Antoine Tabarin
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View article: Impact of steroid differentiation on tumor microenvironment revealed by single-nucleus atlas of adrenal tumors
Impact of steroid differentiation on tumor microenvironment revealed by single-nucleus atlas of adrenal tumors Open
View article: OR18-04 Urine Steroid Metabolomics and Timed Urine Steroid Profiling: A Novel Test for the Diagnosis and Differential Diagnosis of Cushing’s Syndrome
OR18-04 Urine Steroid Metabolomics and Timed Urine Steroid Profiling: A Novel Test for the Diagnosis and Differential Diagnosis of Cushing’s Syndrome Open
Disclosure: A. Prete: HRA Pharmaceuticals, Lundbeck, Diurnal. L. Adbi: None. J.T. Bain: None. F. Shaheen: None. O. Suntornlohanakul: None. E. Deflorenne: None. A. Blanchard: None. M. Nestola: None. C. Pamporaki: None. I. Tizianel: None. E.…
View article: Update on Medical Treatment of Cushing’s Syndrome
Update on Medical Treatment of Cushing’s Syndrome Open
First-line treatment of endogenous Cushing's syndrome (CS) is surgical removal of the tumor responsible for cortisol excess. However, medical therapy has an established role in treatment when patients are not surgical candidates or decline…
View article: The mutational landscape of ARMC5 in Primary Bilateral Macronodular Adrenal Hyperplasia: an update
The mutational landscape of ARMC5 in Primary Bilateral Macronodular Adrenal Hyperplasia: an update Open
View article: 7790 A Non-interventional, Multinational, Phase IV Study to Evaluate the Long-Term Safety and Efficacy of Osilodrostat in Patients with Endogenous Cushing's Syndrome (LINC 6): 1-Year Real-World Interim Analysis
7790 A Non-interventional, Multinational, Phase IV Study to Evaluate the Long-Term Safety and Efficacy of Osilodrostat in Patients with Endogenous Cushing's Syndrome (LINC 6): 1-Year Real-World Interim Analysis Open
Disclosure: I. Bancos: Advisory Board Member; Self; Adrenas, Diurnal, Neurocrine, Spruce, HRA Pharmaceuticals, Sparrow, Recordati Rare Diseases, Xeris, Novo Nordisk, AstraZeneca, Corcept. Consulting Fee; Self; Adrenas, Diurnal, Neurocrine,…
View article: Improvement in clinical features of hypercortisolism during osilodrostat treatment: findings from the Phase III LINC 3 trial in Cushing's disease
Improvement in clinical features of hypercortisolism during osilodrostat treatment: findings from the Phase III LINC 3 trial in Cushing's disease Open
View article: Impact of exenatide on weight loss and eating behavior in adults with craniopharyngioma-related obesity: the CRANIOEXE randomized placebo-controlled trial
Impact of exenatide on weight loss and eating behavior in adults with craniopharyngioma-related obesity: the CRANIOEXE randomized placebo-controlled trial Open
Importance A major issue in the management of craniopharyngioma-related obesity (CRO) is the ineffectiveness of the current therapeutic approaches. Objective To study the efficacy of glucagon-like peptide-1 analogs compared with placebo in…
View article: Case report: Complete restoration of the HPA axis function in Cushing’s disease with drug treatment
Case report: Complete restoration of the HPA axis function in Cushing’s disease with drug treatment Open
This report describes a rare case of a 20-year-old man with an ACTH- and prolactin-secreting invasive pituitary macroadenoma causing hyperprolactinemia and Cushing’s disease. He was later found to have an AIP mutation. Treatment with caber…
View article: Comorbidities in mild autonomous cortisol secretion and the effect of treatment: systematic review and meta-analysis
Comorbidities in mild autonomous cortisol secretion and the effect of treatment: systematic review and meta-analysis Open
Objective To assess (1) comorbidities associated with and (2) treatment strategies for patients with adrenal incidentalomas and mild autonomous cortisol secretion (MACS; > 1.8 µg/dL (>50 nmol/L) cortisol level cut-off following the 1…
View article: THU504 Is Carney Complex A Predisposing Syndrome For Breast Cancer? Prospective Study Of 50 Women
THU504 Is Carney Complex A Predisposing Syndrome For Breast Cancer? Prospective Study Of 50 Women Open
