Anthony Muchai Manyara
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View article: Prevalence and correlates of common mental health disorders, functioning and resilience among youth in Western Kenya. A cross-sectional study
Prevalence and correlates of common mental health disorders, functioning and resilience among youth in Western Kenya. A cross-sectional study Open
Background Mental health disorders are a growing global public health concern. In Kenya, as in many low–and middle–income countries, youth mental health remains underprioritized. In Western Kenya, data on the prevalence and determinants of…
View article: Nutrition Outcomes and Interventions in Older People in Africa: A Systematic Umbrella and Scoping Review
Nutrition Outcomes and Interventions in Older People in Africa: A Systematic Umbrella and Scoping Review Open
Africa’s older population is rapidly increasing, necessitating the development of healthy aging interventions. Nutrition is a key component of healthy aging. Evidence synthesis on nutrition outcomes of older adults in Africa is emerging bu…
View article: Development of START-EDI guidelines for reporting equality, diversity and inclusion in research: a study protocol
Development of START-EDI guidelines for reporting equality, diversity and inclusion in research: a study protocol Open
Introduction Acknowledging equality, diversity and inclusion (EDI) in research is not only a moral imperative but also an important step in avoiding bias and ensuring generalisability of results. This protocol describes the development of …
View article: Measuring wealth in rural and urban Africa: findings and recommendations from a multi-country study
Measuring wealth in rural and urban Africa: findings and recommendations from a multi-country study Open
Wealth indices enable socioeconomic status measurement, particularly in low- and middle-income countries. However, their reliability, validity, and data collection and computation efficiency can be improved. This analysis aimed to generate…
View article: Effect of a cognitive behavioural therapy intervention to improve sleep on food preferences: A randomized controlled trial in adults with overweight and obesity
Effect of a cognitive behavioural therapy intervention to improve sleep on food preferences: A randomized controlled trial in adults with overweight and obesity Open
View article: The need for further guidance on the handling of multiple outcomes in randomized controlled trials: a scoping review of the methodological literature
The need for further guidance on the handling of multiple outcomes in randomized controlled trials: a scoping review of the methodological literature Open
Current recommendations on using MOCs in RCTs focus primarily on statistical considerations and trials of licensing drugs or medical devices. Areas for further methodological research and guidance include reporting of the rationale for the…
View article: Prevalence and Outcomes of Intrinsic Capacity Impairments Assessed Using the WHO Integrated Care for Older People (ICOPE) Framework in Rural and Urban Africa: A Cross-Sectional Study
Prevalence and Outcomes of Intrinsic Capacity Impairments Assessed Using the WHO Integrated Care for Older People (ICOPE) Framework in Rural and Urban Africa: A Cross-Sectional Study Open
View article: Surrogate endpoints in randomised trials of physiotherapy interventions: the SPIRIT and CONSORT extension checklists for better reporting
Surrogate endpoints in randomised trials of physiotherapy interventions: the SPIRIT and CONSORT extension checklists for better reporting Open
View article: Types, design, implementation, and evaluation of nutrition interventions in older people in Africa: A scoping review protocol
Types, design, implementation, and evaluation of nutrition interventions in older people in Africa: A scoping review protocol Open
Introduction Africa’s older population is increasing and this, necessitates the development of interventions to promote healthy ageing. Nutrition is a key determinant of healthy ageing and local contextual evidence is needed to inform nutr…
View article: Prevalence, factors and quality of life associated with frailty and pre‐frailty in middle‐aged and older adults living with <scp>HIV</scp> in Zimbabwe: A cross‐sectional study
Prevalence, factors and quality of life associated with frailty and pre‐frailty in middle‐aged and older adults living with <span>HIV</span> in Zimbabwe: A cross‐sectional study Open
Objectives We investigated associations between HIV, frailty and health‐related quality of life (HRQoL). Methods This cross‐sectional study recruited men and women aged ≥40 years in Zimbabwe. A researcher collected clinical and HRQoL data,…
View article: Sample size in multistakeholder Delphi surveys: at what minimum sample size do replicability of results stabilize?
