Explanipedia

Spontaneous HFO Sequences Reveal Propagation Pathways for Precise Delineation of Epileptogenic Networks Open

Zhengxiang Cai, Xiyuan Jiang, Anto Bagić, Gregory A. Worrell, R. Mark Richardson , et al. · 2024

Epilepsy, a neurological disorder affecting millions worldwide, poses great challenges in precisely delineating the epileptogenic zone – the brain region generating seizures – for effective treatment. High-frequency oscillations (HFOs) are…

Epilepsy monitoring unit practices and safety among NAEC epilepsy centers: A census survey Open

Anto Bagić, Stephanie M. Ahrens, Kevin Chapman, Shasha Bai, Dave Clarke , et al. · 2023

Deep learning based source imaging provides strong sublobar localization of epileptogenic zone from MEG interictal spikes Open

Rui Sun, Wenbo Zhang, Anto Bagić, Bin He · 2023

Diagnosing Epilepsy with Normal Interictal EEG Using Dynamic Network Models Open

Patrick Myers, Kristin M. Gunnarsdottir, Adam Li, Vlad Razskazovskiy, Dale Wyeth , et al. · 2023

Objective While scalp EEG is important for diagnosing epilepsy, a single routine EEG is limited in its diagnostic value. Only a small percentage of routine EEGs show interictal epileptiform discharges (IEDs) and overall misdiagnosis rates …

ASCEND: A randomized controlled trial of titration strategies for vagus nerve stimulation in drug-resistant epilepsy Open

Anto Bagić, Ryan Verner, Selim R. Benbadis, Pegah Afra, Anto Bagić , et al. · 2023

Vagus Nerve Stimulation (VNS) therapy is widely understood to provide clinically meaningful improvements in seizure control to patients with drug-resistant epilepsy, and has been a staple in the clinical armamentaria available to epileptol…

An Emerging Screening Method for Interrogating Human Brain Function: Tutorial Open

Gustavo Sudre, Anto Bagić, James T. Becker, John P Ford · 2023

Cognitive decline can be observed due to a myriad of causes. Clinicians would benefit from a noninvasive quantitative tool to screen and monitor brain function based on direct measures of neural features. In this study, we used neuroimagin…

Associations between testing and treatment pathways in lesional temporal or extratemporal epilepsy: A census survey of NAEC center directors Open

Christopher W. Beatty, Stephanie M. Ahrens, Kristen H. Arredondo, Anto Bagić, Shasha Bai , et al. · 2023

Objective The evaluation to determine candidacy and treatment for epilepsy surgery in persons with drug‐resistant epilepsy (DRE) is not uniform. Many non‐invasive and invasive tests are available to ascertain an appropriate treatment strat…

Editorial: Magnetoencephalography: Methodological innovation paves the way for scientific discoveries and new clinical applications Open

Rafeed Alkawadri, Rei Enatsu, Matti Hämäläinen, Anto Bagić · 2022

Non peer reviewed

Personalized Deep Learning based Source Imaging Framework Improves the Imaging of Epileptic Sources from MEG Interictal Spikes Open

Rui Sun, Wenbo Zhang, Anto Bagić, Bin He · 2022

Electromagnetic source imaging (ESI) has been widely used to image brain activities for research and clinical applications from MEG and EEG. It is a challenging task due to the ill-posedness of the problem and the complexity of modeling th…

Association Between Characteristics of National Association of Epilepsy Centers and Reported Utilization of Specific Surgical Techniques Open

Kristen H. Arredondo, Stephanie M. Ahrens, Anto Bagić, Shasha Bai, Kevin Chapman , et al. · 2022

Epilepsy surgery procedure volumes are influenced by US epilepsy center region and other characteristics. These variations may affect access to specific surgical treatments for persons with drug resistant epilepsy across the United States.

A new paradigm for investigating real-world social behavior and its neural underpinnings Open

Arish Alreja, Michael Ward, Qianli Ma, Brian E. Russ, Stephan Bickel , et al. · 2022

Disentanglement of Resting State Brain Networks for Localizing Epileptogenic Zone in Focal Epilepsy Open

Shuai Ye, Anto Bagić, Bin He · 2022

Resting state electromagnetic recordings have been analyzed in epilepsy patients aiding presurgical evaluation. However, it has been rarely explored how pathological networks can be separated and thus used for epileptogenic focus localizat…

Contributions of Magnetoencephalography to Understanding Mechanisms of Generalized Epilepsies: Blurring the Boundary Between Focal and Generalized Epilepsies? Open

Thandar Aung, Jeffrey R. Tenney, Anto Bagić · 2022

According to the latest operational 2017 ILAE classification of epileptic seizures, the generalized epileptic seizure is still conceptualized as “originating at some point within and rapidly engaging, bilaterally distributed networks.” In …

An Emerging Screening Method for Interrogating Human Brain Function: Tutorial (Preprint) Open

Gustavo Sudre, Anto Bagić, James T. Becker, John P Ford · 2022

UNSTRUCTURED Cognitive decline can be observed due to a myriad of causes. Clinicians would benefit from a noninvasive quantitative tool to screen and monitor brain function based on direct measures of neural features. In this study, we us…

Interictal SEEG resting-state connectivity localizes seizure onset zone and predicts seizure outcome Open

Haiteng Jiang, Vasileios Kokkinos, Shuai Ye, Alexandra Urban, Anto Bagić , et al. · 2022

Stereotactic-electroencephalography (SEEG) is a common neurosurgical method to localize epileptogenic zone in drug resistant epilepsy patients and inform treatment recommendations. In the current clinical practice, localization of epilepto…

A New Paradigm for Investigating Real-World Social Behavior and its Neural Underpinnings Open

