Antoine Jérusalem
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View article: Computational model of cardiac cycle driven brain pulsation: a novel tool for brain disease exploration
Computational model of cardiac cycle driven brain pulsation: a novel tool for brain disease exploration Open
Effective non-invasive detection and tracking of disease progression remains a challenge in medical research. This is particularly critical for brain-related conditions such as Chiari malformations, hydrocephalus or neurodegenerative disor…
View article: Reduced model aided fluid-structure interaction design framework for shunt systems
Reduced model aided fluid-structure interaction design framework for shunt systems Open
Traditionally, clinical devices are designed, tested and improved through lengthy and expensive laboratory experiments and clinical trials [1]. More recently, computational methods have allowed for rapid testing, speeding up the design pro…
View article: Performance of current tools used for on-the-day assessment and diagnosis of mild traumatic brain injury in sport: a systematic review
Performance of current tools used for on-the-day assessment and diagnosis of mild traumatic brain injury in sport: a systematic review Open
Objective The monitoring and diagnosis of sports-related mild traumatic brain injury (SR-mTBI) remains a challenge. This systematic review summarises the current monitoring tools used for on-the-day assessment and diagnosis of SR-mTBI and …
View article: Soft-Finite-Element-Method-Driven Multiphysics Airfoil Optimization
Soft-Finite-Element-Method-Driven Multiphysics Airfoil Optimization Open
The soft finite element method (SoftFEM) was recently developed as an efficient black-box engineering optimization framework combining population-based evolutionary global optimization and a local search technique using a hybrid self-adapt…
View article: Full-field, frequency-domain comparison of simulated and measured human brain deformation
Full-field, frequency-domain comparison of simulated and measured human brain deformation Open
We propose a robust framework for quantitatively comparing model-predicted and experimentally measured strain fields in the human brain during harmonic skull motion. Traumatic brain injuries (TBIs) are typically caused by skull impact or a…
View article: Effects of Fetal Position on the Loading of the Fetal Brain During the Onset of the Second Stage of Labor
Effects of Fetal Position on the Loading of the Fetal Brain During the Onset of the Second Stage of Labor Open
During vaginal delivery, the delivery requires the fetal head to mold to accommodate the geometric constraints of the birth canal. Excessive molding can produce brain injuries and long-term sequelae. Understanding the loading of the fetal …
View article: Extension of the <i>a posteriori</i> finite element method (APFEM) to geometrical alterations and application to stochastic homogenisation
Extension of the <i>a posteriori</i> finite element method (APFEM) to geometrical alterations and application to stochastic homogenisation Open
We recently proposed an efficient method facilitating the parametric study of a finite element mechanical simulation as a postprocessing step, that is, without the need to run multiple simulations: the a posteriori finite element method (A…
View article: Action of the general anaesthetic isoflurane reveals coupling between viscoelasticity and electrophysiological activity in individual neurons
Action of the general anaesthetic isoflurane reveals coupling between viscoelasticity and electrophysiological activity in individual neurons Open
General anaesthetics are widely used for their analgesic, immobilising, and hypnotic effects. The mechanisms underlying these effects remain unclear, but likely arise from alterations to cell microstructure, and potentially mechanics. Here…
View article: The a posteriori finite element method (APFEM), a framework for efficient parametric study and Bayesian inferences
The a posteriori finite element method (APFEM), a framework for efficient parametric study and Bayesian inferences Open
Stochastic methods have recently been the subject of increased attention in Computational Mechanics for their ability to account for the stochasticity of both material parameters and geometrical features in their predictions. Among them, t…
View article: A modular nonlinear stochastic finite element formulation for uncertainty estimation
A modular nonlinear stochastic finite element formulation for uncertainty estimation Open
The Monte Carlo method is widely used for the estimation of uncertainties in mechanical engineering design. However, while flexible, this method remains impractical in terms of computational time and scalability. To bypass these limitation…
