Anton Friedmann
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Hyaluronic acid promotes biomineralization of osteoblast-like cells – observations on two different barrier membranes Open
Background Guided bone regeneration (GBR) relies on biocompatible membranes to support osteogenesis. 1,4-butanediol diglycidyl ether (BDDE)-crosslinked hyaluronic acid (xHyA) has shown promise in enhancing bone regeneration, yet its mechan…
Extracellular Vesicles Derived From Lipopolysaccharide‐Challenged Gingival Fibroblast Reveal Distinct miRNA Expression Patterns Associated With Reduced Cancer Survival Open
Objectives Periodontitis is a prevalent inflammatory disease with established systemic implications. Extracellular vesicles (EVs) have emerged as key mediators of intercellular communication, potentially linking periodontitis to systemic d…
Usage of a “Unique” Digital Surgical Guide for Simultaneous Crown Lengthening, Implant Placement, and Soft Tissue Thickening in the Esthetic Zone Open
Managing complex esthetic cases involving crown lengthening and anterior implant placement in compromised ridges often requires a staged, multidisciplinary approach. Such treatment modality is often lengthy and demanding for both the patie…
Reconstructive surgical therapy of peri-implant defects with ribose cross-linked collagen matrix and crosslinked hyaluronic acid – a prospective case series Open
Objective To investigate the efficacy of ribose-crosslinked collagen (RCLC) matrices functionalized by crosslinked hyaluronic acid (xHya) for reconstructive treatment of class I and III (b-c) peri-implantitis lesions in a transmucosal heal…
Non-surgical treatment of residual periodontal pockets using sodium hypochlorite/amino acid gel and cross-linked hyaluronic acid—a 9-month pilot randomized controlled clinical trial Open
Objectives This pilot randomized controlled clinical trial compares the clinical outcome obtained in persistent periodontal pockets during 9-month follow-up of supportive periodontal step 4 treatment performed by either combining subgingiv…
Reconstructive surgical therapy of peri-implant defects with ribose cross-linked collagen matrix and crosslinked hyaluronic acid – a prospective case series Open
Aims This prospective case series investigated the efficacy of ribose-crosslinked collagen (RCLC) matrices functionalized by crosslinked hyaluronic acid (xHya) for reconstructive treatment of class I and III (b-c) peri-implantitis lesions …
Non-surgical treatment of residual periodontal pockets using sodium hypochlorite/amino acid gel and cross-linked hyaluronic acid - a 9-month pilot randomized controlled clinical trial Open
Objectives: This pilot randomized controlled clinical trial compares the clinical outcome obtained in persistent periodontal pockets during 9-month follow-up of supportive periodontal step 4 treatment performed by either combining subgingi…
Microbiological Effects of Sodium Hypochlorite/-Amino Acids and Cross-linked Hyaluronic Acid Adjunctive to Non-surgical Periodontal Treatment. Open
The present microbiological results, which are related to short-term outcomes up to 6 months post-treatment, support the adjunctive subgingival application of sodium hypochlorite/amino acids and xHyA to subgingival debridement in the treat…
Reconstructive Approach in Residual Periodontal Pockets with Biofunctionalized Heterografts—A Retrospective Comparison of 12-Month Data from Three Centers Open
The regenerative capacity of well-preserved blood clots may be enhanced by biologics like enamel matrix derivative (EMD). This retrospective analysis compares outcomes reported by three centers using different heterografts. Center 1 (C1) t…
Reconstructive Approach in Residual Periodontal Pockets with Biofunctionalized Heterografts – a Retrospective Comparison of 12-Months Data from Three Centers Open
Regenerative capacity of well-preserved blood clot may be enhanced by biologics like enamel matrix derivative (EMD). This retrospective analysis compares outcomes reported by three centers using different heterografts. Center 1 (C1) treate…
Prenyltransferase gene expression reveals an essential role of prenylation for the inflammatory response in human gingival fibroblasts Open
Background Prenyltrasferases (PTases) are a class of enzymes known to be responsible for promoting posttranslational modification at the carboxyl terminus of proteins containing a so‐called CaaX‐motif. The process is responsible for proper…
Impact of Cross-Linked Hyaluronic Acid on Osteogenic Differentiation of SAOS-2 Cells in an Air-Lift Model Open
The aim of this study was to investigate the impact of cross-linked hyaluronic acid on osteoblast-like cells seeded on top of two collagen substrates, native porcine pericardium membrane (substrate A) and ribose cross-linked collagen membr…
Adjunctive Application of Hyaluronic Acid in Combination with a Sodium Hypochlorite Gel for Non-Surgical Treatment of Residual Pockets Reduces the Need for Periodontal Surgery—Retrospective Analysis of a Clinical Case Series Open
The comprehensive treatment of periodontitis stage 2 to 4 aims at the resolution of periodontal inflammation and “pocket closure”, which implies a residual probing depth of ≤4 mm and a negative BoP. However, supportive periodontal therapy …
