A. Petzold
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View article: A biomaterial-based platform of pancreatic cancer reveals kallikrein-related peptidase 6 (KLK6) as a mediator of neutrophil recruitment and immunosuppression
A biomaterial-based platform of pancreatic cancer reveals kallikrein-related peptidase 6 (KLK6) as a mediator of neutrophil recruitment and immunosuppression Open
In pancreatic cancer, response to treatment is impaired by the tumor microenvironment (TME), forming a desmoplastic barrier. However, experimental 3D models that adequately model the pancreatic TME are still missing. Here, we employ a matr…
View article: GGA2-depletion in beta cells by Enteroviruses causes Golgi acidification, premature activation of cathepsins and alters the MHC class I immunopeptidome
GGA2-depletion in beta cells by Enteroviruses causes Golgi acidification, premature activation of cathepsins and alters the MHC class I immunopeptidome Open
Enteroviruses (EVs), such as Coxsackievirus B5 (CVB5), are linked to pancreatic beta cell autoimmunity in type 1 diabetes (T1D). CVB5 infection of beta cells blocks their cap-dependent translation but spares cap-independent translation of …
View article: Functional Dichotomy of Developmental Foxp3<sup>+</sup>Treg Cell Subsets in the Visceral Adipose Tissue of Lean and Obese Mice
Functional Dichotomy of Developmental Foxp3<sup>+</sup>Treg Cell Subsets in the Visceral Adipose Tissue of Lean and Obese Mice Open
SUMMARY Chronic inflammation and loss of Foxp3 + regulatory T (Treg) cells in the visceral adipose tissue (VAT) are hallmarks of the pathogenesis of insulin resistance and obesity. This study explores the roles of VAT Treg cells from thymi…
View article: Extensive monolayer formation depends on a subpopulation of transplanted human iPSC-derived RPE cells
Extensive monolayer formation depends on a subpopulation of transplanted human iPSC-derived RPE cells Open
Loss of retinal pigment epithelium (RPE) cells in the eye leads to photoreceptor death and vision loss. Cell replacement strategies using RPE derived in vitro from pluripotent stem cells (PSCs) has emerged as a promising therapeutic strate…
View article: NCBench: providing an open, reproducible, transparent, adaptable, and continuous benchmark approach for DNA-sequencing-based variant calling
NCBench: providing an open, reproducible, transparent, adaptable, and continuous benchmark approach for DNA-sequencing-based variant calling Open
We present the results of the human genomic small variant calling benchmarking initiative of the German Research Foundation (DFG) funded Next Generation Sequencing Competence Network (NGS-CN) and the German Human Genome-Phenome Archive (GH…
View article: Endocytic adaptor AP-2 maintains Purkinje cell function by balancing cerebellar parallel and climbing fiber synapses
Endocytic adaptor AP-2 maintains Purkinje cell function by balancing cerebellar parallel and climbing fiber synapses Open
The selective loss of cerebellar Purkinje cells is a hallmark of various neurodegenerative movement disorders, yet the precise mechanism driving their degeneration remains enigmatic. Here, we show that the endocytic adaptor protein complex…
View article: The growth factor EPIREGULIN promotes basal progenitor cell proliferation in the developing neocortex
The growth factor EPIREGULIN promotes basal progenitor cell proliferation in the developing neocortex Open
Neocortex expansion during evolution is linked to higher numbers of neurons, which are thought to result from increased proliferative capacity and neurogenic potential of basal progenitor cells during development. Here, we show that EREG ,…
View article: NCBench: providing an open, reproducible, transparent, adaptable, and continuous benchmark approach for DNA-sequencing-based variant calling
NCBench: providing an open, reproducible, transparent, adaptable, and continuous benchmark approach for DNA-sequencing-based variant calling Open
We present the results of the human genomic small variant calling benchmarking initiative of the German Research Foundation (DFG) funded Next Generation Sequencing Competence Network (NGS-CN) and the German Human Genome-Phenome Archive (GH…
View article: Primate-expressed EPIREGULIN promotes basal progenitor proliferation in the developing neocortex
Primate-expressed EPIREGULIN promotes basal progenitor proliferation in the developing neocortex Open
SUMMARY Neocortex expansion during evolution is linked to higher numbers of neurons thought to result from increased proliferative capacity and neurogenic potential of basal progenitor cells (BPs) during development. Here we show that EREG…
View article: The Tgf-β family member Gdf6Y determines the male sex in<i>Nothobranchius furzeri</i>by suppressing oogenesis-inducing genes