View article: Voltage-Driven Alterations to Neuron Viscoelasticity
Voltage-Driven Alterations to Neuron Viscoelasticity Open
The observed effects of membrane voltage on neuron mechanics could be due to piezoelectric or flexoelectric effects and altered ion distributions under the applied voltage. Such effects could change cell mechanics by changing the intermole…
View article: Machine learning based multiscale calibration of mesoscopic constitutive models for composite materials: application to brain white matter
Machine learning based multiscale calibration of mesoscopic constitutive models for composite materials: application to brain white matter Open
A modular pipeline for improving the constitutive modelling of composite materials is proposed.The method is leveraged here for the development of subject-specific spatially-varying brain white matter mechanical properties. For this applic…
View article: A Machine Learning Enhanced Mechanistic Simulation Framework for Functional Deficit Prediction in TBI
A Machine Learning Enhanced Mechanistic Simulation Framework for Functional Deficit Prediction in TBI Open
Resting state functional magnetic resonance imaging (rsfMRI), and the underlying brain networks identified with it, have recently appeared as a promising avenue for the evaluation of functional deficits without the need for active patient …
View article: Single cell electrophysiological alterations under dynamic loading at ultrasonic frequencies
Single cell electrophysiological alterations under dynamic loading at ultrasonic frequencies Open
The use of ultrasound as a non-invasive means to modulate neuronal electrophysiological signals in experimental in vivo and in vitro models has recently been gaining momentum. Paradoxically, the intrinsic mechanisms linking high-frequency …
View article: A Modular Nonlinear Stochastic Finite Element Formulation for Uncertainty Estimation
A Modular Nonlinear Stochastic Finite Element Formulation for Uncertainty Estimation Open
The Monte Carlo method has been widely used for the estimation of uncertainties in mechanical engineering design.However, while extremely flexible, this method remains impractical in terms of computational time and scalability.To bypass th…
View article: Medical imaging based in silico head model for ischaemic stroke simulation
Medical imaging based in silico head model for ischaemic stroke simulation Open
Stroke is one of the most common causes of death and a leading factor of disability in adults worldwide. It occurs when the blood supply to part of the brain is significantly reduced, potentially leading to the formation of brain oedema. O…
View article: Two mechanisms regulate directional cell growth in Arabidopsis lateral roots
Two mechanisms regulate directional cell growth in Arabidopsis lateral roots Open
Morphogenesis in plants depends critically on directional (anisotropic) growth. This occurs principally perpendicular to the net orientation of cellulose microfibrils (CMFs), which is in turn controlled by cortical microtubules (CMTs). In …
View article: Author response: Two mechanisms regulate directional cell growth in Arabidopsis lateral roots
Author response: Two mechanisms regulate directional cell growth in Arabidopsis lateral roots Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract Morphogenesis in p…
View article: Ion current and action potential alterations in peripheral neurons subject to uniaxial strain
Ion current and action potential alterations in peripheral neurons subject to uniaxial strain Open
Peripheral nerves, subject to continuous elongation and compression during everyday movement, contain neuron fibers vital for movement and sensation. At supraphysiological strains resulting from trauma, chronic conditions, aberrant limb po…
View article: Engineering a uniaxial substrate-stretching device for simultaneous electrophysiological measurements and imaging of strained peripheral neurons
Engineering a uniaxial substrate-stretching device for simultaneous electrophysiological measurements and imaging of strained peripheral neurons Open
Peripheral nerves are continuously subjected to mechanical strain during everyday movements, but excessive stretch can lead to damage and neuronal cell functionality can also be impaired. To better understand cellular processes triggered b…
View article: Computational model of the mechanoelectrophysiological coupling in axons with application to neuromodulation
Computational model of the mechanoelectrophysiological coupling in axons with application to neuromodulation Open
For more than half a century, the action potential (AP) has been considered a purely electrical phenomenon. However, experimental observations of membrane deformations occurring during APs have revealed that this process also involves mech…