Ronan A Lyons
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View article: Long-term accrual of conditions following myocardial infarction: a study of disease trajectories in the Wales Multimorbidity e-Cohort
Long-term accrual of conditions following myocardial infarction: a study of disease trajectories in the Wales Multimorbidity e-Cohort Open
Background Improved survivorship following myocardial infarction (MI) has resulted in transferred morbidity to other long-term conditions (LTCs). Understanding of disease accrual over time following MI has been limited by a lack of methodo…
View article: Bridging the gap: development of a methodology for retrieving and harmonising body mass index (BMI) from population-level linked electronic health records
Bridging the gap: development of a methodology for retrieving and harmonising body mass index (BMI) from population-level linked electronic health records Open
Objective This study aims to develop a methodology to retrieve, harmonise and evaluate the completeness of national body mass index (BMI) data from linked electronic health record (EHR) sources to build a longitudinal research-ready data a…
View article: Cumulative residential greenness and childhood body mass index
Cumulative residential greenness and childhood body mass index Open
Background: Childhood obesity is a complex and multifaceted public health issue. Several studies have found that children living in greener neighborhoods have a lower body mass index (BMI); however, evidence on longitudinal exposure remain…
View article: ‘Every day was a learning curve’: implementing COVID-19 triage protocols in UK ambulance services—a qualitative study of staff experiences
‘Every day was a learning curve’: implementing COVID-19 triage protocols in UK ambulance services—a qualitative study of staff experiences Open
Background TRIM (What TRIage model is safest and most effective for the Management of 999 callers with suspected COVID-19? A linked outcome study) was an evaluation of models used to triage and manage emergency ambulance service care for p…
View article: How far is too far for adolescents to actively travel to school: Distance thresholds associated with active travel from home to school
How far is too far for adolescents to actively travel to school: Distance thresholds associated with active travel from home to school Open
ObjectivesThe aim of this study is to (a) examine patterns of commuting to school in adolescents adjusting for sex, age, urban/rural, area level deprivation and school type and (b) identify the threshold distance below which adolescents ar…
View article: Assessing access to primary care in rural and urban Wales
Assessing access to primary care in rural and urban Wales Open
ObjectivesThis study aimed to provide evidence related to Primary Care access for individuals in rural Mid-Wales compared to urban areas to support service planning. We addressed the research questions: do individuals register with their n…
View article: Distance children live from attended and nearest age-appropriate school in Wales: potential to inform active and sustainable transport policy and planning
Distance children live from attended and nearest age-appropriate school in Wales: potential to inform active and sustainable transport policy and planning Open
ObjectivesThe distance children live from school is a key factor influencing travel mode choice. Further, some children attend schools that are not their nearest. Comprehensive data on distance to school is limited in Wales, yet vital to i…
View article: Linking administrative and Census 2021 data in Wales, UK: A cross-sectional study examining completeness and representativeness for population linkage analytics.
Linking administrative and Census 2021 data in Wales, UK: A cross-sectional study examining completeness and representativeness for population linkage analytics. Open
Objectives To explore the completeness and representativeness of Census 2021 data linkage within the Secure Anonymised Information Linkage (SAIL) Databank for research on the population of Wales, UK and, understand which subgroups of the p…
View article: An Evaluation of Critical Care Follow-Up Clinic attendance and subsequent Healthcare Utilisation in Wales, UK: A Retrospective, Population-Level Data-Linkage Study
An Evaluation of Critical Care Follow-Up Clinic attendance and subsequent Healthcare Utilisation in Wales, UK: A Retrospective, Population-Level Data-Linkage Study Open
ObjectivesThis study evaluated the impact of critical care follow-up clinics in Wales by comparing demographics between patients who attended or did not attend clinics. Additionally, we assessed the impact of clinic attendance on healthcar…
View article: Vascular dysfunction in diabetes and pharmacotherapeutic opportunities: a focus on endothelial cell health
Vascular dysfunction in diabetes and pharmacotherapeutic opportunities: a focus on endothelial cell health Open
Endothelial dysfunction contributes to the pathogenesis and progression of type 2 diabetes mellitus (T2DM) and cardiovascular disease. Endothelial dysfunction in T2DM has been studied extensively using experimental models and human studies…
View article: Cohort profile: The SAIL long-term conditions e-cohort (SLTC cohort) investigating area-level changes in healthcare resource use in Wales
Cohort profile: The SAIL long-term conditions e-cohort (SLTC cohort) investigating area-level changes in healthcare resource use in Wales Open
IntroductionThe prioritisation of acute cases of coronavirus during the pandemic caused significant disruption to non-urgent healthcare services, creating a backlog of undiagnosed and untreated individuals with long-term conditions. Previo…
View article: Changes in mental health diagnosis and healthcare use in seven European countries before and during the COVID-19 pandemic (2017–21)
Changes in mental health diagnosis and healthcare use in seven European countries before and during the COVID-19 pandemic (2017–21) Open
In the framework of the European Population Health Information Research Infrastructure (PHIRI) project, we analysed the healthcare use for depression and/or anxiety during the coronavirus disease 2019 (COVID-19) pandemic. Aggregated monthl…
View article: Evaluation of the UK's COVID-19 public health policy “Shielding: Results of a linked data matched cohort study
Evaluation of the UK's COVID-19 public health policy “Shielding: Results of a linked data matched cohort study Open
We found no evidence of a protective effect of shielding on SARS-CoV-2 infections or COVID-19 related mortality, an increased rate of hospital acquired infections and increased self-isolation. Shielding during a future pandemic should only…