Sample size in multistakeholder Delphi surveys: at what minimum sample size do replicability of results stabilize? Open
View article: Reporting of surrogate endpoints in randomised controlled trial protocols (SPIRIT-Surrogate): extension checklist with explanation and elaboration
Reporting of surrogate endpoints in randomised controlled trial protocols (SPIRIT-Surrogate): extension checklist with explanation and elaboration Open
Randomised controlled trials often use surrogate endpoints to substitute for a target outcome (an outcome of direct interest and relevance to trial participants, clinicians, and other stakeholders—eg, all cause mortality) to improve effici…
View article: Reporting of surrogate endpoints in randomised controlled trial reports (CONSORT-Surrogate): extension checklist with explanation and elaboration
Reporting of surrogate endpoints in randomised controlled trial reports (CONSORT-Surrogate): extension checklist with explanation and elaboration Open
Randomised controlled trials commonly use surrogate endpoints to substitute for a target outcome (outcome of direct interest and relevance to trial participants, clinicians, and other stakeholders—eg, all cause mortality) to improve their …
View article: Scooping Review of Diabetes Research in Kenya from 2000 to 2020
Scooping Review of Diabetes Research in Kenya from 2000 to 2020 Open
Background: The prevalence of diabetes is on the rise globally, with likely disproportionate increase in Sub-Saharan Africa. In Kenya, diabetes has been acknowledged as one of the top non-communicable diseases needing prevention and contro…
View article: Perceptions of diabetes risk and prevention in Nairobi, Kenya: A qualitative and theory of change development study
Perceptions of diabetes risk and prevention in Nairobi, Kenya: A qualitative and theory of change development study Open
Background Type 2 diabetes is increasing in Kenya, especially in urban settings, and prevention interventions based on local evidence and context are urgently needed. Therefore, this study aimed to explore diabetes risk and co-create a dia…
View article: Knowledge, perceptions and practices towards diabetes risk in sub-Saharan Africa: a mixed-methods scoping review
Knowledge, perceptions and practices towards diabetes risk in sub-Saharan Africa: a mixed-methods scoping review Open
Objective: To synthesise current evidence on knowledge, perceptions and practices towards type 2 diabetes risk in sub-Saharan Africa Design: Mixed-methods scoping review, which included 101 studies (seventy-three quantitative, twenty quali…
View article: Surrogate endpoints: a key concept in clinical epidemiology
Surrogate endpoints: a key concept in clinical epidemiology Open
Surrogate endpoints are biomarkers or intermediate outcomes that are used as substitutes for clinical outcomes of interest, often to expedite research or decision-making. In contrast, patient-important (or patient-centered) outcomes are he…
View article: A framework for the definition and interpretation of the use of surrogate endpoints in interventional trials
A framework for the definition and interpretation of the use of surrogate endpoints in interventional trials Open
SPIRIT-SURROGATE/CONSORT-SURROGATE project is Medical Research Council Better Research Better Health (MR/V038400/1) funded.
View article: Diabetes research in Kenya from 2000 to 2020: A scoping review
Diabetes research in Kenya from 2000 to 2020: A scoping review Open
Background: The prevalence of diabetes is on the rise globally, with likely disproportionate increase in Sub-Saharan Africa. In Kenya, diabetes has been acknowledged as one of the top non-communicable diseases needing prevention and contro…
View article: Table of Contents
Table of Contents Open
View article: Definitions, acceptability, limitations, and guidance in the use and reporting of surrogate end points in trials: a scoping review
Definitions, acceptability, limitations, and guidance in the use and reporting of surrogate end points in trials: a scoping review Open
View article: A Framework for the Definition and Interpretation of the Use of Surrogate Endpoints in Interventional Trials’
A Framework for the Definition and Interpretation of the Use of Surrogate Endpoints in Interventional Trials’ Open
View article: Surrogate endpoints in trials: a call for better reporting
Surrogate endpoints in trials: a call for better reporting Open
View article: Completeness in reporting of surrogate primary endpoints in Randomised Controlled Trials: A targeted review protocol v1
Completeness in reporting of surrogate primary endpoints in Randomised Controlled Trials: A targeted review protocol v1 Open
Introduction Using a surrogate endpoint as a substitute for a patient-relevant final outcome enables randomised controlled trials (RCTs) to be conducted more efficiently. However, there is currently no consensus-driven reporting guideline …
View article: Protocol for the development of SPIRIT and CONSORT extensions for randomised controlled trials with surrogate primary endpoints: SPIRIT-SURROGATE and CONSORT-SURROGATE
Protocol for the development of SPIRIT and CONSORT extensions for randomised controlled trials with surrogate primary endpoints: SPIRIT-SURROGATE and CONSORT-SURROGATE Open
Introduction Randomised controlled trials (RCTs) may use surrogate endpoints as substitutes and predictors of patient-relevant/participant-relevant final outcomes (eg, survival, health-related quality of life). Translation of effects measu…
View article: Scoping and targeted reviews to support development of SPIRIT and CONSORT extensions for randomised controlled trials with surrogate primary endpoints: protocol
Scoping and targeted reviews to support development of SPIRIT and CONSORT extensions for randomised controlled trials with surrogate primary endpoints: protocol Open
Introduction Using a surrogate endpoint as a substitute for a primary patient-relevant outcome enables randomised controlled trials (RCTs) to be conducted more efficiently, that is, with shorter time, smaller sample size and lower cost. Ho…
View article: Surrogate end points in cardio-thoracic trials: a call for better reporting and improved interpretation of trial findings
Surrogate end points in cardio-thoracic trials: a call for better reporting and improved interpretation of trial findings Open
Evidence to inform regulatory, funding and clinical decisions about health interventions should come from well-conducted clinical trials. Despite the challenges associated to their design, conduct and generalizability, randomized controlle…
View article: Surrogate endpoints in trials—a call for better reporting
Surrogate endpoints in trials—a call for better reporting Open
View article: Need for better reporting of trials with surrogate endpoints: SPIRIT|CONSORT-SURROGATE extensions
Need for better reporting of trials with surrogate endpoints: SPIRIT|CONSORT-SURROGATE extensions Open
View article: Research priorities to reduce the impact of COVID-19 in low- and middle-income countries
Research priorities to reduce the impact of COVID-19 in low- and middle-income countries Open
Health policy and systems research to inform COVID-19 vaccine uptake and equitable access to care are urgently needed, especially for rural, vulnerable, and/or marginalised populations. This research should occur in parallel with studies t…