Anton Razuvaev
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View article: Atheroma transcriptomics identifies ARNTL as a smooth muscle cell regulator and with clinical and genetic data improves risk stratification
Atheroma transcriptomics identifies ARNTL as a smooth muscle cell regulator and with clinical and genetic data improves risk stratification Open
BACKGROUND AND AIMS: The role of vascular smooth muscle cells (SMCs) in atherosclerosis has evolved to indicate causal genetic links with the disease. Single cell RNA sequencing (scRNAseq) studies have identified multiple cell populations …
View article: Atheroma transcriptomics identifies ARNTL as a smooth muscle cell regulator and with clinical and genetic data improves risk stratification
Atheroma transcriptomics identifies ARNTL as a smooth muscle cell regulator and with clinical and genetic data improves risk stratification Open
Background and Aims The role of vascular smooth muscle cells (SMCs) in atherosclerosis has evolved to indicate causal genetic links with the disease. Single cell RNA sequencing (scRNAseq) studies have identified multiple cell populations o…
View article: Transcriptomic and physiological analyses reveal temporal changes contributing to the delayed healing response to arterial injury in diabetic rats
Transcriptomic and physiological analyses reveal temporal changes contributing to the delayed healing response to arterial injury in diabetic rats Open
In this study, we have demonstrated that diabetic rats exhibit impaired arterial remodeling characterized by a delayed healing response. We show that increased contractile smooth muscle cell marker expression coincided with decreased matri…
View article: A single bilateral renal artery embolus traversing the aortic lumen – a hammock embolus
A single bilateral renal artery embolus traversing the aortic lumen – a hammock embolus Open
Renal artery embolization is rare and there is a lack of scientific studies on which to base clinical decisions. In this report, a case of bilateral renal artery embolism with a single embolus traversing the aortic lumen is presented for a…
View article: Plaque Evaluation by Ultrasound and Transcriptomics Reveals BCLAF1 as a Regulator of Smooth Muscle Cell Lipid Transdifferentiation in Atherosclerosis
Plaque Evaluation by Ultrasound and Transcriptomics Reveals BCLAF1 as a Regulator of Smooth Muscle Cell Lipid Transdifferentiation in Atherosclerosis Open
Background: Understanding the processes behind carotid plaque instability is necessary to develop methods for identification of patients and lesions with stroke risk. Here, we investigated molecular signatures in human plaques stratified b…
View article: Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation during Vascular Remodeling and Intimal Calcification
Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation during Vascular Remodeling and Intimal Calcification Open
Calcification is a prominent feature of late-stage atherosclerosis, but the mechanisms driving this process are unclear. Using a biobank of carotid endarterectomies, we recently showed that Proteoglycan 4 (PRG4) is a key molecular signatur…
View article: AMPA-Type Glutamate Receptors Associated With Vascular Smooth Muscle Cell Subpopulations in Atherosclerosis and Vascular Injury
AMPA-Type Glutamate Receptors Associated With Vascular Smooth Muscle Cell Subpopulations in Atherosclerosis and Vascular Injury Open
Objectives and Aims: Vascular smooth muscle cells (VSMCs) are key constituents of both normal arteries and atherosclerotic plaques. They have an ability to adapt to changes in the local environment by undergoing phenotypic modulation. An i…
View article: Lack of PCSK6 Increases Flow-Mediated Outward Arterial Remodeling in Mice
Lack of PCSK6 Increases Flow-Mediated Outward Arterial Remodeling in Mice Open
Proprotein convertases (PCSKs) process matrix metalloproteases and cytokines, but their function in the vasculature is largely unknown. Previously, we demonstrated upregulation of PCSK6 in atherosclerotic plaques from symptomatic patients,…
View article: PCSK6 Is a Key Protease in the Control of Smooth Muscle Cell Function in Vascular Remodeling
PCSK6 Is a Key Protease in the Control of Smooth Muscle Cell Function in Vascular Remodeling Open
Rationale: PCSKs (Proprotein convertase subtilisins/kexins) are a protease family with unknown functions in vasculature. Previously, we demonstrated PCSK6 upregulation in human atherosclerotic plaques associated with smooth muscle cells (S…
View article: Novel Multiomics Profiling of Human Carotid Atherosclerotic Plaques and Plasma Reveals Biliverdin Reductase B as a Marker of Intraplaque Hemorrhage
Novel Multiomics Profiling of Human Carotid Atherosclerotic Plaques and Plasma Reveals Biliverdin Reductase B as a Marker of Intraplaque Hemorrhage Open
Clinical tools to identify individuals with unstable atherosclerotic lesions are required to improve prevention of myocardial infarction and ischemic stroke. Here, a systems-based analysis of atherosclerotic plaques and plasma from patient…
View article: P562Expression profiling of complicated and uncomplicated atherosclerotic plaques of the lower extremities
P562Expression profiling of complicated and uncomplicated atherosclerotic plaques of the lower extremities Open
junctions, prior to stretching and enlargement of the endothelial cell, followed by alignment around a larger lumen.Conversely, loss of VE-cadherin and inhibition of actin prevented lumen remodelling.Conclusion: Arterial Flt1 by titrating …
View article: P575Regulation of purinergic signaling in response to arterial injury
P575Regulation of purinergic signaling in response to arterial injury Open
Introduction: Cell damage causes the release of a significant amount of ATP and subsequent activation of purinergic system.Purinergic signaling is involved in the regulation of a variety of physiological processes, including inflammation, …
View article: MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions
MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions Open
Rationale: In the search for markers and modulators of vascular disease, microRNAs (miRNAs) have emerged as potent therapeutic targets. Objective: To investigate miRNAs of clinical interest in patients with unstable carotid stenosis at ris…
View article: Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of <i>LMOD1, SYNPO2, PDLIM7, PLN</i> , and <i>SYNM</i>
Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of <i>LMOD1, SYNPO2, PDLIM7, PLN</i> , and <i>SYNM</i> Open
Objective— Key augmented processes in atherosclerosis have been identified, whereas less is known about downregulated pathways. Here, we applied a systems biology approach to examine suppressed molecular signatures, with the hypothesis tha…
View article: Gene expression signatures, pathways and networks in carotid atherosclerosis
Gene expression signatures, pathways and networks in carotid atherosclerosis Open
Background Embolism from unstable atheromas in the carotid bifurcation is a major cause of stroke. Here, we analysed gene expression in endarterectomies from patients with symptomatic (S) and asymptomatic ( AS ) carotid stenosis to identif…