Arish Alreja, Michael Ward, Qianli Ma, Brian E. Russ, Stephan Bickel , et al. · 2021

Eye tracking and other behavioral measurements collected from patient-participants in their hospital rooms afford a unique opportunity to study immersive natural behavior for basic and clinical translational research. We describe an immers…

Imaging the extent and location of spatiotemporally distributed epileptiform sources from MEG measurements Open

Xiyuan Jiang, Shuai Ye, Abbas Sohrabpour, Anto Bagić, Bin He · 2021

Imaging the extent and location of spatiotemporally distributed epileptiform sources from MEG measurements Open

Xiyuan Jiang, Shuai Ye, Abbas Sohrabpour, Anto Bagić, Bin He · 2021

Non-invasive MEG/EEG source imaging provides valuable information about the epileptogenic brain areas which can be used to aid presurgical planning in focal epilepsy patients suffering from drug-resistant seizures. However, the source exte…

Sex Differences in Magnetoencephalography-Identified Functional Connectivity in the Human Connectome Project Connectomics of Brain Aging and Dementia Cohort Open

Ricardo Bruña, Fernando Maestú, David López‐Sanz, Anto Bagić, Ann D. Cohen , et al. · 2021

Introduction: The human brain shows modest traits of sexual dimorphism, with the female brain, on average, 10% smaller than the male brain. These differences do not imply a lowered cognitive performance, but suggest a more op…

Practical Fundamentals of Clinical MEG Interpretation in Epilepsy Open

Christopher Laohathai, John S. Ebersole, John C. Mosher, Anto Bagić, Ai Sumida , et al. · 2021

Magnetoencephalography (MEG) is a neurophysiologic test that offers a functional localization of epileptic sources in patients considered for epilepsy surgery. The understanding of clinical MEG concepts, and the interpretation of these cli…

Intracranial monitoring contributes to seizure freedom for temporal lobectomy patients with nonconcordant preoperative data Open

Elisaveta Sokolov, Nathaniel Sisterson, Helweh Hussein, Cheryl Plummer, Danielle Corson , et al. · 2021

Objective The question of whether a patient with presumed temporal lobe seizures should proceed directly to temporal lobectomy surgery versus undergo intracranial monitoring arises commonly. We evaluate the effect of intracranial monitorin…

Use of Innovative SPECT Techniques in the Presurgical Evaluation of Patients with Nonlesional Extratemporal Drug-Resistant Epilepsy Open

Ahmed Yassin, Khalid El‐Salem, Abdel‐Hameed Al‐Mistarehi, Aiman Momani, Anas M. Zein Alaabdin , et al. · 2021

Up to 30% of patients with epilepsy may not respond to antiepileptic drugs. Patients with drug-resistant epilepsy (DRE) should undergo evaluation for seizure onset zone (SOZ) localization to consider surgical treatment. Cases of drug-resis…

Neonatal Outcomes in the MONEAD Study of Pregnant Women with Epilepsy Open

L.J. Van Marter, Page B. Pennell, Carrie Brown, Adam L. Hartman, Ryan May , et al. · 2021

Ictal Onset Signatures Predict Favorable Outcomes of Laser Thermal Ablation for Mesial Temporal Lobe Epilepsy Open

Naoir Zaher, Alexandra Urban, Arun Antony, Cheryl Plummer, Anto Bagić , et al. · 2020

Background: Laser interstitial thermal therapy (LiTT) has emerged as a minimally invasive option for surgical treatment of refractory epilepsy. However, LiTT of the mesial temporal (MT) structures is still inferior to anterior tempo…

Seizure Detection: Interreader Agreement and Detection Algorithm Assessments Using a Large Dataset Open

Mark L. Scheuer, Scott B. Wilson, Arun Antony, Gena R. Ghearing, Alexandra Urban , et al. · 2020

Purpose: To compare the seizure detection performance of three expert humans and two computer algorithms in a large set of epilepsy monitoring unit EEG recordings. Methods: One hundred twenty prolonged EEGs, 100 containing clinically repor…

Heart versus brain: a case of ictal asystole in temporal lobe epilepsy Open

Ahmed Yassin, Belal Aldabbour, Anto Bagić, Alexandra Urban · 2020

A Rational Approach to Understanding and Evaluating Responsive Neurostimulation Open

Nathaniel Sisterson, Thomas A. Wozny, Vasileios Kokkinos, Anto Bagić, Alexandra Urbán , et al. · 2020

Direct and indirect costs associated with stereotactic radiosurgery or open surgery for medial temporal lobe epilepsy: Results from the <span>ROSE</span> trial Open

John T. Langfitt, Mark Quigg, Guofen Yan, Wei Yu, Mariann M. Ward , et al. · 2019

Objective To determine whether a less‐invasive approach to surgery for medically refractory temporal lobe epilepsy is associated with lower health care costs and costs of lost productivity over time, compared to open surgery. Methods We co…

Corrigendum to “Simultaneous scalp EEG improves seizure lateralization during unilateral intracranial EEG evaluation in temporal lobe epilepsy” [Seizure 64 January (2019) 8–15] Open

Arun Antony, Sergiu Abramovici, Robert T. Krafty, Jullie W. Pan, R. Mark Richardson , et al. · 2019

Radiosurgery versus open surgery for mesial temporal lobe epilepsy: The randomized, controlled <span>ROSE</span> trial Open

Nicholas M. Barbaro, Mark Quigg, Mariann M. Ward, Edward F. Chang, Donna K. Broshek , et al. · 2018

Summary Objective To compare stereotactic radiosurgery ( SRS ) versus anterior temporal lobectomy ( ATL ) for patients with pharmacoresistant unilateral mesial temporal lobe epilepsy ( MTLE ). Methods This randomized, single‐blinded, contr…

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