Anton Doubell
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View article: MobitzType 1 atrioventricular block: A retrospective assessment of the natural history and need for pacing in 45–64-year-olds
MobitzType 1 atrioventricular block: A retrospective assessment of the natural history and need for pacing in 45–64-year-olds Open
View article: Blood RNA biomarkers and C-reactive protein for triage of adult patients with tuberculosis lymphadenitis and pericarditis in South Africa: a single-centre, prospective, observational, diagnostic accuracy study
Blood RNA biomarkers and C-reactive protein for triage of adult patients with tuberculosis lymphadenitis and pericarditis in South Africa: a single-centre, prospective, observational, diagnostic accuracy study Open
South African Medical Research Council, European and Developing Countries Clinical Trials Partnership 2, National Institutes of Health/National Institute of Allergy and Infectious Diseases, Wellcome Trust, National Institute for Health and…
View article: <i>Bartonella</i> endocarditis: a complex diagnosis of blood culture-negative endocarditis in an endemic region of Africa
<i>Bartonella</i> endocarditis: a complex diagnosis of blood culture-negative endocarditis in an endemic region of Africa Open
Introduction Bartonella species are an important emerging cause of blood culture-negative endocarditis (BCNE). The diagnosis requires serology by indirect immunofluorescence assay (IFA) and PCR testing on blood and/or tissue. Access to the…
View article: Contemporary study of acute myocarditis in South Africa: CAMISA
Contemporary study of acute myocarditis in South Africa: CAMISA Open
Aims This study aims to determine the clinical presentations, aetiologies and outcomes of patients presenting with acute myocarditis (AM) in South Africa. Methods This is a prospective cohort study. Consecutive patients presenting to Tyger…
View article: Parvovirus B19 Myocarditis: The Utility of Viral Load Assessment in Determining the Significance of a Virus Positive Biopsy in South Africa
Parvovirus B19 Myocarditis: The Utility of Viral Load Assessment in Determining the Significance of a Virus Positive Biopsy in South Africa Open
Background/Objectives Parvovirus B19 (PVB19) is the most frequently detected virus in endomyocardial biopsy (EMB) specimens of patients with acute myocarditis in both the developed world and South Africa. Its pathogenic role, however, rema…
View article: ABS0220 INTERLEUKIN-6 IN LUPUS MYOCARDITIS – FRIEND OR FOE
ABS0220 INTERLEUKIN-6 IN LUPUS MYOCARDITIS – FRIEND OR FOE Open
View article: Utility of Serum Biomarkers of Myocardial Fibrosis in High-Gradient Severe Aortic Stenosis: An Explorative Cardiovascular Magnetic Resonance Imaging-Based Study
Utility of Serum Biomarkers of Myocardial Fibrosis in High-Gradient Severe Aortic Stenosis: An Explorative Cardiovascular Magnetic Resonance Imaging-Based Study Open
Background: Myocardial fibrosis in aortic stenosis (AS) is associated with a significant risk of poor clinical outcomes. Myocardial fibrosis can be evaluated using cardiovascular magnetic resonance (CMR) imaging and may be useful for risk-…
View article: Evaluation of the Haemodynamic Behaviour of Stenosed Aortic Heart Valves Using Fuid Structure Interaction Modelling
Evaluation of the Haemodynamic Behaviour of Stenosed Aortic Heart Valves Using Fuid Structure Interaction Modelling Open
Aortic stenosis is a valvular heart disease characterised by the narrowing of the valve opening area. Calcific and rheumatic aortic stenosis (AS) have distinctly different valve morphologies. The haemodynamic environment of generic calcifi…
View article: Bad company? The pericardium microbiome in people investigated for tuberculous pericarditis in an HIV-prevalent setting
Bad company? The pericardium microbiome in people investigated for tuberculous pericarditis in an HIV-prevalent setting Open
View article: Eradicating rheumatic heart disease in Africa: have we made progress since the Drakensberg declaration?