Disclosure: P. Vaduva: None. F. Violon: None. A. Jouinot: None. L. Bouys: None. S. Espiard: None. F. Bonnet-Serrano: None. N. Marie Odile: None. C. Cardot-bauters: None. G. Raverot: None. S. Hieronimus: None. H. Lefebvre: None. M.L. Nunes:…
View article: Recommandations du réseau national ENDOCAN-COMETE pour la prise en charge des phéochromocytomes et paragangliomes métastatiques
Recommandations du réseau national ENDOCAN-COMETE pour la prise en charge des phéochromocytomes et paragangliomes métastatiques Open
Pheochromocytomas and paragangliomas are rare neuroendocrine tumors, developed respectively in the adrenal medulla and in extra-adrenal locations. Their malignancy is defined by the presence of distant metastases. Forty percent of them are…
View article: European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European Network for the Study of Adrenal Tumors
European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European Network for the Study of Adrenal Tumors Open
Adrenal incidentalomas are adrenal masses detected on imaging performed for reasons other than suspected adrenal disease. In most cases, adrenal incidentalomas are nonfunctioning adrenocortical adenomas but may also require therapeutic int…
View article: Evidence of Persistent Mild Hypercortisolism in Patients Medically Treated for Cushing Disease: the Haircush Study
Evidence of Persistent Mild Hypercortisolism in Patients Medically Treated for Cushing Disease: the Haircush Study Open
Context Cortisol-lowering drugs may not restore a normal cortisol secretion in Cushing disease (CD). Objective This work aimed to assess the long-term cortisol exposure in medically treated CD patients using hair-cortisol (HF) and hair-cor…
View article: Recommandations conjointes du réseau National ENDOCAN-COMETE, de l’Association francophone de chirurgie endocrinienne et de la Société française d’urologie pour la prise en charge du carcinome corticosurrénalien
Recommandations conjointes du réseau National ENDOCAN-COMETE, de l’Association francophone de chirurgie endocrinienne et de la Société française d’urologie pour la prise en charge du carcinome corticosurrénalien Open
View article: Cushing's syndrome in the elderly: data from the European Registry on Cushing's syndrome
Cushing's syndrome in the elderly: data from the European Registry on Cushing's syndrome Open
Objective To evaluate whether age-related differences exist in clinical characteristics, diagnostic approach, and management strategies in patients with Cushing's syndrome (CS) included in the European Registry on Cushing's Syndrome (ERCUS…
View article: Efficacy and Safety of Osilodrostat in Paraneoplastic Cushing Syndrome: A Real-World Multicenter Study in France
Efficacy and Safety of Osilodrostat in Paraneoplastic Cushing Syndrome: A Real-World Multicenter Study in France Open
Context Prospective studies have demonstrated the efficacy of osilodrostat in Cushing disease. No study has evaluated osilodrostat in a series of patients with paraneoplastic Cushing syndrome/ectopic adrenocorticotropin syndrome (PNCS/EAS)…
View article: PMON163 Effect of Osilodrostat on Androgens and Adrenal Hormones in Patients With Cushing's Disease: Long-Term Findings From the Phase III, Prospective LINC 3 Study
PMON163 Effect of Osilodrostat on Androgens and Adrenal Hormones in Patients With Cushing's Disease: Long-Term Findings From the Phase III, Prospective LINC 3 Study Open
Introduction Osilodrostat decreases cortisol production by inhibiting 11β-hydroxylase, which increases adrenal hormones proximal to the blockade. Here, we describe these effects of osilodrostat and associated adverse events (AEs). The effi…
View article: OR12-3 Identification of Predictive Criteria for the Primary Bilateral Macronodular Adrenal Hyperplasia Gene ARMC5: A European Series of 352 Unselected Patients.
OR12-3 Identification of Predictive Criteria for the Primary Bilateral Macronodular Adrenal Hyperplasia Gene ARMC5: A European Series of 352 Unselected Patients. Open
Objective Primary Bilateral Macronodular Adrenal Hyperplasia (PBMAH) is a heterogeneous disease characterized by adrenal macronodules and variable levels of cortisol excess, with not clearly established clinical diagnostic criteria. PBMAH …
View article: Management after initial surgery of nonfunctioning pituitary adenoma: surveillance, radiotherapy or surgery?
