Anthony S. Zannas
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View article: Diet Quality and Epigenetic Aging in the Women’s Health Initiative
Diet Quality and Epigenetic Aging in the Women’s Health Initiative Open
View article: Stressful life events, social support, and epigenetic aging in the Women's Health Initiative
Stressful life events, social support, and epigenetic aging in the Women's Health Initiative Open
BACKGROUND: Elevated psychosocial stress has been linked with accelerated biological aging, including composite DNA methylation (DNAm) markers that predict aging-related outcomes ("epigenetic age"). However, no study has examined whether s…
View article: Aging-Related Multisystem Dysregulation Over the Adult Life Span and Physical Function in Later Life: The Atherosclerosis Risk in Communities (ARIC) Study
Aging-Related Multisystem Dysregulation Over the Adult Life Span and Physical Function in Later Life: The Atherosclerosis Risk in Communities (ARIC) Study Open
BACKGROUND: Multisystem dysregulation (Dm) shows promise as a metric of aging and predicts mortality. However, Dm needs to be studied with less severe endpoints indicating modifiable aging stages. Physical function, reflecting healthy long…
View article: Cell-Derived Epigenomic Markers of Chronic Stress Distinguish BreastCancer Phenotypes
Cell-Derived Epigenomic Markers of Chronic Stress Distinguish BreastCancer Phenotypes Open
Breast cancer (BC) is a highly prevalent malignancy in women and is often resistant to available therapies, calling for urgent investigation of the molecular mechanisms underlying its pathogenesis and progression. BC is thought to result f…
View article: Epigenetic aging mediates the association between life course socioeconomic status and decrements in kidney function across a decade
Epigenetic aging mediates the association between life course socioeconomic status and decrements in kidney function across a decade Open
Epigenetic aging measures are novel molecular indicators of biological aging that predict age-related chronic disease. We examined whether several established indices of epigenetic aging mediated the association between life course socioec…
View article: Single-cell transcriptomics yield insights into the stress-immune interplay and inform disease risk
Single-cell transcriptomics yield insights into the stress-immune interplay and inform disease risk Open
Environmental stress contributes to several disease conditions – including cardiovascular disease, mental illness, and autoimmune disorders – through immune dysregulation. Stress operates through the hypothalamic-pituitary-adrenal and symp…
View article: Microglia Single‐Cell <scp>RNA</scp>‐Seq Enables Robust and Applicable Markers of Biological Aging
Microglia Single‐Cell <span>RNA</span>‐Seq Enables Robust and Applicable Markers of Biological Aging Open
“Biological aging clocks”—composite molecular markers thought to capture an individual's biological age—have been traditionally developed through bulk‐level analyses of mixed cells and tissues. However, recent evidence highlights the impor…
View article: An open access, machine learning pipeline for high-throughput quantification of cell morphology
An open access, machine learning pipeline for high-throughput quantification of cell morphology Open
View article: Biological Age Mediates the Effects of Perceived Neighborhood Problems on Heart Failure Risk Among Black Persons
Biological Age Mediates the Effects of Perceived Neighborhood Problems on Heart Failure Risk Among Black Persons Open
View article: Cell-type-specific and inflammatory DNA methylation patterns associated with PTSD
Cell-type-specific and inflammatory DNA methylation patterns associated with PTSD Open
This study identifies novel PTSD-associated CpGs in individual immune cell types and supports the role of immune dysregulation and inflammation in PTSD.
View article: The Relationship of Neighborhood Disadvantage, Biological Aging, and Psychosocial Risk and Resilience Factors in Heart Failure Incidence Among Black Persons: A Moderated Mediation Analysis
The Relationship of Neighborhood Disadvantage, Biological Aging, and Psychosocial Risk and Resilience Factors in Heart Failure Incidence Among Black Persons: A Moderated Mediation Analysis Open
OBJECTIVES: Deprived living environments contribute to greater heart failure (HF) risk among non-Hispanic Black persons, who disproportionately occupy disadvantaged neighborhoods. The mechanisms for these effects are not fully explicated, …
View article: Machine learning-based morphological quantification of replicative senescence in human fibroblasts
Machine learning-based morphological quantification of replicative senescence in human fibroblasts Open
View article: Relationships of depression and antidepressant use with epigenetic age acceleration and all-cause mortality among postmenopausal women
Relationships of depression and antidepressant use with epigenetic age acceleration and all-cause mortality among postmenopausal women Open
We investigated relations of depressive symptoms, antidepressant use, and epigenetic age acceleration with all-cause mortality risk among postmenopausal women. Data were analyzed from ≤1,900 participants in the Women's Health Initiative st…
View article: Circulating small RNAs shed new light on dementia risk
Circulating small RNAs shed new light on dementia risk Open
View article: PTSD and epigenetic aging: a longitudinal meta-analysis
PTSD and epigenetic aging: a longitudinal meta-analysis Open
Background Posttraumatic stress disorder (PTSD) has been associated with advanced epigenetic age cross-sectionally, but the association between these variables over time is unclear. This study conducted meta-analyses to test whether new-on…
View article: Post-Traumatic Stress Disorder Moderates the Association between Brainage Acceleration and Grimage Acceleration
Post-Traumatic Stress Disorder Moderates the Association between Brainage Acceleration and Grimage Acceleration Open
View article: Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: a meta-analysis of 23 military and civilian cohorts
Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: a meta-analysis of 23 military and civilian cohorts Open
View article: Influence of occupational stress on breast cancer incidence in the Women’s Health Initiative.
