Xiang Chen
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View article: CanID: A Robust and Accurate RNA-seq Expression-based Diagnostic Classification Scheme for Pediatric Malignancies
CanID: A Robust and Accurate RNA-seq Expression-based Diagnostic Classification Scheme for Pediatric Malignancies Open
Cancer subtype classification is critical for precision therapy and there is a growing trend of augmenting histopathology testing procedures with omics-based machine learning classifiers. However, analytical challenges remain for pediatric…
View article: <i> RPGR <sup>ORF15</sup> </i> Mutations Disrupt Lysosomal Lipid Metabolism in Retinal Pigment Epithelium Cells and Cause Retinitis Pigmentosa
<i> RPGR <sup>ORF15</sup> </i> Mutations Disrupt Lysosomal Lipid Metabolism in Retinal Pigment Epithelium Cells and Cause Retinitis Pigmentosa Open
RPGRORF15 is essential for maintaining lysosome function and lipid metabolism homeostasis in RPE cells. This finding elucidates the previously unrecognized role of RPGRORF15 in RPE cells. This study provides new insights into the mechanism…
View article: CDK4/6 and BET inhibitors synergistically suppress pancreatic tumor growth and epithelial-to-mesenchymal transition by regulating the GSK3β-mediated Wnt/β-catenin pathway
CDK4/6 and BET inhibitors synergistically suppress pancreatic tumor growth and epithelial-to-mesenchymal transition by regulating the GSK3β-mediated Wnt/β-catenin pathway Open
Aim: Cyclin-dependent kinases 4 and 6 (CDK4/6) are frequently upregulated in pancreatic ductal adenocarcinoma (PDAC) and are associated with poor overall survival. Although CDK4/6 inhibition suppresses tumor cell proliferation, it paradoxi…
View article: Targeted Blockage of Pathological Extracellular Vesicles and Particles From Fibroblast‐Like Synoviocytes for Osteoarthritis Relief: Proteomic Analysis and Cellular Effect
Targeted Blockage of Pathological Extracellular Vesicles and Particles From Fibroblast‐Like Synoviocytes for Osteoarthritis Relief: Proteomic Analysis and Cellular Effect Open
Osteoarthritis (OA), the prevalent debilitating joint disorder, is accelerated by dysregulated intercellular crosstalk, yet the role of fibroblast‐like synoviocyte (FLS)‐derived extracellular vesicles and particles (EVPs) in disease progre…
View article: Case report: Secondary neck mass infection in a patient with multiple osteomyelitis caused by Corynebacterium striatum
Case report: Secondary neck mass infection in a patient with multiple osteomyelitis caused by Corynebacterium striatum Open
Rationale: The opportunistic pathogen Corynebacterium striatum has been generating more clinical infections in recent years, but secondary infections at different parts caused by it have been reported more rarely. Patient concerns: This ca…
View article: Seq2Karyotype (S2K): A Method for <i>in-silico</i> Karyotyping Using Single-Sample Whole-Genome Sequencing Data
Seq2Karyotype (S2K): A Method for <i>in-silico</i> Karyotyping Using Single-Sample Whole-Genome Sequencing Data Open
DNA abnormalities characterized by cytogenetic imaging at the single cell resolution, i.e. karyotyping, have long served as cancer diagnostic and prognostic biomarkers. To enable in-silico karyotyping using unpaired whole-genome sequencing…
View article: CanID: a robust and accurate RNAseq Expression-based diagnostic classification scheme for pediatric malignancies
CanID: a robust and accurate RNAseq Expression-based diagnostic classification scheme for pediatric malignancies Open
Cancer subtype classification is critical for precision therapy and there is a growing trend of augmenting histopathology testing procedures with omics-based machine learning classifiers. However, analytical challenges remain for pediatric…
View article: Rsearch progress on the relationship between aging and microbiota in sarcopenia
Rsearch progress on the relationship between aging and microbiota in sarcopenia Open
Sarcopenia is an age-related skeletal muscle disease associated with adverse outcomes such as falls, decreased function, frailty, and death, and is a significant global public health problem that impairs the functioning of individuals. Agi…
View article: High-throughput neurotoxicity study of neonicotinoids in C. elegans: Oxidative stress and serotonergic neuronal damage as key mechanisms
High-throughput neurotoxicity study of neonicotinoids in C. elegans: Oxidative stress and serotonergic neuronal damage as key mechanisms Open
Neonicotinoids (NEOs) have been widely used as effective pesticides for decades, yet their adverse effects on non-target organisms remain a growing concern. Although the neurotoxicity of certain NEOs has been established, the potential neu…
View article: Directional growth of developing myelin mediated by Wnt gradient and required for proper axon functions
Directional growth of developing myelin mediated by Wnt gradient and required for proper axon functions Open
Axon-wrapping myelin sheaths formed by oligodendrocytes are essential for proper functions of the central nervous system. Although much is known about oligodendrocyte development, how the myelin dynamically forms remains unclear. Here we s…
View article: Boron Phenylalanine-Modified Polydopamine Nanoparticles for Targeted Delivery of Danusertib in Non-Small Cell Lung Cancer
Boron Phenylalanine-Modified Polydopamine Nanoparticles for Targeted Delivery of Danusertib in Non-Small Cell Lung Cancer Open
B-PDA@Danu provides a novel nanomedicine approach for anti-NSCLC therapy that enables targeted tumor elimination with low potential toxicity.
