Anthony P. Cardile
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View article: Longitudinal phase 2 clinical trials of live, attenuated tularemia vaccine in healthy research laboratory workers
Longitudinal phase 2 clinical trials of live, attenuated tularemia vaccine in healthy research laboratory workers Open
Background Tularemia is caused by the intracellular bacterium Francisella tularensis ( Ft ). It was weaponized historically due to low infectious aerosol dose, high morbidity, and mortality rates for pneumonic disease. The US Army develope…
View article: Longitudinal phase 2 clinical trials of live, attenuated tularemia vaccine in otherwise healthy research laboratory workers operating in containment laboratories
Longitudinal phase 2 clinical trials of live, attenuated tularemia vaccine in otherwise healthy research laboratory workers operating in containment laboratories Open
Background Tularemia is a bacterial disease caused by the intracellular bacterium Francisella tularensis ( F. tularensis or Ft ). It has been weaponized historically by multiple state actors due to its low infectious aerosol dose, high mor…
View article: Natural History of Aerosol-Induced Ebola Virus Disease in Rhesus Macaques
Natural History of Aerosol-Induced Ebola Virus Disease in Rhesus Macaques Open
Ebola virus disease (EVD) is a serious global health concern because case fatality rates are approximately 50% due to recent widespread outbreaks in Africa. Well-defined nonhuman primate (NHP) models for different routes of Ebola virus exp…
View article: The utilization of advance telemetry to investigate critical physiological parameters including electroencephalography in cynomolgus macaques following aerosol challenge with eastern equine encephalitis virus
The utilization of advance telemetry to investigate critical physiological parameters including electroencephalography in cynomolgus macaques following aerosol challenge with eastern equine encephalitis virus Open
Most alphaviruses are mosquito-borne and can cause severe disease in humans and domesticated animals. In North America, eastern equine encephalitis virus (EEEV) is an important human pathogen with case fatality rates of 30–90%. Currently, …
View article: Safety and immunogenicity of an inactivated eastern equine encephalitis virus vaccine
Safety and immunogenicity of an inactivated eastern equine encephalitis virus vaccine Open
Inactivated PE-6 EEEV vaccine is safe and immunogenic in at-risk laboratory personnel. A prolonged primary series, with month 6 dose, significantly improved vaccine immunogenicity both post-primary series and longitudinally on annual titer…
View article: The Utilization of Advance Telemetry to Investigate Important Physiological Parameters Including Electroencephalography in Cynomolgus Macaques Following Aerosol Challenge with Eastern Equine Encephalitis Virus
The Utilization of Advance Telemetry to Investigate Important Physiological Parameters Including Electroencephalography in Cynomolgus Macaques Following Aerosol Challenge with Eastern Equine Encephalitis Virus Open
Most alphaviruses are mosquito-borne and can cause severe disease in humans and domesticated animals. In North America, eastern equine encephalitis virus (EEEV) is an important human pathogen with case fatality rates of 30-90%. Currently, …
View article: Intensive Care Unit–Like Care of Nonhuman Primates with Ebola Virus Disease
Intensive Care Unit–Like Care of Nonhuman Primates with Ebola Virus Disease Open
Background Ebola virus disease (EVD) supportive care strategies are largely guided by retrospective observational research. This study investigated the effect of EVD supportive care algorithms on duration of survival in a controlled nonhum…
View article: The Western Equine Encephalitis Lyophilized, Inactivated Vaccine: An Update on Safety and Immunogenicity
The Western Equine Encephalitis Lyophilized, Inactivated Vaccine: An Update on Safety and Immunogenicity Open
https://clinicaltrials.gov/, identifier NCT01159561.
View article: Natural History of Aerosol Induced Lassa Fever in Non-Human Primates
Natural History of Aerosol Induced Lassa Fever in Non-Human Primates Open
Lassa virus (LASV), an arenavirus causing Lassa fever, is endemic to West Africa with up to 300,000 cases and between 5000 and 10,000 deaths per year. Rarely seen in the United States, Lassa virus is a CDC category A biological agent inasm…
View article: The Joint Mobile Emerging Disease Clinical Capability (JMEDICC) laboratory approach: Capabilities for high-consequence pathogen clinical research
The Joint Mobile Emerging Disease Clinical Capability (JMEDICC) laboratory approach: Capabilities for high-consequence pathogen clinical research Open
Following the 2013-2016 Ebola virus outbreak in West Africa, numerous groups advocated for the importance of executing clinical trials in outbreak settings. The difficulties associated with obtaining reliable data to support regulatory app…
View article: 411. Does an Early Cytokine Response During Ebola Virus Disease Improve the Duration of Survival in Rhesus Macaques?
