J.A. van Kan
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View article: Macrophage-like vascular smooth muscle cells dominate early atherosclerosis and are inhibited by targeting iron regulation
Macrophage-like vascular smooth muscle cells dominate early atherosclerosis and are inhibited by targeting iron regulation Open
Vascular smooth muscle cells (VSMCs) contribute dynamically to atherosclerosis at all stages but the molecular drivers of their phenotypic switching, especially during early plaque development, and how they contribute to plaque progression…
View article: From a vortex gas to a vortex crystal in instability-driven two-dimensional turbulence
From a vortex gas to a vortex crystal in instability-driven two-dimensional turbulence Open
We study structure formation in two-dimensional turbulence driven by an external force, interpolating between linear instability forcing and random stirring, subject to nonlinear damping. Using extensive direct numerical simulations, we un…
View article: Mobility of Bacterial Protein Hfq on dsDNA: Role of C-Terminus-Mediated Transient Binding
Mobility of Bacterial Protein Hfq on dsDNA: Role of C-Terminus-Mediated Transient Binding Open
The mobility of protein is fundamental in the machinery of life. Here, we have investigated the effect of DNA binding in conjunction with DNA segmental fluctuation (internal motion) of the bacterial Hfq master regulator devoid of its amylo…
View article: Investigating the Secondary Electron Emission of Nanomaterials Induced by a High‐Resolution Proton Beam
Investigating the Secondary Electron Emission of Nanomaterials Induced by a High‐Resolution Proton Beam Open
Herein, the secondary electron emission (SEE) from 1D nanomaterials in the form of nanorods is investigated. The small beam of a 1.5 MeV + H 2 hydrogen with a sub 70 nm in diameter allows studying the SEE with a very high resolution. A wid…
View article: Mobility of bacterial protein Hfq on dsDNA; Role of C-terminus mediated transient binding
Mobility of bacterial protein Hfq on dsDNA; Role of C-terminus mediated transient binding Open
The mobility of protein is fundamental in the machinery of life. Here, we have investigated the effect of DNA binding in conjunction with DNA internal motion of the bacterial Hfq master regulator devoid of its amyloid C-terminus domain. Hf…
View article: Intramolecular dynamics of dsDNA confined to a quasi-one-dimensional nanochannel
Intramolecular dynamics of dsDNA confined to a quasi-one-dimensional nanochannel Open
The intramolecular dynamics of double-stranded DNA confined to a long, straight, and rectangular channel with a cross-sectional diameter of 125 nm (two times the persistence length) is measured with fluorescence microscopy. The derived int…
View article: <strong>Fabrication of polymer nanofluidic lab on chip devices via PBW and NIL for DNA analysis and particle sorting</strong>
<strong>Fabrication of polymer nanofluidic lab on chip devices via PBW and NIL for DNA analysis and particle sorting</strong> Open
Jeroen A van Kan* Centre for Ion Beam Applications, Department of Physics, National University of Singapore, 117542, Singapore * Email: [email protected]; Tel.: +65-65166978 Proton Beam writing (PBW), a new 3D nanolithographic technique i…
View article: Compaction and condensation of DNA mediated by the C-terminal domain of Hfq
Compaction and condensation of DNA mediated by the C-terminal domain of Hfq Open
Hfq is a bacterial protein that is involved in several aspects of nucleic acids metabolism. It has been described as one of the nucleoid associated proteins shaping the bacterial chromosome, although it is better known to influence transla…
View article: Separation of superparamagnetic particles through ratcheted Brownian motion and periodically switching magnetic fields
Separation of superparamagnetic particles through ratcheted Brownian motion and periodically switching magnetic fields Open
Brownian ratchet based particle separation systems for application in lab on chip devices have drawn interest and are subject to ongoing theoretical and experimental investigations. We demonstrate a compact microfluidic particle separation…
View article: Effects of Hfq on the conformation and compaction of DNA
Effects of Hfq on the conformation and compaction of DNA Open
Hfq is a bacterial pleiotropic regulator that mediates several aspects of nucleic acids metabolism. The protein notably influences translation and turnover of cellular RNAs. Although most previous contributions concentrated on Hfq's intera…