View article: In Vitro Examination of Fungal and Root Extracts Inspired by Traditional Medicine for Potential Periorbital Eye Infrastructure Treatments
In Vitro Examination of Fungal and Root Extracts Inspired by Traditional Medicine for Potential Periorbital Eye Infrastructure Treatments Open
An early indicator of aging may appear around the eyes and the surrounding eye infrastructure. With aging, there come diminishing changes in vascular microcirculation and the accumulation of hemoglobin by-products that gather in the fatty …
View article: First-in-human PET imaging and evaluation of melanin-targeted [<sup>18</sup>F]DMPY2 in malignant melanoma patients
First-in-human PET imaging and evaluation of melanin-targeted [<sup>18</sup>F]DMPY2 in malignant melanoma patients Open
Aim: Early diagnosis and accurate malignant melanoma (MM) staging are significant and decisive in clinical practice. [18F]DMPY2 is a promising PET tracer in vivo with high affinity and selectivity for melanin. The study aims to investigate…
View article: Global, regional, and national burden and trends of rheumatoid arthritis among the elderly population: an analysis based on the 2021 Global Burden of Disease study
Global, regional, and national burden and trends of rheumatoid arthritis among the elderly population: an analysis based on the 2021 Global Burden of Disease study Open
Background Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease. In elderly patients, the disease progresses more rapidly, involves more complications, and places a greater burden on health. Currently, there is a lack of stu…
View article: Hyperbaric Oxygen Regulates Tumor pH to Boost Copper‐Doped Hydroxyethyl Starch Conjugate Nanoparticles Against Cancer Stem Cells
Hyperbaric Oxygen Regulates Tumor pH to Boost Copper‐Doped Hydroxyethyl Starch Conjugate Nanoparticles Against Cancer Stem Cells Open
An extracellular acidic environment and an intracellular mildly alkaline environment induced by carbonic anhydrase 9 (CA9) play a critical role in self‐renewal, invasion, migration, and drug resistance of cancer stem cells (CSCs) within hy…
View article: Supplementary Table S1 from Conditional Activation of c-MYC in Distinct Catecholaminergic Cells Drives Development of Neuroblastoma or Somatostatinoma
Supplementary Table S1 from Conditional Activation of c-MYC in Distinct Catecholaminergic Cells Drives Development of Neuroblastoma or Somatostatinoma Open
CSTN tumor metadata
View article: Supplementary Table S4 from Conditional Activation of c-MYC in Distinct Catecholaminergic Cells Drives Development of Neuroblastoma or Somatostatinoma
Supplementary Table S4 from Conditional Activation of c-MYC in Distinct Catecholaminergic Cells Drives Development of Neuroblastoma or Somatostatinoma Open
Differentially expressed genes in c-MYC PNET and c-MYC neuroblastoma
View article: Supplementary Table S5 from Conditional Activation of c-MYC in Distinct Catecholaminergic Cells Drives Development of Neuroblastoma or Somatostatinoma
Supplementary Table S5 from Conditional Activation of c-MYC in Distinct Catecholaminergic Cells Drives Development of Neuroblastoma or Somatostatinoma Open
GSEA results for c-MYC PNET and c-MYC neuroblastoma
View article: Supplementary Data from Conditional Activation of c-MYC in Distinct Catecholaminergic Cells Drives Development of Neuroblastoma or Somatostatinoma
Supplementary Data from Conditional Activation of c-MYC in Distinct Catecholaminergic Cells Drives Development of Neuroblastoma or Somatostatinoma Open
Supplementary Data including 12 figures and table S1
View article: Data from Conditional Activation of c-MYC in Distinct Catecholaminergic Cells Drives Development of Neuroblastoma or Somatostatinoma
Data from Conditional Activation of c-MYC in Distinct Catecholaminergic Cells Drives Development of Neuroblastoma or Somatostatinoma Open
c-MYC is an important driver of high-risk neuroblastoma. A lack of c-MYC–driven genetically engineered mouse models (GEMM) has hampered the ability to better understand mechanisms of neuroblastoma oncogenesis and to develop effective thera…
View article: Supplementary Table S3 from Conditional Activation of c-MYC in Distinct Catecholaminergic Cells Drives Development of Neuroblastoma or Somatostatinoma
Supplementary Table S3 from Conditional Activation of c-MYC in Distinct Catecholaminergic Cells Drives Development of Neuroblastoma or Somatostatinoma Open
Differentially expressed genes in c-MYC- and MYCN-driven neuroblastomas