Antoine Gleizes
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View article: Tet1 safeguards lineage allocation in intestinal stem cells
Tet1 safeguards lineage allocation in intestinal stem cells Open
Intestinal stem cells (ISCs) balance self-renewal and differentiation to maintain the intestinal epithelial barrier, which is replaced weekly throughout adult life. Genetic control of ISC differentiation is well-defined relative to transcr…
View article: <i>Tritrichomonas muris</i> sensitizes the intestinal epithelium to doxorubicin-induced apoptosis
<i>Tritrichomonas muris</i> sensitizes the intestinal epithelium to doxorubicin-induced apoptosis Open
Our study found that the eukaryotic commensal Tritrichomonas muris ( Tmu) significantly increases DXR-induced intestinal apoptosis in mice. Tmu also reduces Lgr5 expression post-DXR injury and elevates inflammation and type 2 cytokine expr…
View article: <i>Lgr5</i> + intestinal stem cells are required for organoid survival after genotoxic injury
<i>Lgr5</i> + intestinal stem cells are required for organoid survival after genotoxic injury Open
Progenitors and mature cells can maintain the intestinal epithelium by dedifferentiation and facultative intestinal stem cell (fISC) function when active ISCs (aISCs) are lost to damage. Here, we modeled fISC activation in mouse intestinal…
View article: <i>Tritrichomonas muris</i>sensitizes the intestinal epithelium to doxorubicin-induced apoptosis
<i>Tritrichomonas muris</i>sensitizes the intestinal epithelium to doxorubicin-induced apoptosis Open
Doxorubicin (DXR) is a widely used chemotherapy drug that can induce severe intestinal mucositis. While the influence of gut bacteria on DXR-induced damage has been documented, the role of eukaryotic commensals remains unexplored. We disco…
View article: <i>Lgr5</i>+ intestinal stem cells are required for organoid survival after genotoxic injury
<i>Lgr5</i>+ intestinal stem cells are required for organoid survival after genotoxic injury Open
Progenitors and mature cells can maintain the intestinal epithelium by dedifferentiation and facultative intestinal stem cell (fISC) function when active ISCs (aISCs) are lost to damage. Here, we sought to model fISC activation in intestin…
View article: Rôle du co-régulateur transcriptionnel RIP140 dans la biologie des cellules souches intestinales normales et cancéreuses et leurs propriétés de chimiorésistance
Rôle du co-régulateur transcriptionnel RIP140 dans la biologie des cellules souches intestinales normales et cancéreuses et leurs propriétés de chimiorésistance Open
The incidence and mortality rate of colorectal cancers (CRC) remain a major health issue worldwide. The understanding of the mechanisms underlying the initiation of oncogenic processes as well as the sequence of event sustaining tumoral de…
View article: RIP140 Represses Intestinal Paneth Cell Differentiation and Interplays with SOX9 Signaling in Colorectal Cancer
RIP140 Represses Intestinal Paneth Cell Differentiation and Interplays with SOX9 Signaling in Colorectal Cancer Open
RIP140 is a major transcriptional coregulator of gut homeostasis and tumorigenesis through the regulation of Wnt/APC signaling. Here, we investigated the effect of RIP140 on Paneth cell differentiation and its interplay with the transcript…
View article: Transcriptional Regulation of the Intestinal Cancer Stem Cell Phenotype
Transcriptional Regulation of the Intestinal Cancer Stem Cell Phenotype Open
Colorectal cancer (CRC) is one of the most frequent cancers worldwide. Current treatments include surgery and chemotherapy, but disease recurrence occurs frequently. The continuous renewal of intestinal epithelium relies on the presence of…