View article: Microcirculation and Neutrophil-related cytokine concentrations are not altered around narrow diameter implants in T2DM patients during wound healing
Microcirculation and Neutrophil-related cytokine concentrations are not altered around narrow diameter implants in T2DM patients during wound healing Open
Objectives The aim of this study was to assess the microcirculation and the expression patterns of wound-healing related cytokines around narrow-diameter implants in type 2 diabetes mellitus (T2DM) and normo-glycemic patients. Materials an…
Implant stability of narrow diameter implants in hyperglycemic patients—A 3‐month case–control study Open
Objectives The aim of this prospective case–control study was to compare the development of implant stability quotients of narrow diameter implants in patients with type 2 diabetes mellitus (T2DM) and healthy individuals within the first 3…
Evidence‐based selection of reference genes for RT‐qPCR assays in periodontal research Open
Objective To underline the necessity of adequate reference genes for real‐time quantitative polymerase chain reaction (RT‐qPCR) and evaluate a novel tool for condition‐specific reference gene selection. Background RT‐qPCR is a commonly use…
Combined Sinus Grafting and Lateral Augmentation by a Hyaluronic Acid-Facilitated Guided Bone Regeneration Protocol – Case Series Supported by Human Histologic Analysis Open
Guided Bone Regeneration (GBR) is a well-established procedure for the regeneration of alveolar bone defects. In the case of highly complex defect situations, however, inconsistent treatment results are often achieved. Hyaluronic Acid (HA)…
Horizontal Augmentation of Chronic Mandibular Defects by the Guided Bone Regeneration Approach: A Randomized Study in Dogs Open
Various biomaterial combinations have been studied focusing on their ability to stabilize blood clots and maintain space under soft tissue to support new bone formation. A popular combination is Deproteinized Bovine Bone Mineral (DBBM) pla…
Gingival phenotype distribution in young Caucasian women and men – An investigative study Open
Objectives To evaluate the relationship between gingival phenotype and tooth location based on selected index teeth (“Ramfjord”) and assess possible differences between women and men. Material and Methods Thirty‐six women and 20 men volunt…
One-year performance of posterior narrow diameter implants in hyperglycemic and normo-glycemic patients—a pilot study Open
Objectives The aim of the study was to compare the performance of narrow diameter implants in patients with uncontrolled diabetes mellitus type 2 (T2DM) and normo-glycemic individuals during the first 12 months after implant loading. Mater…
An In Vitro Evaluation of Primary Stability Values for Two Differently Designed Implants to Suit Immediate Loading in Very Soft Bone Open
The achievement of sufficient implant stability in poor quality bone seems to be a challenge. Most manufacturers develop special dental implants, which are claimed to show higher stability even in very soft bone. The aim of this experiment…
Healing events observed in diabetic and NO‐diabetic patients after placement of narrow‐diameter implants in posterior edentulous maxilla or mandible – a case control study Open
Background: Type 2 Diabetes mellitus (T2DM) is a metabolic disorder, which is associated with impaired microvascular function and causes reduced tissue perfusion rates. Whereas the influence on general wound healing is evident, the role of…
Composite block sponge proved facilitating bone augmentation Open
Background: Guided Bone Regeneration (GBR) is considered sufficient in alveolar ridge deficiencies. Block type grafts and/or particulate materials combined with membrane for secluding space are the backbone of the principle. Block grafts b…
View article: Wound healing and PMN function at hydrophilic‐surface titanium‐zirconium implants in diabetic and healthy patients
Wound healing and PMN function at hydrophilic‐surface titanium‐zirconium implants in diabetic and healthy patients Open
Background: Diabetes mellitus II (DM II) patients exhibit impaired microcirculation and reduced neutrophil (PMN) function, causing higher susceptibility to periimplantitis and increased risk of wound infection. Shorter treatment regimens w…
View article: Comparison of a polyethylene glycol membrane and a collagen membrane for the treatment of bone dehiscence defects at bone level implants—A prospective, randomized, controlled, multicenter clinical trial
Comparison of a polyethylene glycol membrane and a collagen membrane for the treatment of bone dehiscence defects at bone level implants—A prospective, randomized, controlled, multicenter clinical trial Open
Objectives The aim of the present randomized, controlled clinical multicenter trial was to compare a polyethylene glycol (PEG) and a native collagen membrane (BG) for simultaneous guided bone regeneration at bony dehiscence‐type defects ar…
GTR Treatment in Furcation Grade II Periodontal Defects with the Recently Reintroduced Guidor PLA Matrix Barrier: A Case Series with Chronological Step‐by‐Step Illustrations Open
Molars with a furcation involvement (FI) exceeding grade 1 according to Hamp’s classification are at approximately doubled risk of tooth loss. Guided tissue regeneration (GTR) is a regenerative approach in the treatment of periodontal defe…