Eradicating rheumatic heart disease in Africa: have we made progress since the Drakensberg declaration? Open
View article: Quantification of Replacement Fibrosis in Aortic Stenosis: A Narrative Review on the Utility of Cardiovascular Magnetic Resonance Imaging
Quantification of Replacement Fibrosis in Aortic Stenosis: A Narrative Review on the Utility of Cardiovascular Magnetic Resonance Imaging Open
Aortic stenosis (AS) is associated with the development of replacement myocardial fibrosis/scar. Given the dose-dependent relationship between scar and clinical outcomes after aortic valve replacement (AVR) surgery, scar quantity may serve…
View article: Editorial: Global Excellence in Cardiovascular Medicine in Africa: challenges and opportunities
Editorial: Global Excellence in Cardiovascular Medicine in Africa: challenges and opportunities Open
View article: Characterizing myocardial edema and fibrosis in hypertensive crisis with cardiovascular magnetic resonance imaging
Characterizing myocardial edema and fibrosis in hypertensive crisis with cardiovascular magnetic resonance imaging Open
A hypertensive crisis is associated with an increased risk of cardiovascular events. Although altered cardiac structure, function, and myocardial architecture on cardiovascular magnetic resonance (CMR) have been associated with increased a…
View article: Blood RNA signatures outperform CRP triage of tuberculosis lymphadenitis and pericarditis
Blood RNA signatures outperform CRP triage of tuberculosis lymphadenitis and pericarditis Open
Background Limited data are available on the diagnostic accuracy of blood RNA biomarker signatures for extrapulmonary TB (EPTB). We addressed this question among people investigated for TB lymphadenitis and TB pericarditis, in Cape Town, S…
View article: Bad company? The pericardium microbiome in people investigated for tuberculosis pericarditis in an HIV-prevalent setting
Bad company? The pericardium microbiome in people investigated for tuberculosis pericarditis in an HIV-prevalent setting Open
Background The microbiome likely plays a role in tuberculosis (TB) pathogenesis. We evaluated the site-of-disease microbiome and predicted metagenome in people with presumptive tuberculous pericarditis, a major cause of mortality, and expl…
View article: Novel role of cardiovascular MRI to contextualise tuberculous pericardial inflammation and oedema as predictors of constrictive pericarditis
Novel role of cardiovascular MRI to contextualise tuberculous pericardial inflammation and oedema as predictors of constrictive pericarditis Open
Tuberculosis (TB) and human immunodeficiency virus/acquired immunodeficiency syndrome have reached epidemic proportions, particularly affecting vulnerable populations in low- and middle-income countries of sub-Saharan Africa. TB pericardit…
View article: P36 Lupus myocarditis: the role of cardiac MRI and endomyocardial biopsy as diagnostic parameters
P36 Lupus myocarditis: the role of cardiac MRI and endomyocardial biopsy as diagnostic parameters Open
Background Lupus myocarditis (LM) is a rare but potentially fatal complication occurring in 5–10% of patients with systemic lupus erythematosus (SLE). Endomyocardial biopsy (EMB) is regarded as the diagnostic gold-standard for myocarditis …
View article: Echocardiographic features of infective endocarditis in South Africa: A prospective cohort study
Echocardiographic features of infective endocarditis in South Africa: A prospective cohort study Open
Background: Historically, infective endocarditis(IE) in South Africa was associated with the viridans group of streptococci affecting patients with underlying rheumatic heart disease(RHD). A changing IE bacteriological profile raises the q…
View article: Short-term outcomes of secondary tricuspid regurgitation after left-sided heart valve surgery
Short-term outcomes of secondary tricuspid regurgitation after left-sided heart valve surgery Open
Background: Secondary tricuspid regurgitation (TR) is a common finding in patients undergoing surgery for leftsided heart valve disease. The indications for concomitant tricuspid valve (TV) repair have been progressively expanded based on …
View article: A case-based narrative review on the structural myocardial changes associated with systolic dysfunction in severe aortic stenosis
A case-based narrative review on the structural myocardial changes associated with systolic dysfunction in severe aortic stenosis Open
Severe aortic stenosis (AS) is not a disease of the valve only, but one involving the myocardium. Left ventricular systolic dysfunction in severe AS is associated with worse outcomes, despite aortic valve replacement (AVR). This case-based…
View article: Afterload Mismatch in Severe Aortic Stenosis: A Case of Inadequate Left Ventricular Hypertrophy or Not?