Influence of occupational stress on breast cancer incidence in the Women’s Health Initiative. Open
Our results highlight the potential importance of the occupational domain as a source of stress for women and suggest a possible, but yet tenuous, role in chronic disease etiology. (PsycInfo Database Record (c) 2025 APA, all rights reserve…
View article: Epigenetics as a link between environmental factors and dementia risk
Epigenetics as a link between environmental factors and dementia risk Open
Dementia encompasses a broad spectrum of neuropsychiatric disease states marked by cognitive impairments that interfere with day-to-day functioning. Most dementias are complex phenotypes that result from a genome-environment interplay. Epi…
View article: Leveraging Single-Cell RNA-Seq to Generate Robust Microglia Aging Clocks
Leveraging Single-Cell RNA-Seq to Generate Robust Microglia Aging Clocks Open
‘Biological aging clocks’ - composite molecular markers thought to capture an individual’s biological age - have been traditionally developed through bulk-level analyses of mixed cells and tissues. However, recent evidence highlights the i…
View article: Blood-based DNA methylation and exposure risk scores predict PTSD with high accuracy in military and civilian cohorts
Blood-based DNA methylation and exposure risk scores predict PTSD with high accuracy in military and civilian cohorts Open
Background Incorporating genomic data into risk prediction has become an increasingly popular approach for rapid identification of individuals most at risk for complex disorders such as PTSD. Our goal was to develop and validate Methylatio…
View article: Biological Aging and Mental Illness—A Vicious Cycle?
Biological Aging and Mental Illness—A Vicious Cycle? Open
This Viewpoint discusses biological aging and mental illness.
View article: IL-6 Response to Psychosocial Stress Predicts 12-month Changes in Cardiometabolic Biomarkers in Perimenopausal Women
IL-6 Response to Psychosocial Stress Predicts 12-month Changes in Cardiometabolic Biomarkers in Perimenopausal Women Open
OBJECTIVE: Cardiometabolic diseases are the number one cause of mortality, accounting for over one third of all deaths in the United States. Cardiometabolic risk further increases with psychosocial stress exposure and during menopausal tra…
View article: Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: A meta-analysis of 23 military and civilian cohorts
Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: A meta-analysis of 23 military and civilian cohorts Open
Background The occurrence of post-traumatic stress disorder (PTSD) following a traumatic event is associated with biological differences that can represent the susceptibility to PTSD, the impact of trauma, or the sequelae of PTSD itself. T…
View article: Grandparents' educational attainment is associated with grandchildren's epigenetic-based age acceleration in the National Growth and Health Study
Grandparents' educational attainment is associated with grandchildren's epigenetic-based age acceleration in the National Growth and Health Study Open
View article: Epigenetic aging and PTSD outcomes in the immediate aftermath of trauma
Epigenetic aging and PTSD outcomes in the immediate aftermath of trauma Open
BACKGROUND: Psychological trauma exposure and posttraumatic stress disorder (PTSD) have been associated with advanced epigenetic age. However, whether epigenetic aging measured at the time of trauma predicts the subsequent development of P…
View article: Literature review and methodological considerations for understanding circulating risk biomarkers following trauma exposure
Literature review and methodological considerations for understanding circulating risk biomarkers following trauma exposure Open
View article: Social threat alters the behavioral structure of social motivation and reshapes functional brain connectivity
Social threat alters the behavioral structure of social motivation and reshapes functional brain connectivity Open
Traumatic social experiences redefine socially motivated behaviors to enhance safety and survival. Although many brain regions have been implicated in signaling a social threat, the mechanisms by which global neural networks regulate such …
View article: Relationships of depression and antidepressant use with epigenetic age acceleration and all-cause mortality among postmenopausal women
Relationships of depression and antidepressant use with epigenetic age acceleration and all-cause mortality among postmenopausal women Open
We investigated relations of depressive symptoms, antidepressant use, and epigenetic age acceleration with all-cause mortality risk among postmenopausal women. Data were analyzed from ≤1,900 participants in the Women's Health Initiative st…
View article: Early Life Cardiovascular Risk Factors and Midlife Epigenetic Aging
Early Life Cardiovascular Risk Factors and Midlife Epigenetic Aging Open