View article: Admissions, mortality and financial burden associated with acute hospitalisations for sepsis between 2006 and 2018: A national population-level study
Admissions, mortality and financial burden associated with acute hospitalisations for sepsis between 2006 and 2018: A national population-level study Open
Background: We assessed the healthcare and economic burden of sepsis in adult hospitalised patients in Wales, UK. Methods: We analysed hospital admissions to all acute hospitals in Wales via the Secure Anonymised Information Linkage Databa…
View article: Direct and indirect effects of the COVID-19 pandemic on mortality: an individual-level population-scale analysis using linked electronic health records, Wales, United Kingdom, 2016 to 2022
Direct and indirect effects of the COVID-19 pandemic on mortality: an individual-level population-scale analysis using linked electronic health records, Wales, United Kingdom, 2016 to 2022 Open
Background The COVID-19 pandemic resulted in increased mortality directly and indirectly associated with COVID-19. Aim To assess the impact of the COVID-19 pandemic on all-cause and disease-specific mortality and explore potential health i…
View article: Long-term disability following childhood injury: an imperative to monitor and address the continuum of trauma care
Long-term disability following childhood injury: an imperative to monitor and address the continuum of trauma care Open
Background While injuries remain a leading cause of childhood death, increasing proportions of children survive life-threatening injuries. However, robust epidemiological data on their risks of long-term disability are scant, undermining c…
View article: Potential for advances in data linkage and data science to support injury prevention research
Potential for advances in data linkage and data science to support injury prevention research Open
The recent COVID-19 pandemic stimulated unprecedented linkage of datasets worldwide, and while injury is endemic rather than pandemic, there is much to be learned by the injury prevention community from the data science approaches taken to…
View article: Routine outcomes to investigate differences between ethnic minorities and White British people presenting to emergency services for injury: the stakeholder consultation
Routine outcomes to investigate differences between ethnic minorities and White British people presenting to emergency services for injury: the stakeholder consultation Open
Introduction Research has found differences in processes and outcomes of care between people in ethnic minorities and White British populations in some clinical conditions, although findings have been mixed. The Building an understanding o…
View article: Residential mobility amongst children and young people in Wales: A longitudinal study using linked administrative records
Residential mobility amongst children and young people in Wales: A longitudinal study using linked administrative records Open
BackgroundChild poverty remains a major global concern and a child's experience of deprivation is heavily shaped by where they live and the stability of their local neighbourhood. This study examines frequencies and patterns of residential…
View article: Uptake of COVID-19 vaccinations amongst 3,433,483 children and young people across four nations in the UK
Uptake of COVID-19 vaccinations amongst 3,433,483 children and young people across four nations in the UK Open
Background and ObjectivesSARS-CoV-2 infection in children and young people (CYP) can lead to life threatening conditions including COVID-19, transmission to more vulnerable individuals, or even long COVID. Vaccination against COVID-19 redu…
View article: Applying Trial Emulation Methods to Population-Scale Linked Electronic Health Records for Individuals with Multiple Long-Term Conditions Whilst Adjusting for Informative Observations
Applying Trial Emulation Methods to Population-Scale Linked Electronic Health Records for Individuals with Multiple Long-Term Conditions Whilst Adjusting for Informative Observations Open
Background & ObjectivesTrial Emulation methods can be applied to Population-Scale Linked Electronic Health Records (EHR) to generalise the results of Randomised Controlled Trials (RCTs) to a broader patient population. However, the Data Ge…
View article: Modelling The Effects of Multi-Indication Treatment for Multiple Long-Term Conditions Using Population-Scale Linked Electronic Health Records To Inform Healthcare Policy
Modelling The Effects of Multi-Indication Treatment for Multiple Long-Term Conditions Using Population-Scale Linked Electronic Health Records To Inform Healthcare Policy Open
Background and ObjectivesHealthcare decision-making has previously focused on developing recommendations for single conditions. This research aimed to develop a modeling framework to estimate the effects of multi-indication treatment in pe…
View article: Surveillance of violence through health service interactions in Wales: A longitudinal national data linkage study.
Surveillance of violence through health service interactions in Wales: A longitudinal national data linkage study. Open
Objective and ApproachThe study aimed to utilise multiple population-wide linked administrative, health, and survey data sources to identify victims from violence across various sociodemographic groups using healthcare service interactions…
View article: A race against time – an evaluation of lifesaving treatment pathways for patients following cardiac arrest in a non-hospital setting.
A race against time – an evaluation of lifesaving treatment pathways for patients following cardiac arrest in a non-hospital setting. Open
BackgroundCardiac arrest occurs when the heart ceases pumping blood around the body. Most take place outside hospital. A sequence of effective interventions (a “chain of survival”) is essential for patient survival and recovery of organ fu…
View article: Enabling Advanced Multi-Modal Neuroimaging Analysis within a Trusted Research Environment
Enabling Advanced Multi-Modal Neuroimaging Analysis within a Trusted Research Environment Open
IntroductionGlobally, 55 million individuals have dementia, with an increasing annual incident of 10 million. Enabling the development of new multi-modal models can improve the current diagnostic pathways and potentially contribute to earl…
View article: Creating a population-wide Desirable Health Service Utilisation Indicator using linked health and administrative data
Creating a population-wide Desirable Health Service Utilisation Indicator using linked health and administrative data Open
Background and ObjectiveHealthcare research faces challenges in developing metrics that resonate with the general public or policymakers. We created a Desirable Health Service Utilisation Indicator (DHSUI) to address this gap, centred arou…