411. Does an Early Cytokine Response During Ebola Virus Disease Improve the Duration of Survival in Rhesus Macaques? Open
Background Ebola virus disease results in a severe cytokine release resulting in organ failure and disseminated intravascular coagulation, often leading to death. An early post-exposure immune response may improve outcomes but that remains…
View article: 2773. Safety and Immunogenicity Study of Eastern Equine Encephalitis Vaccine
2773. Safety and Immunogenicity Study of Eastern Equine Encephalitis Vaccine Open
Background Eastern equine encephalitis virus (EEEV) is an alphavirus with a high mortality rate and serious neurological sequelae in infected persons making this virus an important human pathogen. Methods Following written informed consent…
View article: An Emerging Biothreat: Crimean-Congo Hemorrhagic Fever Virus in Southern and Western Asia
An Emerging Biothreat: Crimean-Congo Hemorrhagic Fever Virus in Southern and Western Asia Open
Tick-borne Crimean-Congo hemorrhagic fever virus (CCHFV) is endemic in numerous countries, but the epidemiology and epizoology of Crimean-Congo hemorrhagic fever (CCHF) remain to be defined for most regions of the world. Using a broad data…
View article: Virulence of Marburg Virus Angola Compared to Mt. Elgon (Musoke) in Macaques: A Pooled Survival Analysis
Virulence of Marburg Virus Angola Compared to Mt. Elgon (Musoke) in Macaques: A Pooled Survival Analysis Open
Angola variant (MARV/Ang) has replaced Mt. Elgon variant Musoke isolate (MARV/MtE-Mus) as the consensus standard variant for Marburg virus research and is regarded as causing a more aggressive phenotype of disease in animal models; however…
View article: 2493. Marburg Virus Disease: Virulence of Angola vs. Musoke Strain in Cynomolgus Macaques
2493. Marburg Virus Disease: Virulence of Angola vs. Musoke Strain in Cynomolgus Macaques Open
BACKGROUND: From 2004 to 2005, an outbreak of Marburg virus, a filovirus, in Angola led to a case-fatality rate of 90 percent. However, little information is available regarding the virulence of the Angola strain from this outbreak compare…
View article: Immune-Mediated Systemic Vasculitis as the Proposed Cause of Sudden-Onset Sensorineural Hearing Loss following Lassa Virus Exposure in Cynomolgus Macaques
Immune-Mediated Systemic Vasculitis as the Proposed Cause of Sudden-Onset Sensorineural Hearing Loss following Lassa Virus Exposure in Cynomolgus Macaques Open
Lassa virus is one of the most common causes of viral hemorrhagic fever. A frequent, but as yet unexplained, consequence of infection with Lassa virus is acute, sudden-onset sensorineural hearing loss in one or both ears. Deafness is obser…
View article: Ebola Virus Causes Intestinal Tract Architectural Disruption and Bacterial Invasion in Non-Human Primates
Ebola Virus Causes Intestinal Tract Architectural Disruption and Bacterial Invasion in Non-Human Primates Open
In the 2014–2016 West Africa Ebola Virus (EBOV) outbreak, there was a significant concern raised about the potential for secondary bacterial infection originating from the gastrointestinal tract, which led to the empiric treatment of many …
View article: Clinical Laboratory Values in Human Ebola Virus Disease Support the Relevance of the Intramuscular Ebola-Kikwit Rhesus Model
Clinical Laboratory Values in Human Ebola Virus Disease Support the Relevance of the Intramuscular Ebola-Kikwit Rhesus Model Open
66 (1 May) • 1479of PCV dose schedule on carriage in observational studies, studies must be carried out with a very large sample size or a high prevalence of PCV13 serotype carriage.Meta-analyses of this and other carriage studies should b…
View article: Trial Evaluating Ambulatory Therapy of Travelers’ Diarrhea (TrEAT TD) Study: A Randomized Controlled Trial Comparing 3 Single-Dose Antibiotic Regimens With Loperamide
Trial Evaluating Ambulatory Therapy of Travelers’ Diarrhea (TrEAT TD) Study: A Randomized Controlled Trial Comparing 3 Single-Dose Antibiotic Regimens With Loperamide Open
NCT01618591.
View article: Clinical Laboratory Values as Early Indicators of Ebola Virus Infection in Nonhuman Primates
Clinical Laboratory Values as Early Indicators of Ebola Virus Infection in Nonhuman Primates Open
The Ebola virus (EBOV) outbreak in West Africa during 2013-2016 demonstrated the need to improve Ebola virus disease (EVD) diagnostics and standards of care. This retrospective study compared laboratory values and clinical features of 3 no…
View article: Disease and Injury Epidemiology Among Military Personnel Deployed to West Africa During the 2014–2015 Ebola Outbreak
Disease and Injury Epidemiology Among Military Personnel Deployed to West Africa During the 2014–2015 Ebola Outbreak Open
In November 2014, in response to the Ebola outbreak, the US government sent ~3000 military personnel to West Africa to construct Ebola treatment units, train health care workers and enhance laboratory testing capabilities. We describe the …
View article: Will There Be a Cure for Ebola?
Will There Be a Cure for Ebola? Open
Despite the unprecedented Ebola virus outbreak response in West Africa, no Ebola medical countermeasures have been approved by the US Food and Drug Administration. However, multiple valuable lessons have been learned about the conduct of c…
View article: Deployment of the 1st Area Medical Laboratory in a Split-Based Configuration During the Largest Ebola Outbreak in History
Deployment of the 1st Area Medical Laboratory in a Split-Based Configuration During the Largest Ebola Outbreak in History Open
With proper planning and training, the 1st AML can successfully conduct split-based operations in an outbreak setting, and this capability can be utilized in future operations. The performance of the 1st AML during the current Ebola outbre…