Afterload Mismatch in Severe Aortic Stenosis: A Case of Inadequate Left Ventricular Hypertrophy or Not? Open
View article: Characteristics and outcomes of infective endocarditis in South Africa: A retrospective cohort study
Characteristics and outcomes of infective endocarditis in South Africa: A retrospective cohort study Open
Background: Infective endocarditis (IE) remains a disease with significant morbidity and mortality for a predominantly young group of patients in South Africa. There is a paucity of data assessing contemporary outcomes of IE in South Afric…
View article: Subclinical cardiovascular remodelling in HIV-infection: a multimodal descriptive study of two serodiscordant, monozygotic twins
Subclinical cardiovascular remodelling in HIV-infection: a multimodal descriptive study of two serodiscordant, monozygotic twins Open
Cardiovascular abnormalities have been demonstrated in people living with HIV at the time of HIV diagnosis, but pathology may be challenging to diagnose in the individual. To describe subtle cardiovascular remodelling and dysfunction in tw…
View article: Antiretroviral therapy and HIV‐associated cardiovascular disease: a prospective cardiac biomarker and CMR tissue characterization study
Antiretroviral therapy and HIV‐associated cardiovascular disease: a prospective cardiac biomarker and CMR tissue characterization study Open
Aims Biochemical markers are fundamental in cardiac evaluation, and various novel assays have recently been discovered. We prospectively evaluated the hearts of newly diagnosed people living with human immunodeficiency virus (PLWH) using c…
View article: Development and testing of a transcatheter heart valve with reduced calcification potential
Development and testing of a transcatheter heart valve with reduced calcification potential Open
Introduction Patients from developing countries who require heart valve surgery are younger and have less access to open heart surgery than those from developed countries. Transcatheter heart valves (THVs) may be an alternative but are cur…
View article: Clinical Profile of Patients with Hypertensive Emergency Referred to aTertiary Hospital in the Western Cape Province of South Africa
Clinical Profile of Patients with Hypertensive Emergency Referred to aTertiary Hospital in the Western Cape Province of South Africa Open
Background:: Despite advances in managing hypertension, hypertensive emergencies remain a common indication for emergency room visits. Our study aimed to determine the clinical profile of patients referred with hypertensive emergencies. Me…
View article: Exploring the mechanisms responsible for afterload mismatch in severe aortic stenosis
Exploring the mechanisms responsible for afterload mismatch in severe aortic stenosis Open
Introduction Afterload mismatch (AM) is defined as a reduced ejection fraction (EF) in the setting of severe aortic stenosis (AS) (aortic valve area (AVA) of < 1cm2), but with transaortic pressure gradients in the severe range. The path…
View article: Impact of hypertension on mean transvalvular gradients in aortic stenosis Lessons learned from in silico modelling
Impact of hypertension on mean transvalvular gradients in aortic stenosis Lessons learned from in silico modelling Open
Introduction The influence of hypertension on the diagnostic assessment of aortic stenosis (AS) severity is unclear, yet clinically relevant. To clarify the effect of hypertension on transvalvular gradients, requires a better understanding…
View article: A retrospective audit of young adults who received permanent pacemakers at a teaching hospital in the Western Cape, South Africa
A retrospective audit of young adults who received permanent pacemakers at a teaching hospital in the Western Cape, South Africa Open
Introduction While most pacemaker implantations occur in older individuals, younger patients also receive pacemakers. In these, degenerative conduction system disease is less likely to be the cause of atrioventricular block (AVB), with oth…
View article: Myocardial Tissue Characterization in Patients with Hypertensive Crisis, Positive Troponin, and Unobstructed Coronary Arteries: A Cardiovascular Magnetic Resonance-Based Study
Myocardial Tissue Characterization in Patients with Hypertensive Crisis, Positive Troponin, and Unobstructed Coronary Arteries: A Cardiovascular Magnetic Resonance-Based Study Open
Hypertensive crisis can present with cardiac troponin elevation and unobstructed coronary arteries. We used cardiac magnetic resonance (CMR) imaging to characterize the myocardial tissue in patients with hypertensive crisis, elevated cardi…