-mortem human tissue Open
Alzheimer’s disease (AD) is an irreversible degenerative brain disease affecting 6.7 million Americans and while the hallmark AD pathologies of plaques and tangles follow a stereotyped progression during the course of the disease, clinical…
View article: Correlation of Presynaptic and Postsynaptic Proteins with Pathology in Alzheimer’s Disease
Correlation of Presynaptic and Postsynaptic Proteins with Pathology in Alzheimer’s Disease Open
Synaptic transmission is essential for nervous system function and the loss of synapses is a known major contributor to dementia. Alzheimer’s disease dementia (ADD) is characterized by synaptic loss in the mesial temporal lobe and cerebral…
View article: Correlation of Presynaptic and Postsynaptic Proteins with Pathology in Alzheimer’s Disease
Correlation of Presynaptic and Postsynaptic Proteins with Pathology in Alzheimer’s Disease Open
Synaptic transmission is essential for nervous system function and the loss of synapses is a known major contributor to dementia. Alzheimer’s disease dementia (ADD) is characterized by synaptic loss in the mesial temporal lobe and ce…
View article: The Human Brain Nucleus Incertus: A New Target in Dementia?
The Human Brain Nucleus Incertus: A New Target in Dementia? Open
Background The brainstem nucleus incertus (NI) or ‘uncertain nucleus’, was originally described by Streeter in 1903 as a midline region in the floor of the fourth ventricle of the human brain with an ‘unknown’ function. A century later, th…
View article: THE INTERPLAY OF NEUROPEPTIDES IN SHAPING NEURONAL ACTIVITY – OXYTOCIN AND RELAXIN-3 IN THE CONTROL OF HIPPOCAMPUS DENTATE GYRUS ACTIVITY – HUMAN AND RAT STUDIES
THE INTERPLAY OF NEUROPEPTIDES IN SHAPING NEURONAL ACTIVITY – OXYTOCIN AND RELAXIN-3 IN THE CONTROL OF HIPPOCAMPUS DENTATE GYRUS ACTIVITY – HUMAN AND RAT STUDIES Open
View article: A NEW PLAYER IN CONTROL OF VENTRAL HIPPOCAMPUS ACTIVITY; RELAXIN-3/RXFP3 SIGNALING AND RELAXIN-3 INNERVATION OF VENTRAL HIPPOCAMPUS DENTATE GYRUS - HUMAN AND RAT STUDIES
A NEW PLAYER IN CONTROL OF VENTRAL HIPPOCAMPUS ACTIVITY; RELAXIN-3/RXFP3 SIGNALING AND RELAXIN-3 INNERVATION OF VENTRAL HIPPOCAMPUS DENTATE GYRUS - HUMAN AND RAT STUDIES Open
View article: Unveiling a Novel Memory Center in Humans: Neurochemical Identification of the<i>Nucleus Incertus</i>, a Key Pontine Locus Implicated in Stress and Neuropathology
Unveiling a Novel Memory Center in Humans: Neurochemical Identification of the<i>Nucleus Incertus</i>, a Key Pontine Locus Implicated in Stress and Neuropathology Open
Background The nucleus incertus (NI) was originally described by Streeter in 1903, as a midline region in the floor of the fourth ventricle (4V) of the human brain with an ‘unknown’ function. More than a century later, the neuroanatomy of …
View article: Measuring Up: A Comparison of TapeStation 4200 and Bioanalyzer 2100 as Measurement Tools for RNA Quality in Postmortem Human Brain Samples
Measuring Up: A Comparison of TapeStation 4200 and Bioanalyzer 2100 as Measurement Tools for RNA Quality in Postmortem Human Brain Samples Open
The determination of RNA integrity is a critical quality assessment tool for gene expression studies where the experiment’s success is highly dependent on the sample quality. Since its introduction in 1999, the gold standard in the scienti…
View article: Measuring up: A Comparison of Tapestation 4200 and Bioanalyzer 2100 as Measurement Tools for RNA Quality in Postmortem Human Brain Samples
Measuring up: A Comparison of Tapestation 4200 and Bioanalyzer 2100 as Measurement Tools for RNA Quality in Postmortem Human Brain Samples Open
Determining RNA integrity is a critical quality assessment tool for gene expression studies where the experiment’s success is highly dependent on sample quality. Since its introduction in 1999, the gold standard in the scientific community…
View article: Cerebral white matter rarefaction has both neurodegenerative and vascular causes and may primarily be a distal axonopathy
Cerebral white matter rarefaction has both neurodegenerative and vascular causes and may primarily be a distal axonopathy Open
Cerebral white matter rarefaction (CWMR) was considered by Binswanger and Alzheimer to be due to cerebral arteriolosclerosis. Renewed attention came with CT and MR brain imaging, and neuropathological studies finding a high rate of CWMR in…
View article: SARS-CoV-2 Brain Regional Detection, Histopathology, Gene Expression, and Immunomodulatory Changes in Decedents with COVID-19
SARS-CoV-2 Brain Regional Detection, Histopathology, Gene Expression, and Immunomodulatory Changes in Decedents with COVID-19 Open
Brains of 42 COVID-19 decedents and 107 non-COVID-19 controls were studied. RT-PCR screening of 16 regions from 20 COVID-19 autopsies found SARS-CoV-2 E gene viral sequences in 7 regions (2.5% of 320 samples), concentrated in 4/20 subjects…
View article: The tau oligomer antibody APNmAb005 detects early-stage pathological tau enriched at synapses and rescues neuronal loss in long-term treatments
The tau oligomer antibody APNmAb005 detects early-stage pathological tau enriched at synapses and rescues neuronal loss in long-term treatments Open