Management after initial surgery of nonfunctioning pituitary adenoma: surveillance, radiotherapy or surgery? Open
Introduction The first line of treatment for nonfunctioning pituitary adenoma (NFPA) is surgery. Adjuvant radiotherapy or surveillance and new treatment (second surgical operation or salvage radiotherapy) in case of recurrence are options …
View article: Predictive Factors of Somatostatin Receptor Ligand Response in Acromegaly—A Prospective Study
Predictive Factors of Somatostatin Receptor Ligand Response in Acromegaly—A Prospective Study Open
Context Somatostatin receptor ligands (SRLs) are the cornerstone medical treatments for acromegaly; however, many patients remain unresponsive to SRLs. Well-established predictive markers of response are needed. Objective We aimed to explo…
View article: Systematic detection of mosaicism by using digital NGS reveals three new MEN1 mosaicisms
Systematic detection of mosaicism by using digital NGS reveals three new MEN1 mosaicisms Open
Purpose Mosaicism is a feature of several inherited tumor syndromes. Only a few cases of mosaicism have been described in multiple endocrine neoplasia type 1 (MEN1). Next-generation sequencing (NGS) offers new possibilities for detecting m…
View article: Impaired quality of life, but not cognition, is linked to a history of chronic hypercortisolism in patients with Cushing’s disease in remission
Impaired quality of life, but not cognition, is linked to a history of chronic hypercortisolism in patients with Cushing’s disease in remission Open
Context Impaired cognition and altered quality of life (QoL) may persist despite long-term remission of Cushing’s disease (CD). Persistent comorbidities and treatment modalities may account for cognitive impairments. Therefore, the role of…
View article: Unmet needs in Cushing’s syndrome: the patients’ perspective
Unmet needs in Cushing’s syndrome: the patients’ perspective Open
Background Cushing’s syndrome (CS) is a rare condition of chronically elevated cortisol levels resulting in diverse comorbidities, many of which endure beyond successful treatment affecting the quality of life. Few data are available conce…
View article: Identification of predictive criteria for pathogenic variants of primary bilateral macronodular adrenal hyperplasia (PBMAH) gene <i>ARMC5</i> in 352 unselected patients
Identification of predictive criteria for pathogenic variants of primary bilateral macronodular adrenal hyperplasia (PBMAH) gene <i>ARMC5</i> in 352 unselected patients Open
Objective Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a heterogeneous disease characterized by adrenal macronodules and variable levels of cortisol excess, with not clearly established clinical diagnostic criteria. It can…
View article: Osilodrostat for the Treatment of Cushing’s Disease: Growing Evidence in the Treatment of Rare Endocrine Diseases
Osilodrostat for the Treatment of Cushing’s Disease: Growing Evidence in the Treatment of Rare Endocrine Diseases Open
Journal Article Osilodrostat for the Treatment of Cushing’s Disease: Growing Evidence in the Treatment of Rare Endocrine Diseases Get access Antoine Tabarin Antoine Tabarin Department of Endocrinology, Diabetes and Nutrition, CHU of Bordea…
View article: Consensus statement by the French Society of Endocrinology (SFE) and French Society of Pediatric Endocrinology & Diabetology (SFEDP) on diagnosis of Cushing's syndrome
Consensus statement by the French Society of Endocrinology (SFE) and French Society of Pediatric Endocrinology & Diabetology (SFEDP) on diagnosis of Cushing's syndrome Open
View article: Life expectancy and likelihood of surgery in multiple endocrine neoplasia type 1: AFCE and GTE cohort study
Life expectancy and likelihood of surgery in multiple endocrine neoplasia type 1: AFCE and GTE cohort study Open
Background The overall natural history, risk of death and surgical burden of patients with multiple endocrine neoplasia type 1 (MEN1) is not well known. Methods Patients with MEN1 from a nationwide cohort were included. The survival of pat…
View article: Dormoy al - suppl Table 1.pdf
Dormoy al - suppl Table 1.pdf Open
Prospective studies have demonstrated the efficacy of osilodrostat in Cushing's disease. No study has evaluated osilodrostat in a series of patients with paraneoplastic Cushing’s syndrome/ectopic ACTH syndrome (PNCS/EAS). Objective: Evalua…
View article: Dormoy al - suppl Table 1.pdf
Dormoy al - suppl Table 1.pdf Open
Prospective studies have demonstrated the efficacy of osilodrostat in Cushing's disease. No study has evaluated osilodrostat in a series of patients with paraneoplastic Cushing’s syndrome/ectopic ACTH syndrome (PNCS/EAS). Objective: Evalua…
View article: Pituitary Society Delphi Survey: An international perspective on endocrine management of patients undergoing transsphenoidal surgery for pituitary adenomas
Pituitary Society Delphi Survey: An international perspective on endocrine management of patients undergoing transsphenoidal surgery for pituitary adenomas Open