Antoinette van Hoven-Beijen
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View article: Immunotherapy for rapid bone marrow conditioning and leukemia depletion that allows efficient hematopoietic stem cell transplantation
Immunotherapy for rapid bone marrow conditioning and leukemia depletion that allows efficient hematopoietic stem cell transplantation Open
Hematopoietic stem cell transplantation (HSCT) is a life-saving procedure to treat hematopoietic disorders. Current bone marrow conditioning protocols create space for healthy donor stem cells by employing irradiation and/or chemotherapy, …
View article: The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis
The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis Open
MIR139 is a tumor suppressor and is commonly silenced in acute myeloid leukemia (AML). However, the tumor-suppressing activities of miR-139 and molecular mechanisms of MIR139 -silencing remain largely unknown. Here, we studied the poorly p…
View article: The miR-200c/141-ZEB2-TGFβ axis is aberrant in human T-cell prolymphocytic leukemia
The miR-200c/141-ZEB2-TGFβ axis is aberrant in human T-cell prolymphocytic leukemia Open
T-cell prolymphocytic leukemia (T-PLL) is mostly characterized by aberrant expansion of small- to medium-sized prolymphocytes with a mature post-thymic phenotype, high aggressiveness of the disease and poor prognosis. However, T-PLL is mor…