Numerous tau immunotherapies are being developed against Alzheimer’s disease (AD), but it has been challenging to specifically target early-stage tau aggregates using conformation-dependent antibodies. Here, we report a monoclonal antibody…
View article: Olfactory Bulb Amyloid-β Correlates With Brain Thal Amyloid Phase and Severity of Cognitive Impairment
Olfactory Bulb Amyloid-β Correlates With Brain Thal Amyloid Phase and Severity of Cognitive Impairment Open
The Alzheimer disease (AD) neuropathological hallmarks amyloid β (Aβ) and tau neurofibrillary (NF) pathology have been reported in the olfactory bulb (OB) in aging and in different neurodegenerative diseases, which coincides with frequentl…
View article: Effect of olfactory bulb pathology on olfactory function in normal aging
Effect of olfactory bulb pathology on olfactory function in normal aging Open
Decline of olfactory function is frequently observed in aging and is an early symptom of neurodegenerative diseases. As the olfactory bulb (OB) is one of the first regions involved by pathology and may represent an early disease stage, we …
View article: Hemispheric Asymmetry and Atypical Lobar Progression of Alzheimer-Type Tauopathy
Hemispheric Asymmetry and Atypical Lobar Progression of Alzheimer-Type Tauopathy Open
The spread of neurofibrillary tau pathology in Alzheimer disease (AD) mostly follows a stereotypical pattern of topographical progression but atypical patterns associated with interhemispheric asymmetry have been described. Because histopa…
View article: Deafferentation of Olfactory Bulb in Subjects Dying with COVID-19
Deafferentation of Olfactory Bulb in Subjects Dying with COVID-19 Open
There have been clinical descriptions of diverse neurological effects in COVID-19 disease, involving up to 36% of patients. It appears likely that most of these are not caused by viral brain invasion but by systemic accompaniments of criti…
View article: White Matter β-Amyloid Precursor Protein Immunoreactivity in Autopsied Subjects With and Without COVID-19
White Matter β-Amyloid Precursor Protein Immunoreactivity in Autopsied Subjects With and Without COVID-19 Open
The coronavirus SARS-CoV-2 causes COVID-19, a predominantly respiratory disease that has been reported to be associated with numerous neurological signs, symptoms and syndromes. More than 20 published studies have used RT-PCR methods to de…
View article: Olfactory Bulb and Amygdala Gene Expression Changes in Subjects Dying with COVID-19
Olfactory Bulb and Amygdala Gene Expression Changes in Subjects Dying with COVID-19 Open
In this study we conducted RNA sequencing on two brain regions (olfactory bulb and amygdala) from subjects who died from COVID-19 or who died of other causes. We found several-fold more transcriptional changes in the olfactory bulb than in…
View article: Vagus Nerve and Stomach Synucleinopathy in Parkinson’s Disease, Incidental Lewy Body Disease, and Normal Elderly Subjects: Evidence Against the “Body-First” Hypothesis
Vagus Nerve and Stomach Synucleinopathy in Parkinson’s Disease, Incidental Lewy Body Disease, and Normal Elderly Subjects: Evidence Against the “Body-First” Hypothesis Open
Background: Braak and others have proposed that Lewy-type α-synucleinopathy in Parkinson’s disease (PD) may arise from an exogenous pathogen that passes across the gastric mucosa and then is retrogradely transported up the vagus nerve to t…
View article: Acute Brain Ischemia, Infarction and Hemorrhage in Subjects Dying with or Without Autopsy-Proven Acute Pneumonia
Acute Brain Ischemia, Infarction and Hemorrhage in Subjects Dying with or Without Autopsy-Proven Acute Pneumonia Open
Stroke is one of the most serious complications of Covid-19 disease but it is still unclear whether stroke is more common with Covid-19 pneumonia as compared to non-Covid-19 pneumonia. We investigated the concurrence rate of autopsy-confir…
View article: Mapping of SARS-CoV-2 Brain Invasion and Histopathology in COVID-19 Disease
Mapping of SARS-CoV-2 Brain Invasion and Histopathology in COVID-19 Disease Open
The coronavirus SARS-CoV-2 (SCV2) causes acute respiratory distress, termed COVID-19 disease, with substantial morbidity and mortality. As SCV2 is related to previously-studied coronaviruses that have been shown to have the capability for …
View article: Whole-Cell Dissociated Suspension Analysis in Human Brain Neurodegenerative Disease: A Pilot Study
Whole-Cell Dissociated Suspension Analysis in Human Brain Neurodegenerative Disease: A Pilot Study Open
Biochemical analysis of human brain tissue is typically done by homogenizing whole pieces of brain and separately characterizing the proteins, RNA, DNA, and other macromolecules within. While this has been sufficient to identify substantia…
View article: Increased Risk of Autopsy-Proven Pneumonia with Sex, Season and Neurodegenerative Disease
Increased Risk of Autopsy-Proven Pneumonia with Sex, Season and Neurodegenerative Disease Open
There has been a markedly renewed interest in factors associated with pneumonia, a leading cause of death worldwide, due to its frequent concurrence with pandemics of influenza and Covid-19 disease. Reported predisposing factors to both ba…