The Tgf-β family member Gdf6Y determines the male sex in<i>Nothobranchius furzeri</i>by suppressing oogenesis-inducing genes Open
The short-lived African killifish Nothobranchius furzeri lives in seasonal freshwater ponds and has evolved remarkable traits to survive in this limited environment. One of those traits is a genetic XX/XY sex-determination system, which en…
View article: Sequencing and chromosome-scale assembly of the giant<i>Pleurodeles waltl</i>genome
Sequencing and chromosome-scale assembly of the giant<i>Pleurodeles waltl</i>genome Open
The Iberian ribbed newt ( Pleurodeles waltl ) constitutes a central model for probing the basis of vertebrate regeneration. Here, we present the sequencing and chromosome-scale assembly of the 20.3Gb P. waltl genome, which exhibits the hig…
View article: Cellular senescence promotes progenitor cell expansion during axolotl limb regeneration
Cellular senescence promotes progenitor cell expansion during axolotl limb regeneration Open
SUMMARY Axolotl limb regeneration is accompanied by the transient induction of cellular senescence within the blastema, the structure which nucleates regeneration. The precise role of this blastemal senescent cell (bSC) population, however…
View article: Distinguishing activated T regulatory cell and T conventional cells by single‐cell technologies
Distinguishing activated T regulatory cell and T conventional cells by single‐cell technologies Open
Resting conventional T cells (Tconv) can be distinguished from T regulatory cells (Treg) by the canonical markers FOXP3, CD25 and CD127. However, the expression of these proteins alters after T‐cell activation leading to overlap between Tc…
View article: A single-cell atlas of <i>de novo</i> β-cell regeneration reveals the contribution of hybrid β/δ-cells to diabetes recovery in zebrafish
A single-cell atlas of <i>de novo</i> β-cell regeneration reveals the contribution of hybrid β/δ-cells to diabetes recovery in zebrafish Open
Regeneration-competent species possess the ability to reverse the progression of severe diseases by restoring the function of the damaged tissue. However, the cellular dynamics underlying this capability remain unexplored. Here, we have us…
View article: Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF
Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF Open
Anti-TNF therapies are a core anti-inflammatory approach for chronic diseases such as rheumatoid arthritis and Crohn’s Disease. Previously, we and others found that TNF blocks the emergence and function of alternative-activated or M2 macro…
View article: The RNA binding protein human antigen R is a gatekeeper of liver homeostasis
The RNA binding protein human antigen R is a gatekeeper of liver homeostasis Open
Background and Aims NAFLD is initiated by steatosis and can progress through fibrosis and cirrhosis to HCC. The RNA binding protein human antigen R (HuR) controls RNAs at the posttranscriptional level; hepatocyte HuR has been implicated in…
View article: <i>CEBPA</i> mutations in 4708 patients with acute myeloid leukemia: differential impact of bZIP and TAD mutations on outcome
<i>CEBPA</i> mutations in 4708 patients with acute myeloid leukemia: differential impact of bZIP and TAD mutations on outcome Open
Biallelic mutations of the CEBPA gene (CEBPAbi) define a distinct entity associated with favorable prognosis; however, the role of monoallelic mutations (CEBPAsm) is poorly understood. We retrospectively analyzed 4708 adults with acute mye…
View article: A single-cell atlas of <i>de novo</i> β-cell regeneration reveals the contribution of hybrid β/δ-cells to diabetes recovery in zebrafish
A single-cell atlas of <i>de novo</i> β-cell regeneration reveals the contribution of hybrid β/δ-cells to diabetes recovery in zebrafish Open
Regeneration-competent species possess the ability to reverse the progression of severe diseases by restoring the function of the damaged tissue. However, the cellular dynamics underlying this capability remain unexplored. Here, we use sin…
View article: Tig1 regulates proximo-distal identity during salamander limb regeneration
Tig1 regulates proximo-distal identity during salamander limb regeneration Open
Salamander limb regeneration is an accurate process which gives rise exclusively to the missing structures, irrespective of the amputation level. This suggests that cells in the stump have an awareness of their spatial location, a property…
View article: Graphical Abstract: Angew. Chem. Int. Ed. 51/2020
Graphical Abstract: Angew. Chem. Int. Ed. 51/2020 Open
Protein StructuresIn their Communication on page 22916, R. Linser et al. demonstrate by using NMR spectroscopy combined with MD simulations that the active site of human carbonic anhydrase II shows pronounced open/close conformational exch…